Michael Kerry O'Banion, M.D., Ph.D.

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RECENT PUBLICATIONS:

Moore, A. H., J. A. Olschowka, Williams, J. P., Okunieff, P., and M. K. O'Banion. 2005. Regulation of prostaglandin E2 synthesis after brain irradiation. Int. J. Rad. Oncol. Biol. Phys. 62:267-272.

Heneka, M. T., M. Sastre, L. Dumitrescu-Ozimek, A. Hanke, I. Dewachter, C. Kuiperi, K. O'Banion, T. Klockgether, F. Van Leuven, and G. E. Landreth. 2005. Acute treatment with the PPAR? agonist pioglitazone and ibuprofen reduces glial inflammation and A?1-42 levels in APPV717I transgenic mice. Brain 128:1442-1453.

Hoozemans, J. J. M. and M. K. O'Banion. 2005. The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potential of nonsteroidal anti-inflammatory drugs. Curr. Drug Targets CNS and Neurol Disord. 4:307-315.

Joseph, S. A., E. Lynd-Balta, M. K. O'Banion, R. M. Rappold, J. Daeschner, A. Allen, and J. Padowski. 2006. Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures. Neuroscience 140:1051-1065.

Lai, Y.-C., S. S. Shaftel, J. H. Miller, R. H. Tallents, Y. Chang, C. A. Pinkert, J. A. Olschowka, I. M. Dickerson, J. E. Puzas, M. K. O'Banion, and S. Kyrkanides. 2006. Intra-articular induction of IL-1? expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction and pain. Arthritis and Rheumatism 54:1184-1197.

Maida, M. E., S. D. Hurley, J. Daeschner, A. H. Moore, and M. K. O'Banion. 2006. Cytosolic prostaglandin E2 synthase (cPGES) expression is decreased in discrete cortical regions in psychiatric disease. Brain Res. 1103:164-172.

Kyrkanides, S., P. M. Fiorentino, Y. Gan, Y-C. Lai, S. S. Shaftel, J. E. Puzas, M. G. Piancino, M. K. O'Banion, and R. H. Tallents. 2007. µ-opiod receptor induction in the temporomandibular joint ameliorates arthritic pain and joint pathology in the Col1-IL-1?XAT mouse model of arthritis. Arthritis and Rheumatism, 56:2038-2048.

Shaftel, S. S., S. Kyrkanides, J. A. Olschowka, J. H. Miller, R. E. Johnson, and M. K. O'Banion. 2007. Sustained hippocampal IL-1? overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J. Clin. Invest. 117:1595-1604.

Brouxhon, S, S. Kyrkanides, M. K. O'Banion, R. Johnson, D. A. Pearce, G. M. Centola, J. N. Miller, K. H. McGrath, B. Erdle, G. Scott, S. Schneider, J. vanBuskirk, and A. P. Pentland. 2007. Sequential downregulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent mechanism. Cancer Res. 67:7654-7664.

Shaftel, S. S., T. J. Carlson, J. A. Olschowka, S. Kyrkanides, S. B. Matousek, and M. K. O'Banion. 2007. Chronic IL-1? expression in mouse brain leads to leukocyte infiltration and neutrophil independent blood-brain barrier permeability without overt neurodegeneration. J. Neuroscience 27:9301-9309.

Heneka, M. T. and M. K. O'Banion. 2007. Inflammatory processes in Alzheimer's disease. J. Neuroimmunology, 184:69-91.

Zhong, Z., R. Deane, Z. Ali, M. Parisi, Y. Shapovalov, M. K. O'Banion, K. Stojanovic, A. Sagare, S. Boillee, D. W. Cleveland, and B. V. Zlokovic. 2008. ALS-causing SOD-1 mutants generate vascular changes prior to motor neuron degeneration. Nat. Neurosci. 11:420-422.

Shaftel, S. S., W. S. T. Griffin, and M. K. O'Banion. 2008. The role of interleukin-1 in neuroinflammation and Alzheimer's disease: an evolving perspective. J. Neuroinflammation. 5:7. Note: qualifies as a "Highly Accessed" article on BioMed Central.

Current Appointments

• Associate Professor - Department of Neurobiology and Anatomy (SMD)

Education
PhD Microbiology	Univ of Illinois-Urbana	1987
MD Medicine	Univ of Illinois Coll Medicine	1987
BS Biology	Univ of Illinois-Urbana	1980

Post-Doctoral Training & Residency
Postdoctoral Fellow, Departments of Medicine and Biochemistry, University of Rochester School of Medicine. Trained with Dr. D. A. Young.	1987 - 1990

Fellowship Awards
New York State Health Research Council Postdoctoral Fellowship for Diabetes Research.	1990 - 1991
Wilmot Cancer Research Postdoctoral Fellowship, University of Rochester.	1988 - 1991
NIH Postdoctoral Training Fellow in Endocrinology and Metabolism, University of Rochester.	1987 - 1989
University of Illinois College of Medicine Predoctoral Fellowship.	1986
University of Illinois Life Sciences Predoctoral Fellowship	1980

Recent Journal Articles
Showing the 5 most recent journal articles. (55 available)
Zhong Z; Deane R; Ali Z; Parisi M; Shapovalov Y; O'Banion MK; Stojanovic K; Sagare A; Boillee S; Cleveland DW; Zlokovic BV. "ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration." Nature neuroscience. 2008; 11(4):420-2. Epub 2008 Mar 16.
Kyrkanides S; Miller AW; Miller JN; Tallents RH; Brouxhon SM; Olschowka ME; O'Banion MK; Olschowka JA. "Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration." Journal of neuroimmunology. 2008; 203(1):50-7.
Fiorentino PM; Tallents RH; Miller JN; Brouxhon SM; O'Banion MK; Puzas JE; Kyrkanides S. "Spinal interleukin-1beta in a mouse model of arthritis and joint pain." Arthritis and rheumatism. 2008; 58(10):3100-9.
Kyrkanides S; Fiorentino PM; Miller JN; Gan Y; Lai YC; Shaftel SS; Puzas JE; Piancino MG; O'Banion MK; Tallents RH. "Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint." Arthritis and rheumatism. 2007; 56(6):2038-48.
Shaftel SS; Kyrkanides S; Olschowka JA; Miller JN; Johnson RE; O'Banion MK. "Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology." The Journal of clinical investigation. 2007; 117(6):1595-604.