http://www.urmc.rochester.edu/technology-transfer/ Latest technology updates from the University of Rochester en-us Copyright 2013, University of Rochester http://www.urmc.rochester.edu/technology-transfer/ Thu, 23 May 2013 14:10:46 EST http://www.urmc.rochester.edu/technology-transfer/find-technologies/index.cfm?TechnolID=25735 Applications: This invention provides devices and methods for the combined use of light activated gene transduction (LAGT) employing ultraviolet light recombinant adeno-associated virus (r-AAV) for the purpose of introducing a desired gene into a patient’s tissue. This invention consists of multiple embodiments that deploy various strategic methods; each method is executed to most effectively deliver the light source to the target cells. The immediate application of this technology is gene therapy for cartilage injuries. Advantages: Attempts have been made to induce r-AAV transduction in vitro using UV radiation with a wavelength of 254 nm. However, no effective therapeutic method or apparatus was developed based on these experiments because the use of this wavelength presented a number of problems. This invention overcomes the long exposure time and safety issues associated with gama irradiation. 2013-05-21 00:00:00.0