 M.D. (1976) | Michael
Pichichero Professor of Microbiology & Immunology Primary
Appointment: GEBS
Cluster Affiliations: |
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| Contact Information: | ||
| University
of Rochester School of Medicine and Dentistry 601 Elmwood Ave, Box 672 Rochester, New York 14642 | Medical
Center 2-5431 Phone: (585) 275-1534 E-Mail: michael_pichichero @urmc.rochester.edu | |
- Research Focus
- Vaccine Development and Evaluation
- Research Overview
- Dr. Pichichero was a member of the discovery team at the University of Rochester that invented, tested and licensed a Haemophilus influenzae b (Hib) conjugate vaccine (HibTITER®) now universally given to children in the U.S. This “conjugate” vaccine technology was used in the subsequent development of another universally-given vaccine- the pnuemococcal conjugate vaccine (Prevnar®). Dr. Pichichero has played a role in the clinical and/or translational research leading to licensure of many vaccines including acellular pertussis vaccines (DTaP), combination vaccines (DTaP-Hib-polio and DTaP-Hepatitis B-polio), meningococcal conjugate vaccine, Rotavirus vaccine, Human papillomavirus vaccine, adolescent Tdap vaccines and others.
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Now Dr. Pichichero is leading a research team of scientists at the UR working toward the development
of a multi-component vaccine to prevent ear, sinus and lung infections caused by pneumococci and
non-typeable H. influenzae. The approach is multi-focused including:
- The study of natural infection and asymptomatic colonization with these bacteria in children.
- Evaluation of serum and mucosal antibody; generation of B memory cell and T cell responses to disease, colonization and vaccine candidates.
- Molecular epidemiology.
- Vaccine antigen discovery.
- The Pichichero lab also collaborates with vaccine companies, international scientists, federally funded investigators, the NIH, FDA, CDC and WHO to characterize immunogenicity and efficacy of vaccines.
- Recent Publications
- Xu Q, Pichichero ME, Simpson LL, Elias M, Smith LA, Zeng M An adenoviral vector-based mucosal vaccine is effective in protection against botulism. Gene Ther. 2009 Jan 8;
Pichichero ME, Casey JR, Hoberman A, Schwartz R Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006. Clin Pediatr (Phila). 2008 Nov;47(9):901-6
Xu Q, Arevalo MT, Pichichero ME, Zeng M A new complementing cell line for replication-incompetent E1-deleted adenovirus propagation. Cytotechnology. 2006 Jul;51(3):133-40
Pichichero ME, Doern GV, Kuti JL, Nicolau DP Pichichero ME Probability of Achieving Requisite Pharmacodynamic Exposure for Oral beta-Lactam Regimens against Haemophilus influenzae in Children. Paediatr Drugs. 2008;10(6):391-7
Vaccine-induced immunologic memory and pace of pathogenesis: predicting the need for boosters. Expert Rev Vaccines. 2008 Nov;7(9):1299-1303
Pichichero ME, Casey JR Diagnostic Inaccuracy and Subject Exclusions Render Placebo and Observational Studies of Acute Otitis Media Inconclusive. Pediatr Infect Dis J. 2008 Oct 7; - Casey JR, Kahn R, Gmoser D, Atlas E, Urbani K, Luber S, Pellman H, Pichichero ME Frequency of Symptomatic Relapses of Group A {beta}-Hemolytic Streptococcal Tonsillopharyngitis in Children from 4 Pediatric Practices Following Penicillin, Amoxicillin, and Cephalosporin Antibiotic Treatment. Clin Pediatr (Phila). 2008 May 19;
- Noel GJ, Blumer JL, Pichichero ME, Hedrick JA, Schwartz RH, Balis DA, Melkote R, Bagchi P, Arguedas A A Randomized Comparative Study of Levofloxacin Versus Amoxicillin/Clavulanate for Treatment of Infants and Young Children With Recurrent or Persistent Acute Otitis Media. Pediatr Infect Dis J. 2008 Apr 30;
- Pichichero ME, Casey JR Comparison of study designs for acute otitis media trials. Int J Pediatr Otorhinolaryngol. 2008 Apr 7;
- Pichichero ME Improving Vaccine Delivery Using Novel Adjuvant Systems. Hum Vaccin. 2008 Feb 15;4(4)
- Pichichero ME, Casey JR Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era. Pediatr Infect Dis J. 2007 Oct;26(10 Suppl):S12-6
- Pichichero ME, Casey JR, Block SL, Guttendorf R, Flanner H, Markowitz D, Clausen S Pharmacodynamic Analysis and Clinical Trial of Amoxicillin Sprinkle QD for 7 Days Compared to Penicillin VK QID for 10 Days in the Treatment of Tonsillopharyngitis due to Streptococcus Pyogenes in Children. Antimicrob Agents Chemother. 2008 Mar 10
- Zeng M, Xu Q, Elias M, Pichichero ME, Simpson LL, Smith LA Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine.Vaccine. 2007 Oct 23;25(43):7540-8
- Pichichero ME, Gentile A, Giglio N, Umido V, Clarkson T, Cernichiari E, Zareba G, Gotelli C, Gotelli M, Yan L, Treanor J " Mercury levels in newborns and infants after receipt of thimerosal-containing vaccines." Pediatrics. 2008 Feb;121(2):e208-14
- Pichichero ME, Casey JR "Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era." Pediatr Infect Dis J. 2007 Oct;26(10 Suppl):S12-6
- Pichichero ME, Casey JR "Systematic review of factors contributing to penicillin treatment failure in Streptococcus pyogenes pharyngitis" Otolaryngol Head Neck Surg. 2007 Dec;137(6):851-857
- Casey JR, Pichichero ME "Symptomatic relapse of group A beta-hemolytic streptococcal tonsillopharyngitis in children." Clin Pediatr (Phila). 2007 May;46(4):307-10
- Pichichero ME, Casey JR "Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children." JAMA. 2007 Oct 17;298(15):1772-8
- Pichichero ME, Casey JR "Bacterial eradication rates with shortened courses of 2nd- and 3rd-generation cephalosporins versus 10 days of penicillin for treatment of group A streptococcal tonsillopharyngitis in adults." Diagn Microbiol Infect Dis. 2007 Oct;59(2):127-30
- Zeng M, Xu Q, Elias M, Pichichero ME, Simpson LL, Smith LA "Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine." Vaccine. 2007 Sep 5;
- Pichichero ME "Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift." Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):13S-18S
- Casey JR, Pichichero ME. "The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis." Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):39S-45S
- Denoël PA, Goldblatt D, de Vleeschauwer I, Jacquet JM, Pichichero ME, Poolman JT "Quality of the Haemophilus influenzae type b antibody response induced by DTPa/Hib combination vaccines." Clin Vaccine Immunol. 2007 Aug 15;
- Pichichero ME "The Importance of Bacteriologic Eradication in the Treatment of Group A Streptococcal Tonsillopharyngitis." Clin Pediatr (Phila). 2007 May;46(4_suppl):3S-16S
- Casey JR, Pichichero ME. "Symptomatic Relapse of Group A {beta}-Hemolytic Streptococcal Tonsillopharyngitis in Children." Clin Pediatr (Phila). 2007 May;46(4):307-10
- Pichichero ME "Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift." Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):S13-8
- Pichichero ME. "Who should get the HPV vaccine?" J Fam Pract. 2007 Mar;56(3):197-202
- Casey JR, Pichichero ME. "Safe use of selected cephalosporins in penicillin-allergic patients: A meta-analysis." Otolaryngol Head Neck Surg. 2007 Mar;136(3):340-7.
- Casey JR, Pichichero ME. "The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis." Diagn Microbiol Infect Dis. 2007 Feb 8;
- Zeng M, Xu Q, Pichichero ME. "Protection against anthrax by needle-free mucosal immunization with human anthrax vaccine." Vaccine. 2007 Jan 26;
- Pichichero ME, Casey JR, Francis AB, Marsocci SM, Murphy M, Hoeger W, Cleary C. "Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules." Clin Pediatr (Phila). 2006 Sep;45(7):613-20.
- Farrell DJ, Klugman KP, Pichichero M. "Increased Antimicrobial Resistance Among Nonvaccine Serotypes of Streptococcus pneumoniae in the Pediatric Population After the Introduction of 7-Valent Pneumococcal Vaccine in the United States." Pediatr Infect Dis J. 2007 Feb;26(2):123-128.
- Arguedas A, Dagan R, Pichichero M, Leibovitz E, Blumer J, McNeeley DF, Melkote R, Noel GJ "An Open-Label, Double Tympanocentesis Study of Levofloxacin Therapy in Children With, or at High Risk for, Recurrent or Persistent Acute Otitis Media." Pediatr Infect Dis J. 2006 Dec;25(12):1102-1109
- Pichichero M, Papa T, Blatter M, Mitchell D, Kratz R, Sneed J, Bassily E, Casey J, Gilmet G "Immune Memory in Children Previously Vaccinated With an Experimental Quadrivalent Meningococcal Polysaccharide Diphtheria Toxoid Conjugate Vaccine." Infect Dis J. 2006 Nov;25(11):995-1000
- Pichichero ME, Casey JR, Francis AB, Marsocci SM, Murphy M, Hoeger W, Cleary C "Acellular Pertussis Vaccine Boosters Combined With Diphtheria and Tetanus Toxoid Boosters for Adolescents: Safety and Immunogenicity Assessment When Preceded by Different 5-Dose DTaP/DTwP Schedules." Clin Pediatr (Phila). 2006 Sep;45(7):613-20
- Pichichero ME, Pathogen shifts and changing cure rates for otitis media and tonsillopharyngitis Clin Pediatr (Phila). 2006 Jul-Aug;45(6):493-502
- Pichichero ME, Prevention of cervical cancer through vaccination of adolescents. Clin Pediatr (Phila). 2006 Jun;45(5):393-8
- Pichichero M, "Rotavirus Vaccine (RotaTeq((R))): A Viewpoint by Michael E. Pichichero" Paediatr Drugs. 2006; 8(3):203-4
- Pichichero M, Casey J. "Comparison of European and U.S. results for cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis." Eur J Clin Microbiol Infect Dis. 2006 Jun;25(6):354-64
- Pichichero ME, Wright T. "The use of tympanocentesis in the diagnosis and management of acute otitis media." Curr Infect Dis Rep. 2006 May;8(3):189-95.
- Pichichero ME, DeTora LM, Johnson DR. "An adolescent and adult formulation combined tetanus, diphtheria and five-component pertussis vaccine." Expert Rev Vaccines. 2006 Apr;5(2):175-87.
Publication
list, as provided by PubMed.
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and provides complete abstracts of all publications,
as well as links
to the full text of many articles (at journal homepages).