URMC Research Network - Jeffrey Purkerson

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Jeffrey Purkerson

Title	Research Assistant Professor
Institution	School of Medicine and Dentistry
Department	Pediatrics
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 777 Rochester NY 14642

Overview

Dr. Purkerson's research interests are:
1) Cell biology and physiology of the carbonic anhydrases
2) The response of renal epithelial cells to acid-base disturbances or injury.

Selected Publications

Purkerson JM, Tsuruoka S, Suter DZ, Nakamori A, Schwartz GJ. Adaptation to metabolic acidosis and its recovery are associated with changes in anion exchanger distribution and expression in the cortical collecting duct. Kidney Int. 2010 Nov; 78(10):993-1005.

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Peng H, Vijayakumar S, Schiene-Fischer C, Li H, Purkerson JM, Malesevic M, Liebscher J, Al-Awqati Q, Schwartz GJ. Secreted cyclophilin A, a peptidylprolyl cis-trans isomerase, mediates matrix assembly of hensin, a protein implicated in epithelial differentiation. J Biol Chem. 2009 Mar 6; 284(10):6465-75.

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Purkerson JM, Kittelberger AM, Schwartz GJ. Basolateral carbonic anhydrase IV in the proximal tubule is a glycosylphosphatidylinositol-anchored protein. Kidney Int. 2007 Mar; 71(5):407-16.

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Purkerson JM, Schwartz GJ. The role of carbonic anhydrases in renal physiology. Kidney Int. 2007 Jan; 71(2):103-15.

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Tsuruoka S, Watanabe S, Purkerson JM, Fujimura A, Schwartz GJ. Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosis. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F866-73.

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Purkerson JM, Smith RS, Pollock SJ, Phipps RP. The TRAF6, but not the TRAF2/3, binding domain of CD40 is required for cytokine production in human lung fibroblasts. Eur J Immunol. 2005 Oct; 35(10):2920-8.

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Purkerson JM, Schwartz GJ. Expression of membrane-associated carbonic anhydrase isoforms IV, IX, XII, and XIV in the rabbit: induction of CA IV and IX during maturation. Am J Physiol Regul Integr Comp Physiol. 2005 May; 288(5):R1256-63.

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Tsuruoka S, Schwartz GJ, Wakaumi M, Nishiki K, Yamamoto H, Purkerson JM, Fujimura A. Nitric oxide production modulates cyclosporin A-induced distal renal tubular acidosis in the rat. J Pharmacol Exp Ther. 2003 Jun; 305(3):840-5.

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Hwang Y, Nahm MH, Briles DE, Thomas D, Purkerson JM. Acquired, but not innate, immune responses to Streptococcus pneumoniae are compromised by neutralization of CD40L. Infect Immun. 2000 Feb; 68(2):511-7.

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Evans DE, Munks MW, Purkerson JM, Parker DC. Resting B lymphocytes as APC for naive T lymphocytes: dependence on CD40 ligand/CD40. J Immunol. 2000 Jan 15; 164(2):688-97.

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Purkerson JM, Parker DC. Differential coupling of membrane Ig and CD40 to the extracellularly regulated kinase signaling pathway. J Immunol. 1998 Mar 1; 160(5):2121-9.

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Weber JD, Isakson PC, Purkerson JM. IL-5 receptor expression and Ig secretion from murine B lymphocytes requires coordinated signaling by membrane Ig, IL-4, and IL-5. J Immunol. 1996 Nov 15; 157(10):4428-35.

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Purkerson JM, Isakson PC. Independent regulation of DNA recombination and immunoglobulin (Ig) secretion during isotype switching to IgG1 and IgE. J Exp Med. 1994 Jun 1; 179(6):1877-83.

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Purkerson J, Isakson P. A two-signal model for regulation of immunoglobulin isotype switching. FASEB J. 1992 Nov; 6(14):3245-52.

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Purkerson JM, Isakson PC. Interleukin 5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin (Ig) G1 and IgE. J Exp Med. 1992 Apr 1; 175(4):973-82.

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Catron KM, Purkerson JM, Isakson PC, Bender TP. Constitutive versus cell cycle regulation of c-myb mRNA expression correlates with developmental stages in murine B lymphoid tumors. J Immunol. 1992 Feb 1; 148(3):934-42.

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Isakson PC, Purkerson J, Catron K, Bender TP. A novel method for synchronizing a B cell lymphoma. J Immunol Methods. 1991 Dec 15; 145(1-2):137-42.

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Purkerson JM, Isakson PC. Isotype switching in anti-immunoglobulin-activated B lymphoblasts: differential requirements for interleukin 4 and other lymphokines to elicit membrane vs. secreted IgG1. Eur J Immunol. 1991 Mar; 21(3):707-14.

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Catron KM, Toth CR, Purkerson J, Isakson P, Bender TP. Constitutive and cell cycle regulated expression of c-myc mRNA is related to the state of differentiation in murine B-lymphoid tumors. Curr Top Microbiol Immunol. 1990; 166:197-202.

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Purkerson JM, Newberg M, Wise G, Lynch KR, Isakson PC. Interleukin 5 and interleukin 2 cooperate with interleukin 4 to induce IgG1 secretion from anti-Ig-treated B cells. J Exp Med. 1988 Sep 1; 168(3):1175-80.

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