Julie Fudge, M.D.

Academic and Clinical Appointments

Associate Professor of Psychiatry and Neurobiology and Anatomy

Contact Information

Education

Professional Overview

Dr. Fudge is an Associate Professor of Psychiatry, with a secondary appointment in the Dept. of Neurobiology and Anatomy. She studies the anatomy and neurochemistry of brain regions associated with symptoms in major psychiatric illnesses such as schizophrenia and mood disorders. Her studies include the role of the amygdala in aberrant emotional processing which plays a key role in symptoms such as psychosis, and the severe mood and anxiety disorders.  Her areas of interest include the afferent influence of the amygdala and related limbic structures on the dopamine system, and defining new limbic regions of the striatum based on amygdaloid inputs.  Ongoing studies also include identifying amygdaloid subregions whose molecular and connectional features place them in a vulnerable position for aberrant plastic changes after exposure to chronic stress.  These studies are conducted in collaboration with other members of the Laboratory for Stress and Resilience in the Department of Psychiatry (Mind-Body Center), which focuses on mechanisms of stress response and successful coping across species. 

Selected Publications

Fudge JL; Powers JM; Haber SN; Caine ED.Considering the role of the amygdala in psychotic illness: a clinicopathologic correlation. Journal of Neuropsychiatry and Clinical Neurosciences; (Special Article) 10:383-394, 1998

Haber SN; Fudge JL, McFarland, NR. Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. J. Neurosci.; 20:2369-2382.

Fudge JL; Haber SN. The central nucleus of the amygdala projection to dopamine subpopulations in primates. Neuroscience, 97(3): 479-494, 2000.

Fudge JL; Haber SN. Bed nucleus of the stria terminalis and extended amygdala inputs to dopamine subpopulations in primates: implication for motivated behaviors. Neuroscience (accepted), 2001

Fudge JL, Kunishio K, Walsh P, Richard C, Haber SN. Amygdaloid projections to ventromedial striatal subterritories in the primate. Neuroscience. 110 (2): 257-275, 2002.

Fudge, JL and Haber, SN. Defining the caudal ventral striatum in primates: cytoarchitectural and histochemical features. J. Neuroscience 22(23): 10078-10082, 2002.

Fudge, JL, Song, DD, Haber, SN. A partial dopamine lesion impairs performance on a procedural learning task: implications for Parkinson¹s
disease. International Basal Ganglia Society, VI. (Editor: Ann Graybiel), 65-75, 2002.

Fudge, JL and Reid, A. The extended amygdala and the dopamine system: another piece of the dopamine puzzle. Journal of Neuropsychiatry and Clinical Neurosciences (Special Article) 15:306-316, Summer 2003

Emiliano, A.B.F. and Fudge, J.L. From osteopenia to galactorrhea: rethinking serotonin-prolactin interactions. Neuropsychopharmacology,
29(5):833-846, 2004

Fudge, JL, Breitbart, MA, and McClain, CR. Amygdaloid inputs define a caudal component o the Œclassic¹ ventral striatum in primates. J. Comp. Neurol. 476: 330-347, 2004

Fudge, J.L.. Bcl-2 immunoreactive neurons are differentially distributed in subregions of the amygdala and hippocampus of the adult Macaque. Neuroscience 127 (2): 539-556, 2004.

Fudge, JL, Breitbart, MA, Pannoni, V, Danish, ML.  Insular projections to the caudal ventral striatum in the primate.  J. Comp. Neurol. 240: 101-118, 2005.

O’Rourke, H.  and Fudge, JL. Distribution of 5-HTT labeled fibers in amygdaloid subregions: implications for mood disorders. Biol. Psychiatry 60 (5):  479-490, 2006.

Emiliano, AB, Cruz, T, Pannoni, V, Fudge JL.  Interaction between serotonin transporter labeled fibers and oxytocin-positive cells in the primate hypothalamus: a substrate for SSRIs therapeutic effects?  Neuropsychopharmacology, available on-line Oct, 2006 (in press).