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Diagnostic Neuroradiology Procedures

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Brain (Carotid)
Angiogram
Functional MRI Myelogram and CT Myelogram
Cervical Spine Biopsy Intraoperative Angiography Sacral Biopsy 
Cisternogram MR Angiogram Sialogram 
CT Angiogram MR Diffusion   Skull Biopsy
CT Guided Biopsy MR Imaging Spinal Angiogram
CT MR Imaging of the Fetus Spine Biopsy
Dacrocystogram MR Perfusion  TMJ Imaging
Dentascan MR Spectroscopy  3D Reconstruction
Discogram MR Safety  
  

Carotid/Cerebral
(Brain) Angiogram

A Carotid or Cerebral Angiogram is a diagnostic test designed to show the condition of the blood vessels of the brain. X-ray contrast material is injected into an artery through a small tube  (catheter), and X-ray images are obtained. 
   Carotid angiography is used to study the caliber of the carotid artery and look for stenosis that may be significant and cause an increased risk of stroke. Carotid angiography is performed with a routine angiographic procedure from the groin using thin catheters. Often both the carotid artery in the neck and the intracerebral vessels are studied at the same time.

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   For information regarding outpatient angiograms see http://www.urmc.rochester.edu/smd/Rad/ptangio.htm.

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Cervical Spine Biopsy

Cervical spine biopsies can be performed with CT fluoroscopy.  This is indicated for lesions of the cervical spine that are thought to be metastatic and if so, would change the management of the patient.  With attention to details, the carotid artery, the esophagus and other vital structures in the neck can be avoided and good sample material can be obtained from the vertebral bodies with a low complication rate.

Biopsy of the cervical spine can be safely done with CT guidance. Image to the right is a case of hemangioma with an extra osseous component. The standard 13G bone biopsy needle is used.

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Cisternogram

neuroimages/cisterno2.jpg Cisternograms are used to diagnosis CSF (cerebrospinal fluid) leakage. A CSF leak can occur after trauma and it is often difficult to tell exactly where the location of the leakage is. In order to determine the position of the leak a contrast material is injected into the subarachnoid space via a lumbar approach. The patient is then tilted with the head down and a CT scan is performed to see where the CSF and the contrast is leaking out. A cisternogram can also be performed with a nuclear medicine technique. This is slightly more sensitive but the anatomic resolution is lower than the CT cisternogram.
Often the two examinations are combined so that both the CT and nuclear contrast materials are injected at the same time. This offers the best anatomic resolution with the highest sensitivity.

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CT Angiogram
Computed Tomography Angiography (CTA)

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CTA 3D rotational angio (Flash movie full screen view)
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CT (computed tomography) angiography (CTA) is an examination that uses x-rays to visualize blood flow in arterial vessels throughout the body, from arteries serving the brain to those bringing blood to the lungs, kidneys, and the arms and legs. CT combines the use of x-rays with computerized analysis of the images. Beams of x-rays are passed from a rotating device through the area of interest in the patient's body from several different angles so as to create cross-sectional images, which then are assembled by computer into a three-dimensional picture of the area being studied. Compared to catheter angiography, which involves injecting contrast material into an artery, CTA is much less invasive and a more patient-friendly procedure; contrast material is injected into a vein rather than an artery. This exam has been used to screen large numbers of individuals for arterial disease. Most patients have CT angiography without being admitted to hospital. 
 
   For further information see http://www.radiologyinfo.org/content/ct-angiography.htm.

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Computed Tomography (CT) Guided Biopsy

   CT (computed tomography) guided biopsies are done percutaneously when lesions are not palpable and cannot be done in the clinical setting. CT guided biopsies offer a noninvasive alternative to open surgical biopsies.

The image to the right shows a needle placed inferior to the foramen ovale. The second case below shows an orbital lesion that was biopsied with a fine needle technique.

Also see http://www.urmc.rochester.edu/smd/Rad/
neurocases/Neurocase07.htm
.

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Computed Tomography (CT)

   CT (computed tomography), sometimes called CAT scan, uses special x-ray equipment to obtain many images from different angles, and then join them together to show a cross-section of body tissues and organs. CT scanning provides more detailed information on head injuries, brain tumors, and other brain diseases than do regular radiographs (plain films). It also can show bone, soft tissues, and blood vessels in the same images. CT of the head and brain is a patient-friendly exam that involves little radiation exposure.
    For further information see http://www.radiologyinfo.org/content/ct_of_the_head.htm
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This is an axial thin section Head CT image that depicts the brain parenchyma and the fused spaces in the head (ventricular and subarachnoid space). CT scans are helpful in detecting abnormalities of the brain. Face (Sinus) CT is typically done to look for fractures or sinus disease.
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Neck CT can be performed for a multitude of reasons. It can be done to look for lymph nodes associated with cancer, for traumatic injuries, and for inflammatory conditions such as an abscess spreading from the face down towards the neck Orbit CT scanning is performed to evaluate for disease in the orbits such as trauma or tumors. In this patient there is proptosis on the right side.
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Lumbar Spine CT Thoracic Spine CT can be done for question of other bone conditions evaluated with CT scans.
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Cervical Spine CT
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Three-dimensional (3D) Face CT

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Dacrocystogram

This is a special radiographic test to see if there is blockage of the tear canals. Radiographic dye is injected into the tear canal and then radiographic pictures are taken to determine if the duct is blocked or if there is free flow of tears from the eye into the nose. It is a simple procedure which causes no pain and no risk of damage to the eyes or tear ducts. A few drops of a local anesthetic are instilled into the eye. A thin probe is placed into the opening of tear duct in the medial portion of the lower eye lid. A small amount of fluid is injected through the tear duct and X-ray images are taken. During injection the fluid may cause some trickling in the back of the mouth and there may be a bitter taste in the mouth. The test does not affect eye sight and the patient may drive immediately after the test is performed. /neuroimages/dacrocyst.jpg

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Dentascan

   Dentascan is a specialized CT scan of the mandible or maxilla often done before placement of dental implant. Dentascan helps the dental surgeon to evaluate the dimensions of the jaw bone and assess the quality of the jaw bone for optimal results of placement of dental implant.
   Dentascan can also be used to study dental pathology when dental x-rays and panoramic x-rays do not provide the needed information.
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Discogram

(download Discogram Patient Brochure in Acrobat PDF format)

See http://www.spineuniverse.com/displayarticle.php/article646.html and http://www.neurosurgery.org/focus/aug02/13-2-13.pdf

   Discogram is a diagnostic test primarily performed to identify the source of pain. It also gives information about the condition of the discs. The patient is initially given intravenous medication for relaxation and pain, and after local anesthesia a needle is placed into the suspected disc and a small amount of radiographic dye is injected. A normal disc will not be painful when a small amount of dye is injected. However if the patient's pain is coming from the disc, it is likely that the contrast injection will cause pain similar to what the patient normally experiences.
   Discography is usually performed in the lumbar spine but can be done also in the cervical and thoracic spine.

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Cervical discogram
  When the pain is located in the neck and other studies have not been able to identify the source of the pain cervical discogram can sometimes be helpful. Thin needles are place in the disks and if injection pressure causes significant pain this is an indication that the pain is originating from the disk itself. Three or more disks are often injected to make sure that the painful one is included in the study.
/neuroimages/cdiskoAP.jpg /neuroimages/cdiskolat.jpg
Lumbar discogram

    When the pain is thought to be discogenic and is located in the lumbar spine a discogram of this region is often helpful to pinpoint the origin of the pain. Here is a L3/4 through L5/S1 disogram. The single level discogram illustrates the normal morphology of the lumbar disk
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Functional MR Imaging

Functional MR imaging of the brain is a specialized MR study where the radio waves in a strong magnetic field are used to measure the quite and tiny metabolic changes that take place in an active part of the brain. Physicians know the general area of the brain where speech, sensation, memory and other functions occur. However the exact location varies from individual to individual. Injuries and diseases, such as stroke or brain tumor, can even cause function to shift to other parts of the brain. Functional MR imaging cannot only help the radiologist to look closely at the anatomy of the brain but can help them to determine precisely which part of the brain is handling critical functions such as thought, speech, motor activity, and sensation. This information can be critical when planning surgery or radiation therapy.
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    For more information see http://www.radiologyinfo.org/content/functional_mr.htm#Description

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Intraoperative Angiography

Intraoperative angiography is done in the operating room during a surgical procedure of the brain. One common situation is when a brain aneurysm is clipped. The intraoperative angiogram is done to make sure that the aneurysm clip is correctly placed. If there is still a residual aneurysm the clip can be adjusted or another clip can be placed. In the situation where an adjacent vessel has been compromised the clip this can also be adjusted.

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MR Angiogram
Magnetic Resonance Angiography (MRA)

    Magnetic resonance imaging (MRI) is a method of producing extremely detailed pictures of body tissues and organs without the need for x-rays. The electromagnetic energy that is released when exposing a patient to radio waves in a strong magnetic field is measured and analyzed by a computer, which forms two- or three-dimensional images that may be viewed on a TV monitor. MR angiography (MRA) is an MRI study of the blood vessels. It utilizes MR technology to detect, diagnose and aid the treatment of heart disorders, stroke and blood vessel diseases. MRA provides detailed images of blood vessels without using any contrast material, although today a special form of contrast usually is given to make the MR images even clearer. The procedure is painless, and the magnetic field is not known to cause tissue damage of any kind.
    For further information see http://www.radiologyinfo.org/content/mr-angiography.htm
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Head MR Angiography is usually done without contrast. The technique is completely noninvasive and provides a good visual aid. Neck MRA in this case has been performed with contrast. It covers from the aortic arch to the Circle of Willis.

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MR Diffusion

See http://www.diagnosticimaging.com/advancedMR/diffusion.shtml

   MR diffusion-weighted images (DWI) detect changes in the mobility of free molecular protons. In all biological systems, the free diffusion of proton is limited by physical barriers such as cell membranes or chemical interactions such as bonding to micromolecules. Comparison of this limited diffusion with the diffusion characteristics of free water can provide information on the physical and physiologic conditions of tissue.
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Brain MR Diffusion Images

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MR Imaging
Magnetic Resonance Imaging

    MRI (magnetic resonance imaging) uses radio waves and a strong magnetic field rather than x-rays to provide remarkably clear and detailed pictures of internal organs and tissues. This technique has proved very helpful to radiologists in diagnosing tumors of the brain as well as disorders of the eyes and the inner ear. It requires specialized equipment and expertise and allows evaluation of some body structures that may not be as visible with other imaging methods.
    For further information see http://www.radiologyinfo.org/content/mr_of_the_head.htm
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Head MR

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MR Imaging of the Face and Orbits is done for inflammatory neoplastic lesions. Contrast is often given to help improve the image quality and increase the diagnostic yield. Neck MR
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TMJ MR Lumbar Spine MR

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MR Imaging of the Fetus

   MR imaging is occasionally done of the fetus. Usually it is to look for congenial abnormalities of the brain and often to clarify something seen on ultrasound. Below are examples of fetal MR images.

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   MR imaging complements ultrasound when additional information is needed to make treatment decisions during pregnancy. Up till recently studies were limited by fetal motion but now the scanners are so fast that it is possible to get good images even if the fetus moves. Due to fast imaging techniques now available, images can be obtained in less than 1/2 a second. This means that neither the mother nor the fetus needs to be sedated. MR imaging has proven to be especially beneficial in evaluation of fetal brain abnormalities such as:

  • Encephalocele see AJR 1999;172:813-818
  • Agenesis of the corpus callosum
  • Porencephaly - destruction of brain tissue
  • Partial absence of the septi pellucidi

There is no known risk involving fetal MRI.

For more information see:
http://radiology.bidmc.harvard.edu/research/ultrasound/us_fetalmr/fetalMR.html and http://www.parksidemri.com/physician/casestudy/w99


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MR Perfusion

See http://www.isi.uu.nl/Research/Projects/project.php?P=102

MR perfusion is a specialized MR technique that evaluates the relative perfusion tissue. Most of the time this is done in association with contrast enhancement but future techniques are promising for the possibility of being able to do it without contrast enhancement. MR perfusion is often done in situations of tumors of the brain as well as ischemic injuries (stroke).

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MR Spectroscopy

MR spectroscopy is a specialized way to analyze the chemical contents of the brain tissue. It is used to characterize the brain tumors, infarcts or stroke, metabolic disorders, developmental disorders as well as infectious processes. Although MR spectroscopy is relatively new, it can be very valuable in adding information to the MR image sequences obtained. For more information see http://www.mritutor.org/mritutor/mrs.htm, http://www.mghneuroradiology.org/NewFiles/mrs.html,

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MR Safety

MR Safety – ACR 2004 White Paper

Drug Delivery Patch
     If the metallic foil of the patch is in the volume of excitation, the case should be discussed with the radiologist.
     An icepack can be placed directly on the patch since the problem is heat.
If the patch is removed a specific staff member should be given responsibility for insuring that it is replaced or repositioned.
Accompanying Family/Personnel
     Persons who accompany a patient going into the MR scanner should be screened in the same way as a patient.
Fetal MR Contrast Agent
     Contrast should be given only when there is overwhelming potential benefit to the patient and/or fetus outweighing theoretical but potential real risk of long term exposure to the developing fetus. MR contrast passes through the placental barrier and enters the fetal circulation. The MR contrast is filtered in the fetal kidneys and excreted into the amniotic fluid and may remain in the amniotic fluid for an indeterminate amount of time until it is reabsorbed and eliminated. The impact on the fetus from the free gadolinium ions in the amniotic fluid is unclear.
Cardiac Pacemakers and Defibrillators
     Pacemakers and defibrillators are contra-indications for routine MR imaging.

Links:
http://www.ajronline.org/cgi/reprint/182/5/1111

http://www.ajronline.org/cgi/content/full/182/5/1111?maxtoshow=&HITS=
10&hits=10&RESULTFORMAT=1&andorexacttitle= and&andorexacttitleabs=
and&andorexactfulltext=and&searchid=1083335498444_3376&stored_search=
& FIRSTINDEX=0&sortspec=relevance&volume=182&


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Myelogram and CT Myelogram
(download Myelogram Patient Brochure in Acrobat PDF format)

General Information

A myelogram is an x-ray examination of the spinal canal and its nerves. The purpose of the procedure is to detect whether there is a compression of the spinal cord or the nerves coming out of the spinal cord.
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In order to see these nerves an x-ray contrast dye must be injected into the spinal canal. In this procedure the skin of the lower back is cleansed and a local anesthetic is administered. Then the radiologist or the physicians’ assistant inserts a needle to inject radiographic contrast and, with the aid of a TV monitor, x-ray images are obtained that show the nerve roots. The person performing the study may tilt the table somewhat to move the contrast along the spinal canal. You will be instructed which position to assume and when to avoid breathing while the radiographs are obtained. /neuroimages/MyeloL.jpg

Patient Preparation

The night before and on the morning of the procedure, the patient should drink plenty of fluids especially caffeinated products. The patient may have a light meal up to two hours prior to the procedure. The patient must arrange to be driven directly home by another individual after the myelogram. There should be no eating or drinking for two hours immediately before the study.

Immediately prior to the myelogram the patient is given oral medication for relaxation and pain control.

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Lumbar CT Myelogram
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Lumbar CT Myelogram - Sagittal view Lumbar CT Myelogram - Axial view
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Cervical CT Myelogram Thoracic CT Myelogram - Sagittal view

Side Effects

The most common side effect is a spinal headache. This is a relatively uncommon occurrence today with the use of very thin needles. If it happens it may last from a few hours to several days and can be treated with over the counter pain medication in most instances. Less commonly, such headaches are associated with nausea and vomiting. Persistent nausea and vomiting may cause dehydration and should be reported promptly to your primary care physician.
   If you develop a severe headache that over the counter medication does not help or you still have a headache on the second morning following your myelogram, please call the radiologist at 585-275-2222. Identify yourself as a post-myelogram patient and ask to be directed to the neuroradiologist on call.

Frequently asked questions regarding a myelogram

Q. What is a Myelogram?
A.

A Myelogram is an x-ray study of the spine, that uses dye directly injected into your spinal canal to show where your spinal cord or nerves may be damaged by bone or disc in your spine. It is often used, in addition to an MRI study, to clearly define the structure of the nerves.

Q. What must be done before the Myelogram?
A.

The night before and morning of the study, you must drink plenty of fluids. You may have a light meal up to two hours prior to the study, but must not eat or drink for the two hours just prior to the procedure.You must arrange for a responsible adult to drive you home and stay with you the night following the procedure.
You must arrange to bring any prior MRI studies with you for the procedure.
You cannot return to work after this procedure, and must not engage in any strenuous activities for 72 hours.

Q. Can I take my usual medications before the study?
A.

Yes, with a few exceptions:
   COUMADIN/WARFARIN must be stopped at least three days prior to the study, with permission from the physician who ordered its use. The myelogram will not be performed if it is not stopped as directed.
LOVENOX must be stopped 24 hours prior to the procedure. COMPAZINE, and other PHENOTHIAZINES must be stopped two days prior to the myelogram. Ask your doctor if you have questions about if any of your medicines must be stopped.
   Take all of your other medications as usual, the morning of the procedure, with a small amount of water. PLEASE take your pain medication as usual!
   Consult your doctor about resuming any medications that had been stopped for the myelogram.

Q. What if I have a contrast allergy?
A.

ANY contrast allergy, even if not severe, MUST be pre-treated with PREDNISONE 50mg tablet at 25 hours, 13 hours, and one hour prior to the myelogram, and BENADRYL 25-50 mg tablet 2 hours prior to the procedure. The physician ordering the myelogram will prescribe these for you.

Q. What are the risks of the procedure?
A.

The most common risk is a headache, which can be prevented and treated by rest and fluids. It is most likely to occur during the first 24 hours after, but may occur up to 3 days after the procedure. Other risks are less common, and will be discussed during the review of your consent form.

Q. What happens when the test is performed?
A. You will be on an x-ray table on your stomach for a study of the lower spine, or on your side for a study of the upper spine. X-ray guidance will be used to locate the site to access the spinal canal. Your skin will be numb from a local anesthetic, a thin needle will be placed to access the spinal fluid, then the dye will be injected. After this, a series of x-rays will be taken. This takes about one hour, and completes the myelogram portion of the procedure. You will then be monitored by the nursing staff, and will have a CT scan of the spine. You should expect to be in the hospital for a total of 3-4 hours.

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Sacral Biopsy

   Sacral biopsies can be performed with CT guidance. In the images below the lesion was a hemangioma but there was suspicion for a more aggressive process.

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Sialogram

(download Sialogram Patient Brochure in Acrobat PDF format)

   A sialogram is performed to diagnose blockage of the salivary flow due to stones or strictures. This examination is done by introducing a very thin tube into the opening of the duct and injecting a small amount of liquid. This probe procedure is done without any anesthesia since it is not too painful. It is a simple procedure usually completed in 30 minutes. Occasionally it can be difficult to the find the duct opening and in those cases the procedure with take longer.

   The adjacent image is a sialogram of the submandibular gland that demonstrates stricture of the duct. In this study, contrast material has been injected into the duct in the floor of the mouth. /smd/rad/neuroimages/sialonew.jpg
The adjacent image is a sialogram of the parotid gland with severe inflammatory changes. /neuroimages/sialo-parotid.jpg
This is an 8mm stone removed with a basket under radiologic control.

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Skull Biopsy

   A bone biopsy of skull lesions can be done percutaneously with CT guidance. Such a biopsy might be needed in patients who have a history of cancer and who develop new lesions seen on bone scan and/or CT scans. Via a mini incision, a bone trocar is used to obtain a bone biopsy of the suspected abnormal skull bone.

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Spinal Angiogram

neuroimages/spangio.jpg  A spinal angiogram is an x-ray study of the blood vessels supplying the spine. It is usually performed to look for abnormality of the vessels, so called vascular malformations. It may also be done to treat a vascular tumor or a vascular malformation.
   A spinal angiogram is done in an angiography suite with an x-ray machine. You will have to have fasted for 4 to 6 hours before the procedure. There will be a doctor and nurse and a radiologic technologist in the room. The groin is anesthetized with local anesthesia and the artery in the groin is punctured and a long fine catheter is feed up into the artery. The tip of the catheter is placed in the spinal arteries. Multiple views are needed with multiple injections of each of the spinal arteries.
   Spinal angiograms are often performed to evaluate for arteriovenous malformations related to the spinal cord. It can be done with MR imaging, but often conventional angiography is necessary for finer details.

Spinal angiography is a tedious process because there is one spinal artery for each rib and often you cannot tell before the study which artery is supplying the vascular malformation. During the procedure it is important to keep track of which injection represents which artery since the printed images look the same and there is no way to count on the individual images.
   In the images there is a case where we could use MR angiography to localize which artery was feeding the arteriovenous malformation, then we would have to do a conventional spinal digital subtraction angiography.


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Spine Biopsy

   If there is a suspicion for tumor or infection of the vertebral bodies, a biopsy is often needed. This can be done percutaneously with a needle using x-ray guidance. It is a minimally invasive procedure that yields diagnostic information in most cases with little complications.

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3D Reconstruction

   Using a special algorithm called maximal intensity projection we can create a semi-transparent image of the facial structure. This technique also eliminates practically all artifacts usually seen in CT scans where the patient has metallic dental fillings. We often use this technique for evaluation of facial fractures.

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