ELECTRONIC CONTINUING EDUCATION FOR
SPECIALISTS IN POISON INFORMATION
Module IX - A Review of Serotonin Syndrome and Neuroleptic Malignant Syndrome
INTRODUCTION
Welcome to Module 9 of the American Association of Poison Control Center’s electronic
continuing education program for Specialists in Poison Information. This module will review the pathophysiology,
clinical manifestations, monitoring, and management of serotonin syndrome and neuroleptic malignant syndrome.
release date - 11/20/98
most recent review date - 11/20/98
LEARNING OBJECTIVES
Upon completion of this module, participants will:
1. Understand the pathophysiology for each syndrome.
2. Recognize the clinical manifestations for each syndrome.
3. Understand the monitoring parameters for each syndrome.
4. Understand the management strategies for each syndrome.
AUTHOR
Peter Ciancaglini, PharmD
AUTHOR DECLARATIONS
NO DISCLOSURES have been made by the author(s) of this module that could be perceived
as a real or apparent conflict of interest in the context of the subject of their presentation(s).
REVIEW PANEL
Daniel Cobaugh, PharmD
Prashant Joshi, MD
Ruth Lawrence, MD
Thomas Martin, MD
Christine Stork, PharmD
Paul Wax, MD
REFERENCES
1. Martin TG. Serotonin syndrome. Annals of Emergency Medicine. 1996; 28:520-526.
2. Mills KC. Serotonin syndrome. American Family Physician. 1995; 52(5): 1475-1482.
3. Bertorini, TE. Myoglobinuria, malignant hyperthermia, neuroleptic malignant syndrome and
serotonin syndrome. Neurologic Clinics. 1997; 15(3): 649-671.
4. Balzan MV. The neuroleptic malignant syndrome: a logical approach to the patient with
temperature and rigidity. Postgraduate Medicine Journal. 1998; 74:72-76.
5. Guze BH, Baxter LR. Neuroleptic malignant syndrome. Medical Intelligence. 1985;
313(3): 163-166.
CERTIFICATION
The University of Rochester School of Medicine and Dentistry is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians.
The University of Rochester School of Medicine and Dentistry designates this educational activity for a maximum of 3.0 hours in Category 1 credit towards the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the educational activity.
This CME activity was planned and produced in accordance with the Essentials
and Standards of the Accreditation Council for Continuing Medical Education.