Leon L. Miller, M.D., Ph.D.

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Hormonal regulation of plasma protein synthesis in isolated perfused liver.

The isolated rat liver, perfused for 12 or 24 hours, has been used as a closed metabolic system for evaluating the regulatory effects of hormones and metabolic inhibitors in the net biosynthesis of specific plasma proteins with emphasis on the acute phase proteins. Current studies are seeking to define the production of Interlukin-6 and its interactions with glucocorticoids in the isolated perfused liver system.

Current Appointments

• Professor Emeritus - Department of Biochemistry and Biophysics (SMD)
• Professor Emeritus - Department of Medicine (SMD)

Education
MD Medicine	Univ Rochester Sch Med/Dent	1945
PhD Organic Chemistry	Cornell University	1937
BA Chemistry	Cornell University	1934

Recent Journal Articles
Showing the 5 most recent journal articles. (130 available)
Miller LL. "George Hoyt Whipple - August 28, 1878-February 2, 1976." Biographical memoirs. National Academy of Sciences (U.S.). 1995; 66():371-93.
Miller, L.L.; Treat, D.E.; Fridd, B.; Wemett, D.;. "Effects of streptozotocin diabetes in the rat on blood levels of ten specific plasma proteins and on their net biosynthesis by the isolated perfused liver". Hepatology 11 (1990): 635-45.
Miller LL; Treat DE; Fridd B; Wemett D. "Effects of streptozotocin diabetes in the rat on blood levels of ten specific plasma proteins and on their net biosynthesis by the isolated perfused liver." Hepatology (Baltimore, Md.). 1990; 11(4):635-45.
Sparks, J.D.; Sparks, C.E.; Miller, L.L.;. "Insulin effects on apolipoprotein B production by normal, diabetic and treated-diabetic rat liver and cultured rat hepatocytes". Biochem J. 261 (1989): 83-8.
Sparks JD; Sparks CE; Miller LL. "Insulin effects on apolipoprotein B production by normal, diabetic and treated-diabetic rat liver and cultured rat hepatocytes." The Biochemical journal. 1989; 261(1):83-8.