EDUCATION

Ph.D.,Statistics, 1994, Department of Statistics, State University Tallahassee, Florida USA

M.S.,Statistics, 1991, Department of Statistics, Florida State University, Florida USA

M.S.,Engineering, 1987, Department of Automatic Control, National University of Defense Technology, P.R. China.

B.S., Engineering, 1984, Department of Automatic Control, National University of Defense Technology, P.R. China


POSITIONS AND APPOINTMENTS

2005-present, Director, Center for Biodefense Immune Modeling, University of Rochester Medical Center, Rochester, NY.

2004-present, Chief, Division of Biomedical Modeling and Informatics, Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY.

2004-present, Professor, Department of Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.

2004-present, Professor, Department of Community and Preventative Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.

2003-present, Professor, Department of Biostatistics and Computational Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.

2000-2003, Adjunct Lecturer, Department of Biostatistics, Harvard University, Boston MA USA.

2002-2003,Principal Research Scientist, Frontier Science & Technology Research Foundation (non-profit), Chestnut Hill, MA, USA.

1996-2002, Senior Statistical Scientist, Frontier Science & Technology Research Foundation (non-profit), Chestnut Hill, MA,USA.

1996-2002, Head, Pharmacology/Dynamic Modeling Section, SDAC/AACTG, Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA.

1994-1996, Visiting Assistant Professor, Department of Mathematical Sciences, University of Memphis, Memphis, TN, US.

1989-1994, Teaching Assistant, Department of Statistics, Florida State University, Tallahassee, FL, USA.

1987-1989, Engineer, Academy of Launch Vehicle Technology, Beijing , P.R. China.

AWARDS AND HONORS

  • Best First-Year Student Award (1990), Department of Statistics, Florida State University.
  • First Prize, Student Paper Awards, the 1993 Joint Statistical Meetings, San Francisco, Section on Statistics and the environment, American Statistical Association.
  • The ENAR Student Paper Award, the 1994 Spring Meetings, Cleveland, Ohio, the Eastern North American Region of the Biometrics Society (ENAR).
  • Ralph A. Bradley Award (for the most outstanding Ph.D graduate), 1994, Department of Statistics, Florida State University (FSU).
  • The Young Investigator Award, the 1995 Joint Statistical Meetings, Epidemiology Section, American Statistical Association.
  • Young Scientist Scholarship Fund Award, 1997, International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication, St. Petersburg, Florida.
  • The First Independent Research Support & Transition (FIRST) Awards, 1998-2003, National Institutes of Health (NIH).
  • Young Scientist Scholarship Fund Award, 1998, the 2nd International Workshop on HIV Drug Resistance and Treatment Strategies, Lake Maggiore, Italy.
  • Grant proposal review for Developmental Grants Program, Center for AIDS Research (CFAR), University of Washington, 2000.
  • Grant proposal review for Dutch AIDS Fund, Amsterdam, Netherlands, 2001.
  • Biocomputational Panel of the Information Technology Research Program, the National Science Foundation (NSF), 2003.
  • Center Grant Reviewer, National Institute on Drug Abuse, National Institutes of Health (NIH), 2005.
  • Grant proposal review for the section of Drug Discovery and Mechanisms of Antimicrobial Resistance, National Institutes of Health (NIH), 2005.

RESEARCH INTERESTS

  • Longitudinal Data: Nonparametric regression methods and mixed-effects models.
  • Statistical Methodologies: Markov chain Monte Carlo (MCMC), Bayesian methods.state-space models, measurement error models, missing data, and spatial statistics.
  • Computational Biology/Bioengineering: Clinical trial modeling and simulations, modeling HIV RNA/cellular dynamics, dynamic prediction of antiviral responses, and modeling AIDS and SARS epidemics.
  • Immunological modeling and data analysis.
  • Biomedical informatics.
  • Clinical Trials: AIDS clinical trials, HIV dynamic studies, pharmacokinetics and pharmacodynamics(PK/PD) trials.
  • Mathematical models of Immunity

RESEARCH GRANTS

  • Principal Investigator: NIH Grant R29 AI 43220, "Models and Inferential Tools for HIV-1 Dynamics in Vivo," funded (FIRST Award) by the National Institute of Allergy and Infectious Diseases/NIH, 1998-2003 (completed).
  • Principal Investigator: NIH Grant R01 AI 45356, "Modeling Cellular Kinetics in Treated HIV Patients," funded by the National Institute of Allergy and Infectious Diseases/NIH, 1999-2003 (completed).
  • Principal Investigator: NIH Grant R01 AI 52765, "Nonparametrical Modeling of Long-Term HIV/Cell Dynamics," funded by the National Institute of Allergy and Infectious Diseases/NIH, 2002-2006.
  • Principal Investigator: NIH Grant R01 AI 055290, "AIDS Clinical Trial Modeling and Simulations," funded by the National Institute of Allergy and Infectious Diseases/NIH, 2003-2008.
  • Principal Investigator & Director: NIH Center Grant Contract NOI-AI 50020,"Center for Biodefense Immune Modeling," Funded by NIAID/NIH, 2005-2010.
  • Co-Principal Investigator & Co-Director: Key Function of Biomedical Informatics, NIH Institutional Grant ULI RR024160, University of Rochester's Clinical and Translational Science Institute, NIH/NCRR, 2006-2011.