John A. Olschowka, Ph.D.
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Current Appointments
- Associate Professor - Department of Neurobiology and Anatomy (SMD)
| Journal Articles |
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| Showing 63 journal articles currently available. |
| Kyrakanides S, Miller AW, Miller JN, Tallents RH, Brouxhon SM, Olschowka ME, O'Banion MK, Olschowka JA. "Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration." J Neuroimmunol. 203 (2008): 50-57. |
| Shaftel SS; Kyrkanides S; Olschowka JA; Miller JN; Johnson RE; O'Banion MK. "Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology." The Journal of clinical investigation. 2007; 117(6):1595-604. |
| Kyrkanides S; Miller JN; Tallents RH; Brouxhon SM; Centola GM; Olschowka JA. "Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotype." Journal of neuroimmunology. 2007; 188(1-2):39-47. Epub 2007 Jun 18. |
| Shaftel SS; Carlson TJ; Olschowka JA; Kyrkanides S; Matousek SB; O'Banion MK. "Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007; 27(35):9301-9. |
| Lioy, D.T.; Sheridan, P.A.; Hurley, S.D.; Walton, J.R.; Martin, A.M.; Olschowka, J.A.; Moynihan, J.A. "Acute morphine exposure potentiates the development of HSV-1-induced encephalitis." J. Neuroimmunology 172 (2006): 9-17. |
| Liu W; Ding I; Chen K; Olschowka J; Xu J; Hu D; Morrow GR; Okunieff P. "Interleukin 1beta (IL1B) signaling is a critical component of radiation-induced skin fibrosis." Radiation research. 2006; 165(2):181-91. |
| Lai YC; Shaftel SS; Miller JN; Tallents RH; Chang Y; Pinkert CA; Olschowka JA; Dickerson IM; Puzas JE; O'Banion MK; Kyrkanides S. "Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain." Arthritis and rheumatism. 2006; 54(4):1184-97. |
| Kyrkanides, S.K.; Miller, J.H.; Brouxhon, S.M.; Olschowka, J.A.; Federoff, H.J. "ß-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration." Molecular Brain Res. 133 (2005): 286-298. |
| Moore, A.H.; Olschowka, J.A.; Williams, J.P.; Okunieff, P.; OBanion, M.K. "Regulation of prostaglandin E2 synthesis after brain irradiation." Int. J. Radiation Oncology Biol. Phys. 62 (2005): 267-272. |
| Moore AH; Olschowka JA; Williams JP; Paige SL; O'Banion MK. "Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain." Radiation research. 2004; 161(2):153-60. |
| Moore AH; Olschowka JA; O'Banion MK. "Intraparenchymal administration of interleukin-1beta induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain." Journal of neuroimmunology. 2004; 148(1-2):32-40. |
| Shaftel, S.S.; Olschowka, J.A.; Hurley, S.D.; Moore, A.H.; O'Banion, M.K. "COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells." Molecular Brain Res. 119 (2003): 213-215. |
| Olschowka JA; Bowers WJ; Hurley SD; Mastrangelo MA; Federoff HJ. "Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS." Molecular therapy : the journal of the American Society of Gene Therapy. 2003; 7(2):218-27. |
| Bowers WJ; Olschowka JA; Federoff HJ. "Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy." Gene therapy. 2003; 10(11):941-5. |
| Hurley SD; O'Banion MK; Song DD; Arana FS; Olschowka JA; Haber SN. "Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys." Experimental neurology. 2003; 184(2):659-68. |
| Hurley SD; Olschowka JA; O'Banion MK. "Cyclooxygenase inhibition as a strategy to ameliorate brain injury." Journal of neurotrauma. 2002; 19(1):1-15. |
| Wang CX; Reece C; Wrathall JR; Shuaib A; Olschowka JA; Hao C. "Expression of tumor necrosis factor alpha and its mRNA in the spinal cord following a weight-drop injury." Neuroreport. 2002; 13(11):1391-3. |
| Kyrkanides S; Tallents RH; Macher DJ; Olschowka JA; Stevens SY. "Temporomandibular joint nociception: effects of capsaicin on substance P-like immunoreactivity in the rabbit brain stem." Journal of orofacial pain. 2002; 16(3):229-36. |
| Kyrkanides S; Moore AH; Olschowka JA; Daeschner JC; Williams JP; Hansen JT; Kerry O'Banion M. "Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury." Brain research. Molecular brain research. 2002; 104(2):159-69. |
| Matsuoka Y; Picciano M; Malester B; LaFrancois J; Zehr C; Daeschner JM; Olschowka JA; Fonseca MI; O'Banion MK; Tenner AJ; Lemere CA; Duff K. "Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease." Amer. J. Pathology. 158 (2001): 1345-54. |
| Kyrkanides S; O'Banion MK; Whiteley PE; Daeschner JC; Olschowka JA. "Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury." Journal of neuroimmunology. 2001; 119(2):269-77. |
| Park, K.; Olschowka, J.A.; Richardson, L.A.; Chang, E.B.; Melvin, J.E. "Expression of multiple Na+/H+ Exchanger Isoforms in Rat Parotid Acinar and Ductal Cells." J. General Physiology 276 (1999): G470-478. |
| Kyrkanides S; Olschowka JA; Williams JP; Hansen JT; O'Banion MK. "TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury." Journal of neuroimmunology. 1999; 95(1-2):95-106. |
| O'Banion MK; Olschowka JA. "Localization and distribution of cyclooxygenase-2 in brain tissue by immunohistochemistry." Methods in molecular biology (Clifton, N.J.). 1999; 120():55-66. |
| Blair, M.L.; Want, A.; Olschowka, J.A.. Piekut, D. "Role of paraventricular nucleus parvicellular neurons in the compensatory responses to graded hemorrhage." Amer. J. Physiol.-Regulatory, Integrative, and Comparative Physiol. 44 (1998): R278- R285. |
| Olschowka, J.A.; Kyrkanides, S.; Harvey, B.K.; OBanion, M.K.; Williams, J.P.; Rubin, P.; Hansen, J.T. "ICAM-1 induction in the mouse CNS following irradiation." Brain Behavior and Immunity 11 (1997): 273-285. |
| Kaplan, M.D.; Olschowka, J.A.; OBanion, M.K. "Cyclooxygenase-1 behaves as a delayed response gene in PC12 cells differentiated by nerve growth factor." J. Biological Chemistry 272 (1997): 18534-18537. |
| Wang CX; Olschowka JA; Wrathall JR. "Increase of interleukin-1beta mRNA and protein in the spinal cord following experimental traumatic injury in the rat." Brain research. 1997; 759(2):190-6. |
| Blair ML; Piekut D; Want A; Olschowka JA. "Role of the hypothalamic paraventricular nucleus in cardiovascular regulation." Clinical and experimental pharmacology & physiology. 1996; 23(2):161-5. |
| Dopp JM; Breneman SM; Olschowka JA. "Expression of ICAM-1, VCAM-1, L-selectin, and leukosialin in the mouse central nervous system during the induction and remission stages of experimental allergic encephalomyelitis." Journal of neuroimmunology. 1994; 54(1-2):129-44. |
| Romano TA; Felten SY; Olschowka JA; Felten DL. "Noradrenergic and peptidergic innervation of lymphoid organs in the beluga, Delphinapterus leucas: an anatomical link between the nervous and immune systems." Journal of morphology. 1994; 221(3):243-59. |
| Sladek CD; Olschowka JA. "Dehydration induces Fos, but not increased vasopressin mRNA in the supraoptic nucleus of aged rats." Brain research. 1994; 652(2):207-15. |
| Earnest, D.J.; Olschowka, J.A. "Circadian regulation of immediate-early gene expression in the SCN pacemaker by light." J. Biological Rhythms 8 (1993): S65-S71. |
| Earnest DJ; DiGiorgio S; Olschowka JA. "Light induces expression of fos-related proteins within gastrin-releasing peptide neurons in the rat suprachiasmatic nucleus." Brain research. 1993; 627(2):205-9. |
| Romano TA; Felten SY; Olschowka JA; Felten DL. "A microscopic investigation of the lymphoid organs of the beluga, Delphinapterus leucas." Journal of morphology. 1993; 215(3):261-87. |
| Inglefield JR; Bitran D; Olschowka JA; Kellogg CK. "Selective effects on CRF neurons and catecholamine terminals in two stress-responsive regions of adult rat brain after prenatal exposure to diazepam." Brain research bulletin. 1993; 31(3-4):353-9. |
| Earnest DJ; Ouyang S; Olschowka JA. "Rhythmic expression of Fos-related proteins within the rat suprachiasmatic nucleus during constant retinal illumination." Neuroscience letters. 1992; 140(1):19-24. |
| Fitzsimmons MD; Olschowka JA; Wiegand SJ; Hoffman GE. "Interaction of opioid peptide-containing terminals with dopaminergic perikarya in the rat hypothalamus." Brain research. 1992; 581(1):10-8. |
| Higgins, G.A.; Olschowka, J.A. "IFN-g/LPS induction of IL-1beta gene expression in adult rat brain." Molecular Brain Research 4 (1991): 143-148. |
| Romano TA; Felten SY; Felten DL; Olschowka JA. "Neuropeptide-Y innervation of the rat spleen: another potential immunomodulatory neuropeptide." Brain, behavior, and immunity. 1991; 5(1):116-31. |
| Earnest DJ; Iadarola M; Yeh HH; Olschowka JA. "Photic regulation of c-fos expression in neural components governing the entrainment of circadian rhythms." Experimental neurology. 1990; 109(3):353-61. |
| Olschowka, J.A. "A simple embedding method for optimizing the thin sectioning of pre-embedded immunocytochemically stained tissue." J. Electron Microscopy Tech. 10 (1989): 373-374. |
| Date, I.; Felten, S.Y.; Olschowka, J.A.; Felten, D.L. "Limited recovery of striatal dopaminergic fibers by adrenal meduallary grafts in MPTP-treated aging mice." Experimental Neurology. 107 (1989): 197-207. |
| Yeh HH; Olschowka JA. "A system of corticotropin releasing factor-containing amacrine cells in the rat retina." Neuroscience. 1989; 33(1):229-40. |
| Felten, D.L.; Felten, S.Y.; Bellinger, D.L.; Carlson, S.L.; Ackerman, K.D.; Madden, K.S.; Olschowka, J.A.; Livnat, S. "Noradrenergic sympathetic neural interactions with the immune system: structure and function." Immunological Rev. 100 (1988): 225-260. |
| Felten SY; Felten DL; Bellinger DL; Carlson SL; Ackerman KD; Madden KS; Olschowka JA; Livnat S. "Noradrenergic sympathetic innervation of lymphoid organs." Progress in allergy. 1988; 43():14-36. |
| Silverman WF; Aravich PF; Collier TJ; Olschowka JA; Sladek JR. "Reinnervation of transplanted hypothalamic neurons by host aminergic fibers in rats." Brain research. 1987; 412(2):375-80. |
| Felten SY; Olschowka J. "Noradrenergic sympathetic innervation of the spleen: II. Tyrosine hydroxylase (TH)-positive nerve terminals form synapticlike contacts on lymphocytes in the splenic white pulp." Journal of neuroscience research. 1987; 18(1):37-48. |
| Felten, D.L.; Felten, S.Y.; Carlson, S.L.; Olschowka, J.A.; Livnat, S. "Noradrenergic and peptidergic innervation of lymphoid tissue." J. Immunology 135 (1985): 755s-765s. |
| Crawley JN; Olschowka JA; Diz DI; Jacobowitz DM. "Behavioral investigation of the coexistence of substance P, corticotropin releasing factor, and acetylcholinesterase in lateral dorsal tegmental neurons projecting to the medial frontal cortex of the rat." Peptides. 1985; 6(5):891-901. |
| Ebner FF; Olschowka JA; Jacobowitz DM. "The development of peptide-containing neurons within neocortical transplants in adult mice." Peptides. 1984; 5(1):103-13. |
| Hamill GS; Olschowka JA; Lenn NJ; Jacobowitz DM. "The subnuclear distribution of substance P, cholecystokinin, vasoactive intestinal peptide, somatostatin, leu-enkephalin, dopamine-beta-hydroxylase, and serotonin in the rat interpeduncular nucleus." The Journal of comparative neurology. 1984; 226(4):580-96. |
| Chronwall BM; Olschowka JA; O'Donohue TL. "Histochemical localization of FMRFamide-like immunoreactivity in the rat brain." Peptides. 1984; 5(3):569-84. |
| Olschowka, J.A.; O'Donohue, T.L.; Jacobowitz, D.M. "The coexistence and release of bovine pancreatic polypeptide-like immunoreactivity from noradrenergic superior cervical ganglia neurons." Peptides 4 (1983): 23l-238. |
| Kobayashi S; Olschowka JA; Jacobowitz DM. "Bovine pancreatic polypeptide-like immunoreactive nerves in the rat major cerebral arteries." Brain research bulletin. 1983; 10(3):373-6. |
| Kobayashi S; Kyoshima K; Olschowka JA; Jacobowitz DM. "Vasoactive intestinal polypeptide immunoreactive and cholinergic nerves in the whole mount preparation of the major cerebral arteries of the rat." Histochemistry. 1983; 79(3):377-81. |
| Jacobowitz, D.M.; Olschowka, J.A. "Coexistence of bovine pancreatic polypeptide-like immunoreactivity and catecholamine in neurons of the ventral aminergic pathway of the rat brain." Brain Res. Bull. 9 (1982): 39l-406. |
| Jacobowitz DM; Olschowka JA. "Bovine pancreatic polypeptide-like immunoreactivity in brain and peripheral nervous system: coexistence with catecholaminergic nerves." Peptides. 1982; 3(3):569-90. |
| Olschowka JA; O'Donohue TL; Mueller GP; Jacobowitz DM. "The distribution of corticotropin releasing factor-like immunoreactive neurons in rat brain." Peptides. 1982; 3(6):995-1015. |
| Olschowka, J.A.;Molliver, M.E.; Grzanna, R.; Rice, F.L.; Coyle, J.T. "The ultrastructural demonstration of noradrenergic synapses in the rat central nervous by dopamine-beta-hydroxylase immunocytochemistry." J. Histochem. Cytochem. 29 (1981): 27l-280. |
| Olschowka JA; O'Donohue TL; Jacobowitz DM. "The distribution of bovine pancreatic polypeptide-like immunoreactive neurons in rat brain." Peptides. 1981; 2(3):309-31. |
| Olschowka JA; Vijayan VK. "Postnatal development of cholinergic neurotransmitter enzymes in the mouse cerebellum. Biochemical, light microscopic and electron microscopic cytochemical investigations." The Journal of comparative neurology. 1980; 191(1):77-101. |
| Vijayan, V.K.; Olschowka, J.A. "Brain acetycholinesterase activity and multiplicity in the bonnet monkey (Macaca radiata) and the rhesus monkey (Macaca mulatta)." J. Neurochem. 28 (1977): ll4l-ll43. |
