A subset of faculty study human sensori-motor systems. What cannot be addressed at the level of cells and circuits is countered by other advantages. First, functional imaging now provides powerful tools to link human neurobiology with mechanistic approaches established in animal research. Second, the efficiency of engaging humans in a sensori-motor research environment opens extraordinary options for the investigation of perception and its associations with raw sensory input and motor action in ways that are difficult if not impossible in other species. It is the blending of species and technologies that we believe provides a unique and synergistic opportunity to investigate and ultimately understand a variety of complex neural functions. Toward that goal, we have established a set of state-of-the-art laboratories for the quantitative study of integrative neural function in humans. Our version of human neurobiology combines psychophysics with neurophysiology and functional anatomy, and links these with expertise in biomedical engineering, computational/theoretical neurobiology, and clinical disciplines.