Fred Sherman, Ph.D.

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Dr. Sherman has been investigating various broad aspects of gene expression in yeast, as means to determine processes operating in eukaryotic cells. By using iso-1-cytochrome c as a model system, general principles have been uncovered, including those involved in transcription, translation, co-translational and post-translational modification, mitochondrial import, heme attachment, enzymatic functions and protein degradation. Currently, efforts have been directed toward understanding the relationships between protein structure, protein modifications and degradation in vivo, and in uncovering new degradation systems in mitochondria.

Current Appointments

• Professor Emeritus - Department of Biochemistry and Biophysics (SMD)

Education
PhD Biophysics	Univ of Cal Berkeley	1958
BA Chemistry	Univ Minnesota-Twin City Cmp	1954

Recent Journal Articles
Showing the 5 most recent journal articles. (239 available)
Polevoda, B.; Hoskins, J.; Sherman, F.;. "Properties of Nat4, an N{alpha}-Acetyltransferase of Saccharomyces cerevisae that Modifies N termini of Histones H2A and H4". Mol Cell Biol (2009).
Kabir, M. A.; Sherman, F.;. "Overexpressed ribosomal proteins suppress defective chaperonins in Saccharomyces cerevisiae". FEMS Yeast Res 8 (2008): 1236-44.
Polevoda, B.; Brown, S.; Cardillo, T. S.; Rigby, S.; Sherman, F.;. "Yeast N(alpha)-terminal acetyltransferases are associated with ribosomes". J Cell Biochem (2007).
Polevoda, B.; Sherman, F.;. "Methylation of proteins involved in translation". Mol Microbiol 65 (2007): 590-606.
Polevoda B; Span L; Sherman F. "The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p." The Journal of biological chemistry. 2006; 281(5):2562-71. Epub 2005 Dec 01.