Ph.D. (1972) London University

David Oakes Professor of Biostatistics and Statistics     Contact Information: University of Rochester Dept of Biostatistics and Computational Biology 601 Elmwood Avenue Box 630 Rochester, New York 14642   Office: MRBX G-11128 Phone: (585) 275-2405 Fax: (585) 273-1031 E-mail: Oakes@bst.rochester.edu

Research Interests

After a period as Assistant Professor of Statistics at Harvard University I returned to London in 1977 as Senior Lecturer in Occupational Health Statistics at the London School of Hygiene and Tropical Medicine, where I became involved in the design and analysis of epidemiologic studies of cancer and respiratory diseases, and in the education of occupational health professionals.

Since coming to Rochester in 1983 I have become deeply involved in clinical trials. I direct the Biostatistics Centers of the Parkinson and Huntington Study Groups, two consortia of scientific investigators and researchers, committed to advancing knowledge about these diseases through the planning, implementation and reporting of clinical trials of promising therapeutic interventions. I have also worked in cardiology, infectious diseases and pediatrics, and am the Director of the Biostatistics Core facility for the Environmental Health Science Center at the University of Rochester. I am currently involved in several multicenter clinical trials and other initiatives in Parkinson's disease and Huntington's disease, and in a study of the influence of genetic polymorphisms on the risk of recurrent cardiac events after acute myocardial infarction.

At Rochester, I have taught courses in undergraduate probability and statistics and a variety of graduate level courses, including probability, stochastic processes, statistical inference, statistical modeling techniques and survival analysis. I have been involved in the education of medical students and fellows. I hold a training grant in environmental health sciences biostatistics and am co-director of a training grant in experimental therapeutics in neurology. I have Chaired the Departments of Statistics (1989-95) and of Biostatistics (1995-2002).

I have advised a total of eight graduate students, One (Ben Armstrong) is now a Reader in Epidemiological Statistics at London University, another (Amita Manatunga) is Associate Professor at Emory. Four others hold academic positions.

I am a Fellow of the American Statistical Association and an elected member of the International Statistical Institute. I serve on the NIH Study Section "Biostatistical Methods and Research Design" which reviews many grant applications in biostatistical methodology. I am the longest serving associate editor of the leading journal Biometrika (since 1979), and am one of three Editors of the journal Lifetime Data Analysis. I have authored or co-authored over 120 publications, About half of these are methodologic papers in the statistical and biostatistical literature and half are collaborative works, in recent years mostly in Neurology journals. A selection of the methodologic papers is given below. For a full c.v., which includes a complete list of all my publications, click here.

Selected References

• Oakes, D. (1977). The asymptotic information in censored survival data. Biometrika 64, 441-448.
• Oakes, D. (1981). Survival times: aspects of partial likelihood (with discussion). International Statistical Review 49, 235-264.
• Cox, D.R. and Oakes, D. (1984). Analysis of Survival Data. London, Chapman and Hall.
• Oakes, D. (1989). Bivariate survival models induced by frailties. Journal of the American Statistical Association 84, 487-493.
• Oakes, D. and Dasu, T. (1990). A note on residual life. Biometrika 77, 409-410.
• Oakes, D. and Manatunga, A.K. (1992). Fisher information for a bivariate survival distribution. Biometrika 79, 827-832.
• Oakes, D., Moss, A. J., Fleiss, J.L., Bigger, J.T., Therneau, T., Eberly, S.W., McDermott, M.P., Manatunga. A., Carleen, E., Benhorin, J. and the MultiCenter Diltiazem Postinfarction Trial Research Group (1993). Use of compliance measures in an analysis of the effect of diltiazem on mortality and reinfarction after myocardial infarction. Journal of the American Statistical Association 88, 44-49.
• Oakes, D. and Cui, L. (1994). A note on semiparametric inference for modulated renewal processes. Biometrika 81, 83-90.
• Oakes, D. (1995). Multiple Time Scales in Survival Analysis. Lifetime Data Analysis 1, 7-20.
• Oakes, D. (1999). Direct calculation of the information matrix via the EM algorithm. Journal of the Royal Statistical Society, Series B 61, 479-482.
• Oakes, D. and Manatunga, A.K. (1999). Parametric analysis for matched pairs survival data. Lifetime Data Analysis 5, 371-387.
• Oakes, D. (2000). Survival Analysis (Vignette). Journal of the American Statistical Association 95, 282-285.
• Oakes, D. (2001). Biometrika Centenary: Survival Analysis. Biometrika 88, 99-142.
• McDermott, M.P., Hall, W.J., Oakes, D. and Eberly, S.W. (2002). Design and analysis of two-period studies of potentially disease-modifying treatments. Controlled Clinical Trials 23, 635-649.
• Kolassa, J.E. and Oakes, D. (eds.) (2003). Crossing Boundaries: Statistical Essays in Honor of Jack Hall. Institute of Mathematical Statistics Lecture Notes, Monographs Series #43.
• Jeong, J.H. and Oakes, D. (2003). On the asymptotic relative efficiency of estimates from Cox's model. Sankhya 65, 422-438.