Symposia:
Berislav Zlokovic, M.D., Ph.D.--Intravascular Alzheimer's amyloid-B Linked to AB Deposition in the Brain
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Dr. Zlokovic's research links intravascular Alzheimer's amyloid-B (AB) to AB deposition in the brain, transport across the blood brain barrier, (BBB) and neuroinflammation as a primary mechanism in Alzheimer's disease pathogenesis. Faulty clearance due to dysregulated transport of AB is shown to potentiate neuroinflammation and cerebral B - amyloidosis associated with reduced cerebral blood flow (CBF), triggering "silent strokes" in models of Alzheimer's disease. From the therapeutic prospective, his investigations show that new peripheral AB binding agents protect brain from AB / amyloid accumulation, neuroinflammation and suppression of CBF. In addition, his work on activated protein C (APC) in the CNS demonstrates that APC prevents leukocyte trafficking across the BBB and protects brain from injury and/or apoptosis. |
| Dr. Zlokovis is Professor and Associate Chair, Neurosurgery; Director, Frank P. Smith Laboratories for Neurosurgical Research and Neuroscience; University of Rochester Medical Center |
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