Saturday September 26, 1998 - Question 1

Which of the following statements about the pharmacokinetics of gamma-hydroxybuyrate (GHB) is correct?

A. Gastrointestinal absorption of GHB is slow and sometimes delayed up to 6 hours.
 
B. GHB has a large volume of distribution and is well distributed to tissue.
 
C. GHB is rapidly metabolized through the tricarboxylic acid cycle to succinic acid and CO2 which is eliminated in expired air.
 
D. GHB has several active metabolites that are primarily responsible for the clinical manifestations of GHB toxicity.
 
E. Approximately 30% of GHB is eliminated unchanged in the urine.
 
 
 

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