Tuesday October 13, 1998 - Question 4

Which of the following statements about the pharmacology/toxicology of the calcium channel blockers is correct?

A. Calcium channel blockers do not affect myocardial utilization of carbohydrates.

B. Calcium channel blockers have no known effect on insulin release from pancreatic islet cells.

C. Calcium channel blockers are not known to cause myocardial and peripheral insulin resistance.

D. Decreases in cardiac output secondary to calcium channel blocker toxicity are not known to affect insulin and substrate delivery.

E. Mitochondrial pyruvate dehydrogenase inhibition may contribute to the acidosis observed in calcium channel blocker toxicity.
 
 

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