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Prognostic Indicator of HIV/AIDS: CEM15 mRNA Levels
Present invention provides a method of measuring a novel prognostic marker for AIDS progression, and predicting whether a viral infected patient will be a nonprogressor. This invention also provides a method of predicting the level of CD4 cells in a patient, as well as a method of optimizing antiviral therapy in a viral infected patient.
A small subset of the AIDS patients categorized as long term nonprogressors (LTNPs) have a much slower disease progression rate. Several mechanisms have been suggested for LTNPs. However, no common factor has been identified to correlates LTNPs. The present invention provides a method of measuring one novel marker to predict AIDS progression in a patient and predict whether the patient will be LTNP. This invention also provides insights into novel therapeutic targets discovery for AIDS treatment. This invention has significant implications on new development of diagnostic tools and therapeutic targets to treat viral infections.
Intellectual Property Status:
Harold Smith, Ph.D. (website)
Xia Jin, M.D., Ph.D.
Andrew Brooks, Ph.D.
For Additional Information or for Licensing Opportunities:
Office of Technology Transfer
AIDS, Diagnostic, HIV, RNA
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