| Table 1. CYP3A4 Substrates | |||
| Alfentanil | Cyclobenzaprine | Ketoconazole | Sertraline |
| Alprazolam | Cyclophosphamide | Lansoprazole (minor) | Tacrolimus |
| Amitriptyline (minor) | Cyclosporine | Losartan | Tamoxifen |
| Amlodipine | Dapsone | Lovastatin | Temazepam |
| Astemizole | Dexamethasone | Mibefradil | Terfenadine |
| Atorvastatin | Dextromethorphan | Miconazole | Testosterone |
| Busulfan | Etoposide | Paclitaxel | Triazolam |
| Cannabinoids | Felodipine | Pravastatin | Verapamil |
| Carbamazepine | Fentanyl | Prednisone | Vinblastine |
| Cisapride | Fexofenadine | Quinidine | Vincristine |
| Clindamycin | Ifosamide | Quinine | R-warfarin |
| Clomipramine | Imipramine | Ritonavir | Zileuton |
| Clonazepam | Indinavir | Rifampin | |
| Cocaine | Isradipine | Saquinavir | |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.
Warfarin exists as two isomers, R-warfarin and D-warfarin. R-warfarin is
less pharmacologically active than S-warfarin. Significant interactions
have resulted from changes in the metabolism of either isomer.
| Table 2. CYP3A4 Inducers | |
| Carbamazepine | Primidone |
| Dexamethasone | Rifabutin |
| Ethosuximide | Rifampin |
| Phenobarbital | Troglitazone |
| Phenytoin | |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.
| Table 3. CYP3A4 Inhibitors | |
| Amiodarone | Mibefradil |
| Cannabinoids | Miconazole |
| Clarithromycin | Nefazodone |
| Erythromycin | Nelfinavir |
| Fluconazole | Norfloxacin |
| Fluoxetine | Omeprazole (slight) |
| Fluvoxamine | Quinine |
| Grapefruit juice | Ritonavir |
| Indinavir | Saquinavir |
| Itraconazole | Sertraline? |
| Ketoconazole | Troleandomycin |
| Metronidazole | Zafirlukast |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.
| Table 4. CYP2D6 Substrates | |||
| Amitriptyline | Donepezil | Meperidine | Propafenone |
| Bisoprolol | Doxepin | Methadone | Propranolol |
| Chlorpromazine | Flecainide | Methamphetamine | Risperidone |
| Clomipramine | Fenfluramine | Metoprolol | Thioridazine |
| Clozapine | Fluphenazine | Mexiletine | Timolol |
| Codeine | Fluoxetine | Morphine | Tramadol |
| Cyclobenzaprine | Haloperidol | Nortriptyline | Trazodone |
| Desipramine | Hydrocodone | Oxycodone | Venlafaxine |
| Dexfenfluramine | Imipramine | Paroxetine | |
| Dextromethorphan | Maprotiline | Perphenazine | |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.
| Table 5. CYP2D6 Inducers | |
| Carbamazepine | Rifampin |
| Phenobarbital | Ritonavir |
| Phenytoin | |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.
| Table 6. CYP2D6 Inhibitors | |
| Amiodarone | Mibefradil |
| Cimetidine | Paroxetine |
| Clomipramine | Propafenone |
| Desipramine | Quinidine |
| Fluoxetine | Ritonavir |
| Fluphenazine | Sertraline |
| Haloperidol | Thioridazine |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.
| Table 7. CYP1A2 Substrates | ||
| Amitriptyline | Desipramine | Theophylline |
| Caffeine | Diazepam | R-warfarin |
| Clomipramine | Haloperidol | Zileuton |
| Clozapine | Imipramine | |
| Cyclobenzaprine | Tacrine | |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.
| Table 8. CYP1A2 Inducers | |
| Phenobarbital | Ritonavir |
| Phenytoin | Smoking / PAH |
| Rifampin | |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.
| Table 9. CYP1A2 Inhibitors | |
| Cimetidine | Isoniazid |
| Ciprofloxacin | Ketoconazole |
| Clarithromycin | Levofloxacin |
| Enoxacin | Norfloxacin |
| Erythromycin | Omeprazole? |
| Fluvoxamine (potent) | Paroxetine |
| Grapefruit juice | |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.
| Table 10. CYP2C Substrates | |
| Amitriptyline | Omeprazole |
| Clomipramine | Phenytoin (2C9) |
| Diazepam | Topiramate (2C19) |
| Imipramine | Tolbutamide |
| Losartan (2C9) | S-warfarin(2C9) |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.
| Table 11. CYP2C Inducers |
| Carbamazepine |
| Phenobarbital |
| Phenytoin |
| Rifampin |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.
| Table 12. CYP2C Inhibitors | |
| Amiodarone (2C9) | Isoniazid |
| Chloramphenicol (2C9) | Ketoconazole (weak) |
| Cimetidine (2C9) | Omeprazole (2C9, 2C19) |
| Fluconazole | Sertraline |
| Fluoxetine | Topiramate (2C19) |
| Fluvastatin | Zafirlukast (2C9) |
| Fluvoxamine (2C9) | |
Adapted From: Michalets EL. Pharmacotherapy 1998;18(1):84-112.