Sunday October 11, 1998 - Question 2

Which of the following statements about the pharmacology/toxicology of calcium and the calcium channel blockers is correct?

A. In smooth muscle, calcium exerts its effect by combining  with calmodulin.

B. Activation of myosin results in decreased smooth muscle contraction and decreased peripheral vascular resistance.

C. Calcium channel blockers primarily affect the peripheral vasculature and have limited effect on the coronary vasculature.

D. Calcium also participates in the gradual depolarizing upstroke during phase two of the action potential.

E. Calcium primarily affects sinoatrial conductance and has limited effect on atrioventricular conductance.
 
 

Discussion