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Xin Lin

TitleResearch Assistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 777
Rochester NY 14642
 
 Awards And Honors
2002 - 2003Excellent Graduate Student Award  | Lanzhou University, China
2003     Qiushi Award
2003     The 7th Fudan University Tan Jiazhen Prize Life Sciences Jiuyuan Award
2003     Science and Technology Award of Graduate Students  | Lanzhou University, China
2004     Zhong-He Award  | 8th Chinese International Peptide Symposium
2005     Postdoctoral Fellowship  | China Postdoctoral Science Foundation
2011     Best Postdoctoral Poster Award  | 3rd Annual Lung Research & Trainee Day, University of Rochester
2011 - 2013T32 Training Grant (HL66988)  | American National Institutes of Health (NIH)
2012     Travel Award  | Pittsburgh International Lung Conference, Pittsburgh, PA
2013     Abstract Scholarship Award  | ATS International Conference in Philadelphia, PA
 
 Overview
My research focuses on investigating gene therapy approaches and underlying mechanisms for protection and treatment for lung diseases emphasizing on acute lung injury/acute respiratory distress syndrome or pulmonary fibrosis.

Gene therapy is a promising approach to provide protection and treatment of acute and chronic lung diseases by restoring lung function. Our laboratory has developed a technique, electroporation, to efficiently deliver naked DNA to various tissues, including the living lung, with high-level gene expression and without damage. Our goal is to lead to a safe and effective approach to overexpress desired gene(s) in the injured lung to regulate lung function. It will provide evidence to move gene therapy toward clinical application.

 
 Selected Publications
List All   |   Timeline
  1. Roy S, Habashi N, Sadowitz B, Andrews P, Ge L, Wang G, Roy P, Ghosh A, Kuhn M, Satalin J, Gatto LA, Lin X, Dean DA, Vodovotz Y, Nieman G. Early airway pressure release ventilation prevents ards-a novel preventive approach to lung injury. Shock. 2013 Jan; 39(1):28-38.
    View in: PubMed
  2. Roy S, Sadowitz B, Andrews P, Gatto LA, Marx W, Ge L, Wang G, Lin X, Dean DA, Kuhn M, Ghosh A, Satalin J, Snyder K, Vodovotz Y, Nieman G, Habashi N. Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury. J Trauma Acute Care Surg. 2012 Aug; 73(2):391-400.
    View in: PubMed
  3. Lin X, Dean DA. Gene therapy for ALI/ARDS. Crit Care Clin. 2011 Jul; 27(3):705-18.
    View in: PubMed
  4. Lin X, Sime PJ, Xu H, Williams MA, LaRussa L, Georas SN, Guo J. Yin yang 1 is a novel regulator of pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1689-97.
    View in: PubMed
  5. Lin X, Wang YJ, Li Q, Hou YY, Hong MH, Cao YL, Chi ZQ, Liu JG. Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway. FEBS J. 2009 Apr; 276(7):2022-36.
    View in: PubMed
  6. Guo J, Lin X, Williams MA, Hamid Q, Georas SN. Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responses. J Allergy Clin Immunol. 2008 Jul; 122(1):195-201, 201.e1-5.
    View in: PubMed
  7. Feng Y, Lu Y, Lin X, Gao Y, Zhao Q, Li W, Wang R. Endomorphins and morphine limit anoxia-reoxygenation-induced brain mitochondrial dysfunction in the mouse. Life Sci. 2008 Mar 26; 82(13-14):752-63.
    View in: PubMed
  8. Lin X, Li Q, Wang YJ, Ju YW, Chi ZQ, Wang MW, Liu JG. Morphine inhibits doxorubicin-induced reactive oxygen species generation and nuclear factor kappaB transcriptional activation in neuroblastoma SH-SY5Y cells. Biochem J. 2007 Sep 1; 406(2):215-21.
    View in: PubMed
  9. Dong MJ, Lin XT, Zhao J, Guan YH, Zuo CT, Chen X, Dai JZ, Jiang BD. [Malignant tumor with false negative 18F-FDG PET image]. Zhonghua Zhong Liu Za Zhi. 2006 Sep; 28(9):713-7.
    View in: PubMed
  10. Lin X, Xue LY, Wang R, Zhao QY, Chen Q. Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation. FEBS J. 2006 Mar; 273(6):1275-84.
    View in: PubMed
  11. Zhao QY, Chen Q, Feng Y, Lin X, Wang R. [TIC4]endomorphins, analogues of endomorphins, have significantly enhanced vasorelaxant effects in rat aorta rings. Protein Pept Lett. 2005 May; 12(4):323-6.
    View in: PubMed
  12. Lin X, Chen Q, Xue LY, Ma XJ, Wang R. Endomorphins, endogenous opioid peptides, induce apoptosis in human leukemia HL-60 cells. Can J Physiol Pharmacol. 2004 Nov; 82(11):1018-25.
    View in: PubMed
  13. Lin X, Yang DJ, Cai WQ, Zhao QY, Gao YF, Chen Q, Wang R. Endomorphins, endogenous opioid peptides, provide antioxidant defense in the brain against free radical-induced damage. Biochim Biophys Acta. 2003 Nov 20; 1639(3):195-202.
    View in: PubMed
  14. Lin X, Cai YJ, Li ZX, Chen Q, Liu ZL, Wang R. Structure determination, apoptosis induction, and telomerase inhibition of CFP-2, a novel lichenin from Cladonia furcata. Biochim Biophys Acta. 2003 Jul 23; 1622(2):99-108.
    View in: PubMed
  15. Lin X, Cai YJ, Li ZX, Liu ZL, Yin SF, Zhao JC. Cladonia furcata polysaccharide induced apoptosis in human leukemia K562 cells. Acta Pharmacol Sin. 2001 Aug; 22(8):716-20.
    View in: PubMed

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