Selected Publications

Ramirez SH, Fan S, Maguire CA, Perry S, Hardiek K, Ramkumar V, Gelbard HA, Dewhurst S, Maggirwar SB. Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal. J Neurosci Res. 77:258-69, 2004.

Zhen Z, Bradel-Tretheway BG, Dewhurst S, Bidlack JM. Transient overexpression of kappa and mu opioid receptors using recombinant adenovirus vectors. J Neurosci Methods 136:133-9, 2004.

Latchney LR, Fallon MA, Culp DJ, Gelbard HA, Dewhurst S. Immunohistochemical Assessment of Fractalkine, Inflammatory Cells, and Human Herpesvirus 7 in Human Salivary Glands. J Histochem Cytochem. 52:671-682, 2004.

Dou H, Birusingh K, Faraci J, Gorantla S, Poluektova LY, Maggirwar SB, Dewhurst S, Gelbard HA, Gendelman HE. Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis. J Neurosci. 23:9162-70, 2003.

Diamond TL, Souroullas G, Weiss KK, Lee KY, Bambara RA, Dewhurst S, Kim B. Mechanistic understanding of an altered fidelity simian immunodeficiency virus reverse transcriptase mutation, V148I, identified in a pig-tailed macaque J Biol Chem. 278:29913-24, 2003.

Bradel-Tretheway BG, Zhen Z, Dewhurst S. Effects of codon-optimization on protein expression by the human herpesvirus 6 and 7 U51 open reading frame. J Virol Methods 111:145-56, 2003.

Wang X, Messerle M, Sapinoro R, Santos K, Hocknell PK, Jin X, Dewhurst S. Murine cytomegalovirus abortively infects human dendritic cells, leading to expression and presentation of virally vectored genes J. Virol. 77:7182-7192, 2003.

Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff HJ, Dewhurst S. Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine 21:2288-2297, 2003

Richards J, Abend J, Miller M, Chakraborty-Sett S, Dewhurst S, Whetter L. A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells. Eur. J. Biochem. 270: 2287-2294, 2003.

Richards J, Miller M, Abend J, Koide A, Koide S, Dewhurst S. Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphaV beta3 integrin. J. Mol. Biol. 326:1475-1488, 2003.

Hocknell PK, Wiley RW, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst, S. Expression of human immunodeficiency virus-1 gp120 from herpes simplex virus-1 derived amplicons results in potent, specific and durable cellular and humoral immune responses. J. Virol. 76:5565-5580, 2002.

Skrincosky D, Willis RA, Hocknell PK, Frelinger JG, Mirandola P, Wang X, Dewhurst S. Epitope mapping of human herpesvirus-7 gp65 using monoclonal antibodies. Arch. Virol. 146:1705-1722, 2001.

Ramirez SH, Sanchez JF, Dimitri CA, Gelbard HA, Dewhurst S, Maggirwar SB. Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism. J. Neurochem. 78:874-889, 2001.

Tong N, Sanchez JF, Maggirwar SB, Ramirez SH, Guo H, Dewhurst S, Gelbard HA. Activation of glycogen synthase kinase (GSK)-3 beta by platelet activating factor mediates migration and cell death in cerebellar granule neurons. Eur J Neurosci. 13:1913-1922, 2001

Bal HP, Chroboczek J, Schoehn G, Ruigrok RW, Dewhurst S. Adenovirus type 7 penton - Purification of soluble pentamers from Escherichia coli and development of an integrin-dependent gene delivery system. Eur J Biochem. 267:6074-6081, 2000.

Skrincosky D, Hocknell P, Whetter L, Secchiero P, Chandran B, Dewhurst S. Identification and analysis of a novel heparin-binding glycoprotein encoded by human herpesvirus 7. J Virol. 74:4530-40, 2000.

Maggirwar SB, Ramirez S, Tong N, Gelbard HA, Dewhurst S. Functional interplay between nuclear factor-kappaB and c-Jun integrated by coactivator p300 determines the survival of nerve growth factor-dependent PC12 cells. J. Neurochem. 74:527-39, 2000.

Tong N, Perry SW, Zhang Q, James HJ, Guo H, Brooks A, Bal H, Kinnear SA, Fine S, Epstein LG, Dairaghi D, Schall TJ, Gendelman HE, Dewhurst S, Sharer LR, Gelbard HA. Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. J. Immunol. 164:1333-9, 2000.

Maggirwar SM, Tong N, Ramirez S, Gelbard HA, Dewhurst S. HIV-1 Tat mediated activation of glycogen synthase kinase-3 beta contributes to Tat-mediated neurotoxicity. J Neurochem 73:578-586, 1999.

Dominguez G, Dambaugh TR, Stamey FR, Dewhurst S, Inoue I, Pellett PE. Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. J Virol 73:8040-8051, 1999.

Maggirwar SM, Sarmiere PD, Dewhurst S, Freeman RS. Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons. J Neurosci 18:10356-10365, 1998.

Deng H, Dewhurst, S. Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6. J Virol 72:320-329, 1998.

Selected Review Articles

Dewhurst S. HHV-6 and HHV-7 Infections of the Central Nervous System. In: Herpesvirus Infections of the CNS. International Herpesvirus Management Foundation (IHMF) Monograph, 2003.

Perry SW, Dewhurst S, Bellizzi MJ, Gelbard HA. Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk? J Neurovirol. 8:611-24, 2002.

Caserta MT, Mock DJ, Dewhurst S. Human herpesvirus 6. Clin. Infect. Dis. 33:829-833, 2001.

Dewhurst SL, da Cruz RL, Whetter L. Pathogenesis and treatment of HIV-1 infection: recent developments (Y2K update). Front Biosci. 5:D30-49, 2000.

Whetter L, Ojukwu I, Novembre F, Dewhurst S. Pathogenesis of simian immunodeficiency virus infection. J Gen Virol 80:1557-1568, 1999.

Dewhurst S, Skrincosky D, van Loon N. Human herpesvirus 7. Expert Reviews in Molecular Medicine, 1997.