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RCBU News - 2009
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October 29, 2009
Dr. Diane Dalecki Elected Fellow of Acoustical Society of America
Diane Dalecki, Ph.D. (BME, RCBU) has been elected a Fellow of the Acoustical Society of America. She was recognized by the society for her
contributions to the bioeffects of sound and ultrasound.
Professor Dalecki's election to Fellow was acknowledged at an awards ceremony during the 158th Meeting of the Acoustical Society of America that was held in San Antonio, TX on October 26-30, 2009. -
October 1, 2009
New Collaboration between the Helguera (RIT), Dalecki, and Hocking Labs
A new collaboration, funded by the NIH, brings together the expertise of Professor Maria Helguera (Center for Imaging Sciences, RIT), Professor Diane Dalecki (BME, UR), and Professor Denise Hocking(Pharmacology & Physiology, UR). The collaborative effort focuses on developing novel, ultrasound tissue characterization techniques for engineered tissues. This work is part of a larger project, led by Drs. Dalecki and Hocking and funded by the NIH, that aims to develop ultrasound-based technologies for the field of tissue engineering.
Dr. Helguera's laboratory is devoted to advancing multimodal imaging and materials characterization techniques. Over the years, she has developed a suite of nondestructive, ultrasound-based materials characterization techniques for non-biological materials, such as polymers, ceramics, and layered materials. Through this new collaborative effort, the novel approaches that Dr. Helguera has developed and implemented for ultrasound characterization of non-biological materials will be translated to characterize the biological properties of engineered tissues. We propose to extend and apply high frequency ultrasound-based, tissue characterization techniques to monitor non-invasively biological and structural properties of cells and extracellular matrix proteins within three-dimensional engineered tissues. NIH support for the next two years will allow Dr. Helguera to spend the fall semesters and part of her summers devoted full-time to the research project as a Visiting Scientist in the Dalecki lab at the UR BME department. Drs. Helguera, Dalecki, and Hocking are all members of the Rochester Center for Biomedical Ultrasound.
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September 1, 2009
Michael Richards, Ph.D. Joins the RCBU Community as a Post-Doctoral Fellow in the Doyley Lab
Please welcome Michael Richards, Ph.D. to the RCBU community. Dr. Richards will begin his post-doctoral work in Dr. Marvin Doyley's lab in the Department of Electrical and Computer Engineering. Dr. Richard's research will focus on developing and testing an advanced intravascular ultrasound system for the diagnosis of atherosclerosis. He plans to use a novel type of imaging system that is inserted, like a catheter, into blood vessels to interrogate the mechanics of arterial plaques. Dr. Richards, an alumnus of the UR, received his B.S. in BME in 2001.
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July 15, 2009
Marvin Doyley Receives NIH Funding for IVUS Research
Marvin Doyley (ECE) has been awarded a new NIH R01 grant titled
IVUS Detection of Rupture Prone Plaques
. The overall goal of the project is to develop ultrasonic methods to assess the functional and structural properties of life-threatening atherosclerotic plaques and the arterial wall. Dr. Doyley will measure the functional properties of coronary arteries using a prototype intravascular ultrasound (IVUS) system, equipped with a dual frequency IVUS transducer (15 MHz and 30 MHz), to visualize molecules that are expressed preferentially by life-threatening atherosclerotic plaques. Ultrasound contrast agents will be used to target specific blood vessels. The outcome of the project will advance the use of ultrasound for the diagnosis of atherosclerosis. -
June 30, 2009
Carol Raeman - 20 Years with the RCBU!
This month the RCBU recognizes Carol Raeman's 20 years of employment at the University of Rochester! Carol is currently a Technical Associate I working in the laboratory of Professor Diane Dalecki in the Department of Biomedical Engineering. Carol started her employment with the University in 1989 working with Professor Ed Carstensen in the Department of Electrical Engineering. During her early years of employment, Carol played a key technical role in many studies on the biological effects of lithotripter fields. Only one year after her initial hire, Carol was already a co-author on 5 papers dealing with the bioeffects of lithotripter fields and pulsed ultrasound on the kidney, chick embryo, and lung. As her career progressed, Carol contributed to many significant studies on the effects of ultrasound on tissues containing contrast agents, the mechanisms for ultrasound-induced lung damage, effects of ultrasound on the heart and neural tissue, and the interaction of very low frequency underwater sound with biological tissues. Recent areas of Carol's work include applications of ultrasound in wound healing and cell and tissue engineering.
Carol is highly skilled in both our biological and acoustic techniques, and contributes to the design and completion of a wide variety of research projects in our lab. Her experience, ingenuity, technical ability, and collaborative skills make her an enormously valuable member of our laboratory team. She has made outstanding contributions to the field of biomedical ultrasound over the years and we are very fortunate that she is a member of our lab.
said Dr. Diane Dalecki. -
June 16, 2009
Carlos Sevilla Awarded NIH Pre-doctoral Fellowship
Carlos Sevilla was awarded a prestigious NIH Ruth L. Kirschstein National Research Service Award Individual Pre-doctoral Fellowship. This three-year award will provide funding for Carlos' thesis research project, titled
Promoting Chronic Wound Healing with Ultrasound and Fibronectin.
In his research, Carlos is investigating the ability of ultrasound to produce conformational changes in the extracellular matrix protein fibronectin that, in turn, stimulate cellular processes important for accelerating soft tissue wound repair. Carlos is a third year graduate student in the Department of Biomedical Engineering and his thesis research is co-advised by Dr. Denise Hocking and Dr. Diane Dalecki. Carlos is also a student member of the Rochester Center for Biomedical Ultrasound (RCBU). Carlos' research is part of a larger, multidisciplinary project, led by Drs. Dalecki and Hocking and funded by the NIH, that aims to develop the use of ultrasound for chronic wound therapy. -
June 16, 2009
Drs. Hocking and Dalecki receive NIH funding for summer students
Dr. Denise Hocking and Dr. Diane Dalecki have received funding from the NIH to support the summer research projects and career development of undergraduate and high school students for two years. The funding is in response to American Recovery and Reinvestment Act (ARRA) initiatives of the National Institute of Biomedical Imaging and Bioengineering (NIBIB). Research areas of student projects focus on studying the effects of ultrasound on cell growth and protein conformation, and novel applications of acoustic radiation force. This work will contribute to a larger, multidisciplinary project, led by Drs. Hocking and Dalecki and funded by the NIH, that aims to develop novel ultrasound technologies for the field of tissue engineering.
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June 5, 2009
Kelley Garvin Wins Best Student Paper Competition
Kelley Garvin won the Best Student Paper Competition at the 157th Meeting of the Acoustical Society of America held in Portland, OR from May 18-22. Her paper, titled
Ultrasound standing wave fields control the spatial distribution of cells and protein in three-dimensional engineered tissue,
was recognized as the best student paper in the Biomedical Ultrasound / Bioresponse to Vibration Technical Section. Kelley presented her recent work demonstrating the use of ultrasound fields to non-invasively control the spatial locations of cells in collagen-based engineered tissues. Ultrasound standing wave fields were used to organize cells into planar bands within collagen gels, resulting in a significant two-fold increase in cell-mediated gel contraction, suggesting that ultrasound-induced cell organization leads to a differential extracellular matrix remodeling. Further, using ultrasound to spatially band endothelial cells within collagen gels resulted in vessel sprouting. These novel technologies have important applications to the fabrication of engineered tissues with desired tissue characteristics. Kelley is a third year graduate student in the Department of Biomedical Engineering (BME) and her thesis research is co-advised by Dr. Diane Dalecki and Dr. Denise Hocking. Kelley is also a student member of the Rochester Center for Biomedical Ultrasound (RCBU). Kelley's research is part of a larger, multidisciplinary project, led by Drs. Dalecki and Hocking and funded by the NIH, that aims to develop novel ultrasound technologies for the field of tissue engineering. -
May 18, 2009
RCBU Members Attend Acoustical Society of America Meeting
The RCBU was well represented at the Meeting of the Acoustical Society of America held in Portland, Oregon on May 18-22, 2009, with the following presentations: Ultrasound Standing Wave Fields Control the Spatial Distribution of Cells and Protein in Three-Dimensional Engineered Tissue by Kelley A. Garvin, Denise Hocking, and Diane Dalecki. Kelley Garvin won the Best Student Paper Competition in the Biomedical Ultrasound/Bioresponse to Vibration Technical Section with this paper. Lung Hemorrhage Produced by Exposure to Underwater Acoustic Impulses by Diane Dalecki, Sally Z. Child, and Carol H. Raeman. Comparison of Unconfined Compression and Spatially Modulated Ultrasound Radiation Force Estimates of Shear Modulus by Stephen McAleavey, Erin Collins, Johanna Kelly, Etana Elegbe, and Manoj Menon.
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May 15, 2009
Rochester's Engineering School Named for Edmund A. Hajim
the University announced that its engineering school will, effective July 1, be officially named the Edmund A. Hajim School of Engineering and Applied Sciences.
The naming recognizes alumnus Edmund Hajim's many decades of service and contributions to the University, including his $30 million gift commitment last fall to the School of Engineering and Applied Sciences. Hajim earned his bachelor's degree in chemical engineering at Rochester in 1958, has had a highly successful career as a senior executive for several Wall Street firms, has served for the past year as the Chairman of the University's Board of Trustees, and has been a member of the Board since 1988.
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May 13, 2009
Senior Design Students Take on Ultrasound Problem for Final Project
For the last nine years, senior engineering students have helped real-life customers solve biomedical engineering problems through a two-semester Senior Design course taught by Amy Lerner, Ph.D., and Scott Seidman, Ph.D. This year, BME seniors Aaron Gelinne, Bo Wang, Andrew Bochenko, and Tony Broyld solved Dr. Paul Bigeleisen's need for a system to stabilize an ultrasound imaging transducer when inserting a needle into tissue. According to Dr. Lerner,
The UltraNeedle team was a great example of the kind of successful design process our students use to develop medical innovations. The students worked extensively with their clinical 'customer', learning about the technical challenges of the medical setting, and the demands of the end-user. They developed a simple, but elegant prototype that allowed for significant testing by representative customers. At the same time, they thoroughly considered the challenges that may be faced in manufacturing, marketing and obtaining regulatory approval for their device. We are very proud of their success, and look forward to continued development of their proposed solution.
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