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URMC  » Gene Targeting & Transgenic Core

• Services & Priorities
• Instrumentation
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Welcome to the Gene Targeting and Transgenic Core

Currently, the Gene Targeting and Transgenic Core's services include the production of mouse models using DNA microinjection and embryonic stem cell injection (from gene targeting in mouse ES cells to production of chimeric mice) methodologies. Additional services have included: various analytical techniques, embryo cryopreservation, rederivation of pathogen-free rodents, and assisted reproduction techniques (e.g., in vitro fertilization [IVF], superovulation, and embryo transfer). Specific strains, and alternative species and methods are considered when appropriate for individual research applications.

Our Mission

The mission of the Gene Targeting and Transgenic Core is to provide expertise and assistance in the development and production of genetically engineered animal models of human disease, in a timely and cost-effective manner.

Faculty User Group

The following faculty members have been invited to serve on a faculty user group for this Core:

• Rulang Jiang
• Joe Miano
• Hucky Land
• Andrea Bottaro
• Kerry O'Banion