 Ph.D.
(1983) |
Dwight
Hardy
Associate Professor of Microbiology & Immunology Primary Appointment: GEBS
Cluster Affiliations: |
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| Contact Information: | ||
| University
of Rochester School of Medicine and Dentistry 601 Elmwood Ave, Box 672 Rochester, New York 14642 |
Medical Center 2-5235 Phone: (585) 275-1408 Fax: (585) 473-9573 E-Mail: dwight_hardy@urmc.rochester.edu |
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- Research Focus
- Antimicrobial Susceptibility and Resistance
- Research Overview
- Resistance to antimicrobial agents in long-recognized bacterial pathogens, e.g., staphylococci, pneumococci, and gonococci, and newly recognized pathogens, e.g., enterococci, underscores the need for continuing efforts at detecting and characterizing drug resistance. The correlation of results produced by different in vitro test methodologies and their ability to accurately detect resistance to antimicrobial agents is an interest of my laboratroy. My laboratory is also studying Neisseria gonorrhoeae for the emergence of resistance to beta-lactam drugs by non-beta-lactamase mediated mechanism(s) and resistance to quinolones.
- Several phenotypic and genotypic techniques for studying the epidemiology of bacterial infections and determination of strain relatedness have been described. Genotypic characterization of organisms offers greater discrimination than phenotypic characterization for determination of strain relatedness. Molecular methods which involve macrorestriction of chromosomal DNA are the most discriminating of currently available genotypic methods. Application of these techniques to problems of clinical microbiology, infection control and epidemiology of hospital- and community-acquired infections is an interest of my laboratory. Pulsed-field gel electrophoresis has been used to investigate the epidemiology of methicillin-resistant Staphylococcus aureus within our hospital and the appearance in our community of Shigella sonnei with new drug resistance. The use of these techniques provides a greater understanding of the molecular epidemiology of drug resistance.
- Recent Publications
- McNanley AR, Glantz JC, Hardy DJ, Vicino D "The effect of intrapartum penicillin on vaginal group B streptococcus colony counts." Am J Obstet Gynecol. 2007 Dec;197(6):583.e1-4
- Swenson JM, Brasso WB, Ferraro MJ, Hardy DJ, Knapp CC, McDougal LK, Reller LB, Sader HS, Shortridge D, Skov R, Weinstein MP, Zimmer BL, Patel JB "Detection of Inducible Clindamycin Resistance in Staphylococci by Broth Microdilution Using Erythromycin/Clindamycin Combination Wells." J Clin Microbiol. 2007 Dec;45(12):3954-7
- Cholette JM, Caserta M, Hardy D, Connolly HV. "Outcome of pulmonary function in Lemierre's disease-associated acute respiratory distress syndrome." Pediatr Pulmonol. 2007 Feb 28;
- Elhassan NO, Stevens TP, Gigliotti F, Hardy DJ, Cole CA, Sinkin RA. "Vancomycin usage in central venous catheters in a neonatal intensive care unit." Pediatr Infect Dis J. 23:201-6, 2004.
- Bruckner LB, Korones DN, Karnauchow T, Hardy DJ, Gigliotti F. High incidence of penicillin resistance among alpha-hemolytic streptococci isolated from the blood of children with cancer. J Pediatr. 140:20-6, 2002.
- Hardy D, Amsterdam D, Mandell LA, Rotstein C. Comparative in vitro activities of ciprofloxacin, gemifloxacin, grepafloxacin, moxifloxacin, ofloxacin, sparfloxacin, trovafloxacin, and other antimicrobial agents against bloodstream isolates of gram-positive cocci. Antimicrob Agents Chemother. 44:802-5, 2000.
- Fernandes PB, Menzel R, Hardy DJ, Tse-Dinh YC, Warren A, Elsemore DA. Microbial resistance: novel screens for a contemporary problem. Med Res Rev 19:559-68, 1999.
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