1997
Wu, H. and Huffer, F.W. (1997), "Modelling the Distribution of Plant Species Using Autologistic Regression Model," Environmental and Ecological Statistics, Vol. 4, No. 1, 49-64. (First Prize, Student Paper Awards by Section on Statistics and the Environment of ASA) pdf
George, E.O. and Wu, H. (1997), "Testing for Treatment Related Trend with Partially Exchangeable Clustered Data," Biometrics, 53, 479-487.
1998
Huffer, F.W. and Wu, H. (1998), "Markov Chain Monte Carlo in Spatial Binary Data Models with Application to the Distribution of Plant Species," Biometrics, 54, 509-524. pdf
Tan, W.Y. and Wu, H.(1998), "Stochastic Modeling the Dynamics of CD4+ T Cell Infection by HIV with Monte Carlo Studies," Mathematical Biosciences, 147, 173-205. pdf
Wu, H., Ding, A. and DeGruttola. V. (1998), "Estimation of HIV Dynamic Parameters," Statistics in Medicine, 17, 2463-2485. pdf
1999
Wu, H. and Ding, A. (1999), "Population HIV-1 Dynamics in Vivo: Applicable Models and Inferential Tools for Virological Data from AIDS Clinical Trials," Biometrics, 55, 410-418. pdf Data
Wu, H., Kuritzkes, D.R., and McClernon, D.R. et al. (1999), "Characterization of Viral Dynamics in Human Immunodeficiency Virus Type 1-Infected Patients Treated with Combination Antiretroviral Therapy: Relationships to Host Factors, Cellular Restoration and Virological Endpoints," Journal of Infectious Diseases, 179(4):799-807. pdf Data
Luzuriaga, K., Wu, H., and McManus, M. et al. (1999), "Dynamics of HIV-1 Replication in Vertically-Infected Infants," Journal of Virology, 73, 362-367.
Wu, H., Ding, A. and DeGruttola, V. (1999), "Why are the decay rates in plasma HIV-1 different for different treatments and in different patient populations?" AIDS, 13 (3): 429-430.
Wu, H. (1999), "How Frequently Should Viral Load be Monitored to Evaluate Antiretroviral Therapies in AIDS Clinical Trials?" Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 20, 97-99. pdf
Ding, A.A. and Wu, H. (1999), "Relationships between Antiviral Treatment Effects and Biphasic Viral Decay Rates in Modeling HIV Dynamics," Mathematical Biosciences, 160. 63-82. pdf Data
Wu, H., Ruan, P., Ding, A.A., Sullivan, J.L. and Luzuriaga, K. (1999), "Inappropriate Model-Fitting Methods May Lead To Significant Underestimates of Viral Decay Rates in HIV Dynamic Studies," Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 21, 426-428. pdf
Spear, GT, Olinger G, Sullivan B, Landay AL, Kessler, H, Connick E, Kuritzkes D, St. Clair M, Spritzler J, Wu H, Lederman MM (1999), "Alteration of complement proteins after antiretroviral therapy in HIV-infected persons," AIDS Research and Human Retroviruses, 15, 1713-15.
2000
Ding, A.A. and Wu, H. (2000), "A Comparison Study of Models and Fitting Procedures for Biphasic Viral Dynamics in HIV-1 Infected Patients Treated with Antiviral Therapies," Biometrics, 56, 293-300. pdf Data
Kuritzkes, D., Sevin A., Young, B., Bakhtiari, M., Wu, H., Clair, M.S., Connick, E., Landay, A.L., Spritzler, J., Kessler, H., and Lederman, M.M. (2000), "Presence of zidovudine resistance mutations does not prevent durable viral suppression by zidovudine/lamivudine/ritonavir," Journal of Infectious Diseases, 181, 491-497.
Wu, H. and Tan, W.Y. (2000), "Modeling HIV Epidemic: A State-Space Approach," Mathematical and Computer Modelling, 32, 197-215. (Epidemiology Young Investigator Award). pdf
2001
Ding, A.A. and Wu, H. (2001), "Assessing Antiviral Potency of Anti-HIV Therapies in Vivo by Comparing Viral Decay Rates in Viral Dynamic Models," Biostatistics, 2, 13-29. pdf
Wu, H. and Wu, L. (2001), "A Multiple Imputation Method for Missing Covariates in Nonlinear Mixed-effect Models, with Application to HIV Dynamics," Statistics in Medicine, 20 (12), 1755-1769. pdf
Wu, H., Connick E., Kuritzkes, D.R. et al. (2001), "Multiple CD4+ Cell Kinetic Patterns and Their Relationships with Baseline Factors and Virologic Responses in HIV-1 Patients Receiving HAART," AIDS Research and Human Retroviruses, 17(13), 1237-1246. pdf
2002
Wu, H. and Wu, L. (2002), "Identification of Significant Host Factors for HIV Dynamics Modeled by Nonlinear Mixed-Effect Models," Statistics in Medicine, 21, 753-771. pdf
Wu, H. and Ding, A.A. (2002), "Design of Viral Dynamic Studies for Efficiently Assessing Anti-HIV Therapies in AIDS Clinical Trials," Biometrical Journal, 2, 175-196. pdf
Wu, H. and Zhang, J.T. (2002), "Local Polynomial Mixed-Effects Models for Longitudinal Data," Journal of the American Statistical Association, 97, 883-897. pdf
Wu, L. and Wu, H. (2002), "Nonlinear Mixed-Effect Models with Missing Time-Dependent Covariates, with Application to HIV Viral Dynamics," Journal of the Royal Statistical Society, Series C (Applied Statistics), 51, 297-318. pdf
Wu, H. and Zhang, J.T. (2002), "The Study of Long-Term HIV Dynamics Using Semiparametric Nonlinear Mixed-Effects Models," Statistics in Medicine, 21, 3655-3675. pdf
2003
Liang, H., Wu, H., and Carroll, R.J. (2003), "The Relationship Between Virologic and Immunologic Responses in AIDS Clinical Research Using Mixed-Effects Varying-Coefficient Semiparametric Models with Measurement Error," Biostatistics, 4, 297-312. pdf
Hamzeh, F.M., Benson, C., Gerber, J., Currier, J., McCrea, J., Deutsch, P., Ruan, P., Wu, H., Lee, J., Flexner, C. (2003), "Steady-State Pharmacokinetic Interaction of Modified-Dose Indinavir and Rifabutin," Clinical Pharmacology and Therapeutics, 73, 159-169.
DiCenzo, R., Forrest, A., Squires, K.E., Hammer, S.M., Fischl, M.A., Wu, H., Cha, R., Morese, G.D. and the Adult AIDS Clinical Trials Group Protocol 368/886 Study Team (2003), "Indinavir, Efavirenz and Abacavir Pharmacokinetics in HIV-Infected Subjects," Antimicrobial Agents and Chemotherapy, 47, 1929-1935.
Sun, Y. and Wu, H. (2003), "AUC-Based Tests for Nonparametric Functions with Longitudinal Data, " Statistica Sinica, 13, 593-612. pdf
Huang, Y., Rosenkranz, S., Wu, H. (2003), "Modeling HIV Dynamics and Antiviral Responses with Consideration of Time-Varying Drug Exposures, Sensitivities and Adherence," Mathematical Biosciences, 184, 165-186. pdf
Wu, H., Mellors, J., Ruan, P. et al. (2003), "Viral Dynamics and Their Relations to Baseline Factors and Longer-Term Virologic Responses in Treatment-Naive HIV-1 Infected Patients Receiving Abacavir in Combination with HIV-1 Protease Inhibitors," JAIDS, 32, 557-564. pdf
Hass, D.W., Wu, H., Li, H. et al. (2003), "MDR1 Gene Polymorphisms and Phase-1 Viral Decay During HIV-1 Infection-An AACTG Study," JAIDS, 34, 295-298.
Zhang, Y., Liu, W., and Wu, H. (2003), "A Simple Nonparametric Two-Sample Test of the Failure Function with Interval Censored Data," Journal of Nonparametric Statistics, 15, 643-652. pdf
2004
Wu, H. and Liang, H. (2004), "Backfitting Random Varying-Coefficient Models with Time-dependent Smoothing Covariates," Scan. J. Statist., 31, 3-19. pdf
Wu, H., Lathey, J., Ruan, P., et al. (2004), "Relationship of Plasma HIV-1 RNA Dynamics to Baseline Factors and Virological Responses to Highly Active Antiretroviral Therapy (HAART) in Adolescents (Aged 12-22 Years) Infected Through Risk Behavior," Journal of Infectious Diseases, 189, 593-601. pdf
Wu, H., Zhao, C. and Liang, H. (2004), "Comparison of Linear, Nonlinear and Semiparametric Models for Estimating HIV Dynamic Parameters," Biometrical Journal, 46, 233-245. pdf
Acosta, EP, Wu, H., Hammer, SM, et al. (2004), "Comparison of Two Indinavir/Ritonavir Regimens in the Treatment of HIV-infected Individuals," JAIDS, 37, 2358-1366. pdf
2005
Wu, H., (2005), "Statistical Methods for HIV Dynamic Studies in AIDS Clinical Trials," Statistical Methods in Medical Research, 14, 171-192. pdf
Sun, Y. and Wu, H. (2005), "Semiparametric Time-Varying Coefficients Regression Model for Longitudinal Data," Scan. J. Statist., 32, 21-47. pdf
Wu, H., Huang, Y. and Acosta, E.P. et al. (2005), "Modeling Long-Term HIV Dynamics and Antiretroviral Response: Effects of Drug Potency, Pharmacokinetics, Adherence, and Drug Resistance," JAIDS, 39, 272-283. pdf
2006
Park, J.G. and Wu, H. (2006), "Backfitting and Local Likelihood Methods for Nonparametric Mixed-Effects Models with Longitudinal Data," Journal of Statistical Planning and Inference, 136, 3760-3782. pdf
Huang, Y. and Wu, H. (2006), "A Bayesian Approach for Estimating Antiviral Efficacy in HIV Dynamic Models," Journal of Applied Statistics, 33, 155-174. pdf
Huang, Y., Liu, D. and Wu, H. (2006), "Hierarchical Bayesian Methods for Estimation of Parameters in a Longitudinal HIV Dynamic System," Biometrics, 62, 413-423. pdf
Wu, H., Huang, Y. and Acosta, E.P. et al. (2006), "Pharmacodynamics of Antiretroviral Agents in HIV-1 Infected Patients Using Viral Dynamic Models That Incorporate Drug Susceptibility and Adherence." Journal of Pharmacokinetics and Pharmacodynamics , 33, 399-419. pdf
Wu, H., Huang, Y., Dykes, C., Liu, D., Ma, J., Perelson, A.S., Demeter, L. (2006), "Modeling and Estimation of Replication Fitness of HIV-1 in Vitro Experiments Using a Growth Competition Assay," Journal of Virology, 80, 2380-2389. pdf
Liu, D., J., Reichman, R., Chang, X., Wu, H., Jin, X. (2006), "Statisical Determination of Threshold for Cellular Division in the CFSE-Labeling Assay," Journal of Immunological Methods, 312, 126-136. pdf
Dykes, C., Wang, J., Planelles, V., An, D.S., Tallo, A., Huang, Y., Wu, H. Demeter, L.M., (2006), "Evaluation of Multiple-Cycle, Recombinant Virus, Growth Competition Assay that Uses Flow Cytometry to Measure Replication Efficiency of HIV-1 in Cell Culture," Journal of Clinical Microbiology, 44, 1930-1943. pdf
Treanor, J., Wu, H., Liang, H., and Topham, D.J. (2006), "Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults," Vaccine, 24, 6913-6923. pdf
2007
Jin, X., Wu, H., and Smith, H. (2007), "APOBEC3G Levels Predict Rates of Progression to AIDS," Retrovirology, 4:20. Paper
Palumbo,P., Wu, H., Chadwick E. et al. (2006), "Virologic Response to Potent Antiretroviral Therapy and Modeling HIV Dynamics in Early Pediatric Infection," The Journal of Infectious Diseases, 196, 23-29. pdf
Zhu, H. and Wu, H. (2007), "Estimation of Smoothing Time-Varying Parameters in State Space Models," Journal of Computational and Graphical Statistics (JCGS), 16, 813-832. pdf
Flanigan, R.M., Nawoczenski, D.A., Chen, L., Wu, H., and DiGiovanni, B.F. (2007), "The Influence of Foot Position on Stretching of the Plantar Fascia," Foot & Ankle, 28, 815-822.
2008
Huang, Y. and Wu, H. (2008), "Bayesian Experimental Design for Long-Term Longitudinal HIV Dynamic Studies," Journal of Statistical Planning and Inference, 138, 105-113. pdf
Wu, L., Hu, J.X., and Wu, H. (2008), "Joint Inference for Nonlinear Mixed-Effects Models and Time-to-Event at the Presence of Missing Data," Biostatistics, 9(2), 308-320. pdf
Chen, J. and Wu, H. (2008), "Efficient Local Estimation for Time-varying Coefficients in Deterministic Dynamic Models with Applications to HIV-1 Dynamics," Journal of the American Statistical Association, 103, 369-384. pdf
Wu, H., Zhu, H., Miao, H., and Perelson, A.S. (2008), "Parameter Identifiability and Estimation of HIV/AIDS Dynamic Models," Bulletin of Mathematical Biology, 70(3), 785-799. pdf
Miao, H., Dykes, C., Demeter, L.M., Cavenaugh, J., Park, S.Y., Perelson, A.S., and Wu, H. (2008), "Modeling and Estimation of Kinetic Parameters and Replicative Fitness of HIV-1 from Flow-Cytometry-Based Growth Competition Experiments," Bulletin of Mathematical Biology, 70, 1749-1771. pdf
Chen, J. and Wu, H. (2008), "Estimation of time-varying parameters in deterministic dynamic models with application to HIV infections," Statistica Sinica, 18, 987-1006. pdf supplement
Liang, H., Wu, H., and Zou, G. (2008), "A Note on Conditional AIC for Linear Mixed-Effects Models," Biometrika, 95, 773-778. pdf
Huang, Y., Liang, H., and Wu, H. (2008), "Identifying significant covariates for anti-HIV treatment response: mechanism-based differential equation models and empirical semiparametric regression models," Statistics in Medicine, 27, 4722-4739. pdf
Liang, H., and Wu, H. (2008), "Parameter Estimation for Differential Equation Models Using a Framework of Measurement Error in Regression Models," Journal of the American Statistical Association, 103, 1570-1583. pdf
2009
Miao, H., Dykes, C., Demeter, L., and Wu, H. (2009), "Differential Equation Modeling of HIV Viral Fitness Experiments: Model Identification, Model Selection, and Multi-Model Inference," Biometrics, 65, 292-300. pdf supplement
Eron, J.J., Park, J.G., Haubrich, R., Aweeka, F., Bastow, B., Pakes, G.E., Yu, S., Wu, H., and Richman, D.D. for the ACTG5126 Study Team (2009), Predictive Value of Pharmacokinetic-Adjusted Phenotypic Susceptibility on Response to Ritonavir-Enhanced Protease Inhibitors (PI) in HIV-Infected Subjects Failing Prior PI Therapy, Antimicrobial Agents and Chemotherapy, in press. pdf
Lee, H.Y., Hawkins, E., Zand, M.S., Mosmann, T., Wu, H., Hodgkin, P.D., Perelson, A.S. (2009), Interpreting CFSE Obtained Division Histories of B Cells in Vitro with Smith-Martin and Cyton Type Models, Bulletin of Mathematical Biology, in press. pdf
Lee, H.Y., Topham, D.J., Park, S.Y., Hollenbaugh, J., Treanor, J., Mosmann, T.R., Jin, X., Ward, B., Miao, H., Holden-Wiltse, J., Perelson, A.S., Zand, M., Wu, H. (2009), Simulation and Prediction of the Adaptive Immune Response to Influenza A Virus Infection, Journal of Virology, in press. pdf