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Tihomir Miralem

TitleResearch Assistant Prof (Part-Time)
InstitutionSchool of Medicine and Dentistry
DepartmentBiochemistry and Biophysics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester NY 14642
 
 Selected Publications
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  1. Nicholson TM, Uchtmann KS, Valdez CD, Theberge AB, Miralem T, Ricke WA. Renal capsule xenografting and subcutaneous pellet implantation for the evaluation of prostate carcinogenesis and benign prostatic hyperplasia. J Vis Exp. 2013; (78).
    View in: PubMed
  2. Miralem T, Lerner-Marmarosh N, Gibbs PE, Tudor C, Hagen FK, Maines MD. The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase Cd activity: the peptides are inhibitors or substrate for the protein kinase C. J Biol Chem. 2012 Jul 13; 287(29):24698-712.
    View in: PubMed
  3. Gibbs PE, Miralem T, Lerner-Marmarosh N, Tudor C, Maines MD. Formation of ternary complex of human biliverdin reductase-protein kinase Cd-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-?B, and inducible nitric-oxidase synthase (iNOS). J Biol Chem. 2012 Jan 6; 287(2):1066-79.
    View in: PubMed
  4. Gibbs PE, Miralem T, Maines MD. Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB. FASEB J. 2010 Sep; 24(9):3239-54.
    View in: PubMed
  5. Miralem T, Gibbs PE, Revert F, Saus J, Maines MD. Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression. J Biol Chem. 2010 Apr 23; 285(17):12551-8.
    View in: PubMed
  6. Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD. Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6870-5.
    View in: PubMed
  7. Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD. Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. FASEB J. 2007 Dec; 21(14):3949-62.
    View in: PubMed
  8. Maines MD, Miralem T, Lerner-Marmarosh N, Shen J, Gibbs PE. Human biliverdin reductase, a previously unknown activator of protein kinase C betaII. J Biol Chem. 2007 Mar 16; 282(11):8110-22.
    View in: PubMed
  9. Miralem T, Hu Z, Torno MD, Lelli KM, Maines MD. Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells. J Biol Chem. 2005 Apr 29; 280(17):17084-92.
    View in: PubMed
  10. Kravets A, Hu Z, Miralem T, Torno MD, Maines MD. Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1. J Biol Chem. 2004 May 7; 279(19):19916-23.
    View in: PubMed
  11. Miralem T, Avraham HK. Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus. Mol Cell Biol. 2003 Jan; 23(2):579-93.
    View in: PubMed
  12. Miralem T, Steinberg R, Price D, Avraham H. VEGF(165) requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells. Oncogene. 2001 Sep 6; 20(39):5511-24.
    View in: PubMed
  13. Price DJ, Miralem T, Jiang S, Steinberg R, Avraham H. Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells. Cell Growth Differ. 2001 Mar; 12(3):129-35.
    View in: PubMed
  14. Wang A, Miralem T, Templeton DM. Heparan sulfate chains with antimitogenic properties arise from mesangial cell-surface proteoglycans. Metabolism. 1999 Oct; 48(10):1220-9.
    View in: PubMed
  15. Miralem T, Templeton DM. Inactivation of kinase cascades in mesangial cells grown on collagen type I. Am J Physiol. 1998 Oct; 275(4 Pt 2):F585-94.
    View in: PubMed
  16. Templeton DM, Wang Z, Miralem T. Cadmium and calcium-dependent c-fos expression in mesangial cells. Toxicol Lett. 1998 Mar 16; 95(1):1-8.
    View in: PubMed
  17. Miralem T, Templeton DM. Heparin inhibits Ca2+/calmodulin-dependent kinase II activation and c-fos induction in mesangial cells. Biochem J. 1998 Mar 1; 330 ( Pt 2):651-7.
    View in: PubMed
  18. Whiteside C, Munk S, Zhou X, Miralem T, Templeton DM. Chelation of intracellular calcium prevents mesangial cell proliferative responsiveness. J Am Soc Nephrol. 1998 Jan; 9(1):14-25.
    View in: PubMed
  19. Miralem T, Wang A, Whiteside CI, Templeton DM. Heparin inhibits mitogen-activated protein kinase-dependent and -independent c-fos induction in mesangial cells. J Biol Chem. 1996 Jul 19; 271(29):17100-6.
    View in: PubMed
  20. Miralem T, Whiteside CI, Templeton DM. Collagen type I enhances endothelin-mediated contraction and induces nonproliferating phenotype in mesangial cells. Am J Physiol. 1996 Jun; 270(6 Pt 2):F960-70.
    View in: PubMed
  21. Van Ginkel MF, Heijink E, Dekker PB, Miralem T, van der Voet GB, de Wolff FA. Effect of aluminum chloride, -citrate, and -maltol on the calcium-mediated degradation of neurofilament proteins. Neurotoxicology. 1993; 14(1):13-8.
    View in: PubMed

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