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Gisela Beutner

TitleResearch Assistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 631
Rochester NY 14642
 
 Awards And Honors
1996     Travel Award  | European Bioenergetics Conference
2001     Young Investigator Award  | Bioenergetics of the Biophysical Society
 
 Overview
My primary research interest is energy generation in the heart, both physiologically and pathologically. Energy in form of ATP is made by mitochondria and necessary to keep the heart working and even apoptotic cell death requires energy. My special research interest is the mitochondrial permeability transition pore. Although a variety of mitochondrial proteins have been hypothesized to constitute the pore, the structural components are still not identified. It is well established that opening of the permeability transition pore will lead to apoptotic cell death. However, the physiological role of this pore is much less understood. My research will focus on the identification of the components of the permeability transition pore and how this pore is regulated during cardiac development. Experimental models of my research will include isolate mitochondria from the heart, primary cultured cardiac myocytes and in vivo models like transgenic mice.

 
 Selected Publications
List All   |   Timeline
  1. Sokolova N, Pan S, Provazza S, Beutner G, Vendelin M, Birkedal R, Sheu SS. ADP Protects Cardiac Mitochondria under Severe Oxidative Stress. PLoS One. 2013; 8(12):e83214.
    View in: PubMed
  2. Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS. Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts. J Biol Chem. 2011 Jun 17; 286(24):21324-9.
    View in: PubMed
  3. Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS. Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. FEBS Lett. 2010 May 17; 584(10):1948-55.
    View in: PubMed
  4. Kalifa L, Beutner G, Phadnis N, Sheu SS, Sia EA. Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity. DNA Repair (Amst). 2009 Oct 2; 8(10):1242-9.
    View in: PubMed
  5. Altschafl BA, Beutner G, Sharma VK, Sheu SS, Valdivia HH. The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile. Biochim Biophys Acta. 2007 Jul; 1768(7):1784-95.
    View in: PubMed
  6. Beutner G, Sharma VK, Lin L, Ryu SY, Dirksen RT, Sheu SS. Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling. Biochim Biophys Acta. 2005 Nov 10; 1717(1):1-10.
    View in: PubMed
  7. Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS. Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation. J Neurochem. 2002 Feb; 80(3):531-8.
    View in: PubMed
  8. Beutner G, Sharma VK, Giovannucci DR, Yule DI, Sheu SS. Identification of a ryanodine receptor in rat heart mitochondria. J Biol Chem. 2001 Jun 15; 276(24):21482-8.
    View in: PubMed
  9. Marzo I, Brenner C, Zamzami N, Susin SA, Beutner G, Brdiczka D, Rémy R, Xie ZH, Reed JC, Kroemer G. The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins. J Exp Med. 1998 Apr 20; 187(8):1261-71.
    View in: PubMed
  10. Beutner G, Rück A, Riede B, Brdiczka D. Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases. Biochim Biophys Acta. 1998 Jan 5; 1368(1):7-18.
    View in: PubMed
  11. Brdiczka D, Beutner G, Rück A, Dolder M, Wallimann T. The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition. Biofactors. 1998; 8(3-4):235-42.
    View in: PubMed
  12. O'Gorman E, Beutner G, Dolder M, Koretsky AP, Brdiczka D, Wallimann T. The role of creatine kinase in inhibition of mitochondrial permeability transition. FEBS Lett. 1997 Sep 8; 414(2):253-7.
    View in: PubMed
  13. Beutner G, Rück A, Riede B, Brdiczka D. Complexes between hexokinase, mitochondrial porin and adenylate translocator in brain: regulation of hexokinase, oxidative phosphorylation and permeability transition pore. Biochem Soc Trans. 1997 Feb; 25(1):151-7.
    View in: PubMed
  14. Beutner G, Ruck A, Riede B, Welte W, Brdiczka D. Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore. FEBS Lett. 1996 Nov 4; 396(2-3):189-95.
    View in: PubMed
  15. O'Gorman E, Beutner G, Wallimann T, Brdiczka D. Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain. Biochim Biophys Acta. 1996 Sep 12; 1276(2):161-70.
    View in: PubMed
  16. Beutner EH, Beutner GP. Classification of skin diseases by Noah Worcester. Int J Dermatol. 1991 Sep; 30(9):670-3.
    View in: PubMed

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