Data Management, Informatics and Computational Biology Capabilities
Hulin Wu Ph.D., Director
Hulin_Wu@URMC.Rochester.edu
- Develop and implement the data management system (RPRC-BLIS) for collection, storage and data integration of clinical, specimen inventory and laboratory data and files.
- Develop study data management monitoring plans which includes the implementation of study-specific reports to monitor, enrollment, data completeness and quality, laboratory data workflows and timelines.
- Consult with investigators to provide statistical support in study/experimental design of research projects
- Includes: advises on appropriate experimental design, sample size for clinical studies and laboratory experiments, inclusion/exclusion criteria, definition of exposure and outcome variables, determination of randomization/stratification schemes and review of data collection forms.
- Perform data monitoring in accordance with the approved Data and Safety Monitoring Plan and interim statistical analysis, if appropriate.
- Prepare data analysis plan and perform analysis of completed studies, including statistical analysis, report writing and development of graphical displays for publication and presentations.
- Consult with investigators to provide informatics support for high-throughput transcription, metabolomics and flow cytometry data analysis. May include:
- High-throughput data processing including data normalization
- High-throughput data analysis and integration (including integration with other external bioinformatics databases)
- Bioinformatics data annotation and interpretation
- Utilization of high-performance HPC resources in collaboration with CIRC staff.
- Apply systems biology approach to integrated exploratory data analysis of high-dimensional, complex data.
- Work with investigators to develop novel analysis methods and tools for data processing and/or analysis.
- Create plan for provision/release of de-identified RPRC Data to DMID-designated public data repositories.
- Work with University’s Office of Research and Program Administration, University IT, and Academic IT to meet FISMA requirements for RPRC-BLIS data management system.
- Participate as protocol team members and attend protocol-specific meetings.
- Provide reporting per contract and project requirements.
