Thursday September 3, 1998 - Question 6

Which of the following is correct regarding fomepizole pharmacokinetics?

A. Fomepizole does not affect ethanol clearance.
 
B. Fomepizole has been shown to induce its own metabolism after several doses.
 
C. The primary metabolite, 4-carboxypyrazole, has pharmacologic activity.
 
D. Fomepizole has a large volume of distribution of approximately 5 L/kg.
 
E. Ethanol does not affect fomepizole clearance.
 
 
 

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