Thoracic and Head and Neck Pathology
The Thoracic Pathology subspecialty examines biopsy and surgical resection specimens of the lung, pleura and mediastinum.
We have expertise in the diagnosis of lung cancer, non-neoplastic interstitial lung disease, malignant mesothelioma and thymoma. We combine morphologic evaluation with immunohistochemistry and molecular testing to accurately diagnose and classify adenocarcinoma, squamous cell carcinoma, small cell carcinoma and other tumors of the lung, even in the small biopsy specimen.
Further gene mutation analyses, for example, for EGFR in lung cancer, particularly adenocarcinoma, can be performed in our Molecular Pathology lab to select patients for targeted and personalized therapy. We also specialize in the diagnosis of usual interstitial pneumonia (UIP), non-specific interstitial pneumonia (NSIP), desquamative interstitial pneumonia (DIP) and other types of non-neoplastic lung disorders.
We work closely with our multidisciplinary thoracic oncology team including surgeons, pulmonologists and oncologists at the URMC and discuss our findings in the tumor board and pulmonary medicine-pathology correlation conference for accurate diagnosis and effective patient management.
Head and Neck Pathology
The Head and Neck Pathology subspecialty service is included in the Thoracic Pathology service.
We are dedicated to diagnostic excellence and to improving clinical care while exploring new and superior methodologies. We utilize immunohistochemical staining, in-situ hybridization and gene mutation analysis, such as Human Papilloma Virus (HPV) typing, Epidermal Growth Factor Receptor (EGFR) presence and BRAF mutation analysis.
Along with our clinical and surgical colleagues, we are involved in HPV related squamous cell carcinoma of the head and neck and the impact of BRAF positive papillary thyroid carcinomas. Multidisciplinary tumor boards and clinical-pathologic correlation conferences tie together medical, surgical and pathologic expertise to discuss management plans for patients and provide the intercommunication necessary for successful patient care.
The surgical pathologists in the Thoracic Pathology subspecialty are interested in developing diagnostic and prognostic biomarkers in thoracic malignancy. We have identified several biomarkers which are significantly useful in diagnostic lung pathology. These findings have been published in peer-reviewed journals and validated by other investigators.
For more information or to request our services, please call (585) 275-3191.