Email this pageCore Facilities
The Core Facilities provide services to all researchers at the University of Rochester School of Medicine and Dentistry. An Executive Oversight Committee provides the Senior Associate Dean of Basic Research, Stephen Dewhurst, Ph.D. with recommendations for overall core facility strategic planning and management.
Contact: Sally Quataert, Ph.D., URSMD Core Facilities Director, 273-2454, Sally_Quataert@urmc.rochester.edu
Biomolecular Interaction Core Facility
The Biomolecular Interaction core facility seeks to give access to custom affinity reagents to researchers in the University. We utilize phage display to generate recombinant antibodies to user provided target molecules and produce the single-chain Fv proteins for the user. We also can perform affinity measurements using surface plasmon resonance or provide access to trained users to this equipment.
Contact: Mark Sullivan, Ph.D., 273-1629, Mark_Sullivan@urmc.rochester.edu
Biosafety Level 3 (BSL-3) Core
The Biosafety Level 3 facility (BSL-3) is available for the use of any researcher at the university whose work requires manipulation of biological agentswhich may cause serious or potentially lethal disease as a result of exposure by the inhalation route.
Contact: Marty Pavelka, Ph.D., 275-4670, Martin_Pavelka@urmc.rochester.edu
Electron Microscope Research Core
The principal mission of this Electron Microscope Research Core (EM Core) is to provide University of Rochester researchers support in high magnification image analysis of cells and tissue in the fields of Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and combined Scanning/Transmission EM (STEM).
Contact: Karen Bentley, M.S, 275-1954, Karen_Bentley@urmc.rochester.edu
Flow Cytometry and Immunologic Analysis
Flow cytometry resources are now available in several locations within the medical center.
The mission of URMC Flow Cytometry Core is to provide investigators with state-of-the-art
instrumentation along with the human expertise to support all that is possible now, while
pushing the limits of what can be done with flow cytometry.
The Core currently has analytical tools including a FACSCanto (8-colors) and 3 LSR-II's
(two 11-color and an 18-color instrument) from BD Biosciences. We also have a BD 13-color
FACSAria cell sorter, and our recent acquisition, an Amnis ImageStream Imaging Cytometer.
Instrumentation is only part of what we offer. In close association with the Human
Immunology Center , we also offer comprehensive training for your staff, consultation for
maximizing the effectiveness and cost of your experiments, as well as an environment that
fosters success in both existing methods and crossing the boundaries into new frontiers.
Contact: Peter Keng, Ph.D., 275-6332, Peter_Keng@urmc.rochester.edu,
Tim Bushnell, Ph.D., 273-5535, Tim_Bushnell@urmc.rochester.edu
Functional Genomics Center
The Funcational Genomics Center consolidates the Microarray Core, & the Nucleic Acid Core Facilites into one entity. The center provides DNA sequencing; DNA and RNA extraction, purification, and measurement; microarray services, quantitative RT-PCR, genotyping, DNA fragment analysis; SNP analysis; assistance with interpretation of results.
Contact: Stephen L. Welle, Ph.D., 273-3117, Stephen_Welle@urmc.rochester.edu
Gene Targeting and Transgenic Core
At this time, the Gene Targeting and Transgenic core provides expertise and assistance in the production of transgenic mouse models by either DNA microinjection or gene targeting in embryonic stem (ES) cells.
Contact: Lin Gan, Ph.D., 273-1510, Lin_Gan@urmc.rochester.edu
High Throughput Screening (HTS) Core
The University of Rochester High Throughput Screening (HTS) Core provides investigators with relatively low cost access to screening chemical libraries for identification of novel molecules that can be used to perturb biological systems. We offer the capacity to develop assays for high throughput screening, the ability to screen relatively small libraries to obtain preliminary data for grant proposals as well as to screen much larger libraries for identification of leads for therapeutics.
Contact: Alan V. Smrcka, Alan_Smrcka@urmc.rochester.edu,
Ben Miller, Benjamin_Miller@urmc.rochester.edu
Human Immunology Center Laboratory
The Human Immunology Center (HIC) and its core laboratory were established to acquire, refine and develop expertise in cutting-edge techniques and to support applications in Human Immunology research. The HIC serves to enhance multi-disciplinary research initiatives catalyzing key clinical and basic immunology research in vaccines, HIV/AIDS, autoimmunity, allergy/asthma, transplantation as well as cancer immunology. The Center's core lab provides assistance and expertise in immunological method development, standardization and validation through individual and group training programs.
Molecular Imaging Facility
The Molecular Imaging Facility provides researchers at the University of Rochester with access to state of the art instruments capable of detecting and quantifying the levels and positions of radio- and fluorescently labeled molecules in a variety of formats including gels, blots and microtiter plates.
Contact: Scott Butler, Ph.D., 275-7921, btlr@mail.rochester.edu
Multi-Photon Core Facility
The Multi-Photon Core Facility is available to all investigators at the University of
Rochester to acquire and analyze high-quality images using cutting-edge multi-photon technology. The facility is equipped with a brand new Mai Tai HP Deep Sea Laser from Spectra Physics and an Olympus Fluoview 1000 AOM-MPM Microscope. The Multi-photon Core is expected to be operational in July 2008.
Contact: Karl Kasischke, M.D., 273-2870, Karl_Kasischke@urmc.rochester.edu
Pathology/Morphology Imaging Facility
The Pathology/Morphology Imaging core facility provides a Leica Confocal Microscope, an Olympus Flourescent Microscope, and an Arcturus PixCell Laser Capture Microscope for use by University of Rochester faculty. All users are provided the ability and expertise to characterize biologic specimens using sophisticated fluorescent and/or brightfield microscopy.
Contact: Linda Callahan, PhD, 275-1317, Linda_Callahan@urmc.rochester.edu; for assistance with experimental design and data interpretation.
Contact: David Pasternack, M.S, 273-4097, David_Pasternack@urmc.rochester.edu for an appointment to learn the equipment. Schedule sign-up online.
Proteomics Center
The University of Rochester Proteomics Center provides protein characterization support, predominantly in the form of proteomic technology. The analytical strengths of the core are mass spectrometry and separation sciences. In a classical proteomic application, a complex sample matrix, such as serum, is separated into individual protein fractions, the identities of which are then determined with mass spectrometry. The core processes a myriad of sample types, from complex clinical matrices to simple purified proteins, for identification of unknowns or verification of identity.
Contact: Alan Friedman Ph.D., 276-0769, Alan_Friedman@urmc.rochester.edu
RCBI (Rochester Center for Brain Imaging)
The Rochester Center for Brain Imaging (RCBI) provides researchers at the University of Rochester, as well as neighboring institutions, with access to a state-of-the-art 3T magnet for research using magnetic resonance imaging (MRI).
Contact: Richard N. Aslin, 275-8687, aslin@cvs.rochester.edu
Vivarium
The Vivarium is a centralized resource facility with staff and programs that support the research and educational uses of laboratory animals.
Contact: Jeff Wyatt, DVM., 275-2651, Jeff_Wyatt@urmc.rochester.edu
Xenogen IVIS In Vivo Imaging Core
The mission of the in vivo bioluminescence imaging core is to allow the detection of bioluminescent tracer molecules in living small animals.
Contact: Nick Crispe, M.D., Ph.D., 273-5647, Nick_Crispe@urmc.rochester.edu
Cold Storage Core (CSC)
The CSC provides a discreet area where investigators can keep freezers for long term storage of research materials. The entire facility is alarmed and power protected.
Contact: Richard Reichman, 275-5871, Richard_Reichman@urmc.rochester.edu
Business Opportunities
Facilitating the transfer of URMC science and technology from the laboratory to the realm of medical advancement.