 Ph.D. (1982) |
Constantine
G. Haidaris
Associate
Professor of Microbiology &
Immunology
and of Oral Biology Primary
Appointment: GEBS
Cluster Affiliations: |
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| Contact Information | ||
| University
of Rochester School of Medicine and Dentistry 601 Elmwood Ave, Box 672 Rochester, New York 14642 |
Phone:
(585) 275-0678 E-Mail: Constantine_Haidaris @urmc.rochester.edu |
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- Research Overview
- My laboratory research focuses on the eukaryotic opportunistic pathogens Pneumocystis carinii and Candida albicans. Pneumocystis carinii causes a fatal pneumonia in the immunocompromised host. Our studies focus on gene expression in the microbe, utilizing recombinant DNA methodology and protein biochemistry. We have been isolating the genes encoding the immunodominant surface glycoprotein antigens of P. carinii and characterizing them at the level of RNA expression and gene structure. Furthermore, we have utilized eukaryotic geneexpression systems to produce recombinant forms of the antigens for immunological and functional studies. We anticipate that furthering our understanding of the biology of P. carinii and characterizing its antigens will allow us to deduce mechanisms of acquired immunity to P. carinii infection.
- Candida albicans is an opportunistic fungus that infects a wide variety of anatomical sites, the most prevalent of which are epithelial surfaces. Current work utilizes small molecules to target the organism in the context of infection.
- Recent Publications
- Wellington M, Dolan K, Haidaris CG "Monocyte responses to Candida albicans are enhanced by antibody in cooperation with antibody-independent pathogen recognition." FEMS Immunol Med Microbiol. 2007 Oct;51(1):70-83
- Wellington M, Dolan K, Haidaris CG "Monocyte responses to Candida albicans are enhanced by antibody in cooperation with antibody-independent pathogen recognition." FEMS Immunol Med Microbiol. 2007 Jul 4;
- Van Alst NE, Picardo KF, Iglewski BH, Haidaris CG "Nitrate sensing and metabolism modulates motility, biofilm formation, and virulence in Pseudomonas aeruginosa." Infect Immun. 2007 May 25;
- Wells J, Haidaris CG, Wright TW, Gigliotti F. "Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen." Infect Immun. 2006 Apr;74(4):2446-8.
- Wells J, Haidaris CG, Wright TW, Gigliotti F. "Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia." Infect Immun. 2006 Jan;74(1):390-3.
- Chabrier-Rosello Y, Foster TH, et al "Sensitivity of Candida albicans germ tubes and biofilms to photofrin-mediated phototoxicity." Antimicrob Agents Chemother. 2005 Oct;49(10):4288-95.
- Filiatrault MJ, Wagner VE, et al. "Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa." Infect Immun. 2005 Jun;73(6):3764-72.
- Disney MD, Stephenson R, et al. "Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis." Antimicrob Agents Chemother. 2005 Apr;49(4):1326-30.
- Burns, R., I. Luzina, et al. "Keratinocyte-derived, CD80-mediated costimulation is associated with hapten-specific IgE production during contact hypersensitivity to TH1 haptens." J Allergy Clin Immunol 115(2): 383-90, 2005.
- Wells J, Gigliotti F, Simpson-Haidaris PJ, Haidaris CG. "Epitope mapping of a protective monoclonal antibody against Pneumocystis carinii with shared reactivity to Streptococcus pneumoniae surface antigen PspA." Infect Immun. 72:1548-56, 2004.
- Bliss JM, Bigelow CE, Foster TH, Haidaris CG. Susceptibility of Candida species to photodynamic effects of photofrin. Antimicrob Agents Chemother. 48:2000-6, 2004.
- Wellington M, Bliss JM, Haidaris CG. Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment. Infect Immun. 71:7228-31, 2003.
- Bliss JM, Sullivan MA, Malone J, Haidaris CG. Differentiation of Candida albicans and Candida dubliniensis by using recombinant human antibody single-chain variable fragments specific for hyphae. J Clin Microbiol. 41:1152-60, 2003.
- Board KF, Patil S, Lebedeva I, Capuano S 3rd, Trichel AM, Murphey-Corb M, Rajakumar PA, Flynn JL, Haidaris CG, Norris KA. Experimental Pneumocystis carinii pneumonia in simian immunodeficiency virus-infected rhesus macaques. J Infect Dis. 187(4):576-88, 2003.
- Disney MD, Haidaris CG, Turner DH. Uptake and antifungal activity of oligonucleotides in Candida albicans. Proc Natl Acad Sci U S A. 100:1530-4, 2003.
- Croix DA, Board K, Capuano S 3rd, Murphey-Corb M, Haidaris CG, Flynn JL, Reinhart T, Norris KA. Alterations in T lymphocyte profiles of bronchoalveolar lavage fluid from SIV- and Pneumocystis carinii-coinfected rhesus macaques. AIDS Res Hum Retroviruses. 18:391-401, 2002.
- Gigliotti F, Haidaris CG, Wright TW, Harmsen AG. Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia. Infect Immun. 70:1069-74, 2002.
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