Saturday September 5, 1998 - Question 8

Which of the following statements regarding fomepizole dosage is correct?

A. Fomepizole therapy can be initiated with the first maintenance dose.  Loading doses are not required.
 
B. A loading dose of 50 mg/kg is recommended.
 
C. The maintenance dose regimen is 10 mg/kg every 12 hours for 4 doses followed by 5 mg/kg every 12 hours.
 
D. Fomepizole therapy can be discontinued when the ethylene glycol concentration decreases below 10 mg/dL.
 
E. Since fomepizole is thought to induce its own metabolism after several doses, the dose should be increased to 15 mg/kg after the first four maintenance doses have been completed.
 
 

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