Patricia J. Simpson-Haidaris, Ph.D.

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Journal Articles
Showing 46 journal articles currently available.
Duan HO; Simpson-Haidaris PJ. "Cell type-specific differential induction of the human gamma-fibrinogen promoter by interleukin-6." The Journal of biological chemistry. 2006; 281(18):12451-7. Epub 2006 Mar 08.
Lawrence SO, Simpson-Haidaris PJ. "Regulated de novo biosynthesis of fibrinogen in lung alveolar epithelial cells". (Thromb Haemost 92) Chosen as Journal Club Highlights. Clin Lab 50 (2004): 715-30.
Wells J; Gigliotti F; Simpson-Haidaris PJ; Haidaris CG. "Epitope mapping of a protective monoclonal antibody against Pneumocystis carinii with shared reactivity to Streptococcus pneumoniae surface antigen PspA." Infection and immunity. 2004; 72(3):1548-56.
Lawrence SO; Simpson-Haidaris PJ. "Regulated de novo biosynthesis of fibrinogen in extrahepatic epithelial cells in response to inflammation." Thrombosis and haemostasis. 2004; 92(2):234-43.
Sahni A; Sahni SK; Simpson-Haidaris PJ; Francis CW. "Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA, u-PAR, and PAI-1 in endothelial cells." Journal of thrombosis and haemostasis : JTH. 2004; 2(9):1629-36.
Duan HO; Simpson-Haidaris PJ. "Functional analysis of interleukin 6 response elements (IL-6REs) on the human gamma-fibrinogen promoter: binding of hepatic Stat3 correlates negatively with transactivation potential of type II IL-6REs." The Journal of biological chemistry. 2003; 278(42):41270-81. Epub 2003 Aug 04.
Rybarczyk BJ; Lawrence SO; Simpson-Haidaris PJ. "Matrix-fibrinogen enhances wound closure by increasing both cell proliferation and migration." Blood. 2003; 102(12):4035-43. Epub 2003 Aug 14.
Pereira M; Rybarczyk BJ; Odrljin TM; Hocking DC; Sottile J; Simpson-Haidaris PJ. "The incorporation of fibrinogen into extracellular matrix is dependent on active assembly of a fibronectin matrix." Journal of cell science. 2002; 115(Pt 3):609-17.
Odrljin,T. M.; Haidaris,C. G.; Lerner,N. B.; Simpson-Haidaris,P. J.;. "Integrin alphavbeta3-mediated endocytosis of immobilized fibrinogen by A549 lung alveolar epithelial cells". American Journal of Respiratory Cell and Molecular Biology : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association 24 (2001): 12-21.
Meh DA; Mosesson MW; Siebenlist KR; Simpson-Haidaris PJ; Brennan SO; DiOrio JP; Thompson K; Di Minno G. "Fibrinogen naples I (B beta A68T) nonsubstrate thrombin-binding capacities." Thrombosis research. 2001; 103(1):63-73.
Simpson-Haidaris PJ; Rybarczyk B. "Tumors and fibrinogen. The role of fibrinogen as an extracellular matrix protein." Annals of the New York Academy of Sciences. 2001; 936():406-25.
Pereira M; Simpson-Haidaris PJ. "Fibrinogen modulates gene expression in wounded fibroblasts." Annals of the New York Academy of Sciences. 2001; 936():438-43.
Nguyen,M. D.; Simpson-Haidaris,P. J.;. "Cell type-specific regulation of fibrinogen expression in lung epithelial cells by dexamethasone and interleukin-1beta". American Journal of Respiratory Cell and Molecular Biology : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association 22 (2000): 209-217.
Shi RJ; Simpson-Haidaris PJ; Marder VJ; Silverman DJ; Sporn LA. "Post-transcriptional regulation of endothelial cell plasminogen activator inhibitor-1 expression during R. rickettsii infection." Microbial pathogenesis. 2000; 28(3):127-33.
Lee LH; Gigliotti F; Wright TW; Simpson-Haidaris PJ; Weinberg GA; Haidaris CG. "Molecular characterization of KEX1, a kexin-like protease in mouse Pneumocystis carinii." Gene. 2000; 242(1-2):141-50.
Rybarczyk BJ; Simpson-Haidaris PJ. "Fibrinogen assembly, secretion, and deposition into extracellular matrix by MCF-7 human breast carcinoma cells." Cancer research. 2000; 60(7):2033-9.
Rybarczyk BJ; Pereira M; Simpson-Haidaris PJ. "Characterization of a monoclonal antibody, D73H, that maps to a highly conserved region on fibrinogen Bbeta chain." Thrombosis and haemostasis. 2000; 84(1):43-8.
Michelsen AE; Santi C; Holme R; Lord ST; Simpson-Haidaris PJ; Solum NO; Pedersen TM; Brosstad F. "The charge-heterogeneity of human fibrinogen as investigated by 2D electrophoresis." Thrombosis research. 2000; 100(6):529-35.
Shi RJ; Simpson-Haidaris PJ; Lerner NB; Marder VJ; Silverman DJ; Sporn LA. "Transcriptional regulation of endothelial cell tissue factor expression during Rickettsia rickettsii infection: involvement of the transcription factor NF-kappaB." Infection and immunity. 1998; 66(3):1070-5.
Haidaris CG; Fisher DJ; Gigliotti F; Simpson-Haidaris PJ. "Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells." Molecular biotechnology. 1998; 9(2):91-7.
Haidaris CG; Medzihradsky OF; Gigliotti F; Simpson-Haidaris PJ. "Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A." DNA research : an international journal for rapid publication of reports on genes and genomes. 1998; 5(2):77-85.
Simpson-Haidaris PJ; Courtney MA; Wright TW; Goss R; Harmsen A; Gigliotti F. "Induction of fibrinogen expression in the lung epithelium during Pneumocystis carinii pneumonia." Infection and immunity. 1998; 66(9):4431-9.
Guadiz G; Haidaris CG; Maine GN; Simpson-Haidaris PJ. "The carboxyl terminus of Pneumocystis carinii glycoprotein A encodes a functional glycosylphosphatidylinositol signal sequence." The Journal of biological chemistry. 1998; 273(40):26202-9.
Guadiz,G.; Sporn,L. A.; Goss,R. A.; Lawrence,S. O.; Marder,V. J.; Simpson-Haidaris,P. J.;. "Polarized secretion of fibrinogen by lung epithelial cells". American Journal of Respiratory Cell and Molecular Biology : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association 17 (1997): 60-69.
Guadiz G; Sporn LA; Simpson-Haidaris PJ. "Thrombin cleavage-independent deposition of fibrinogen in extracellular matrices." Blood. 1997; 90(7):2644-53.
Simpson-Haidaris PJ; Guadiz G. "Host response to inflammation elicited during Pneumocystis carinii pneumonia." The Journal of eukaryotic microbiology. 1997; 44(6):33S.
Shi RJ; Simpson-Haidaris PJ; Marder VJ; Silverman DJ; Sporn LA. "Increased expression of plasminogen activator inhibitor-1 in R. rickettsii-infected endothelial cells." Thrombosis and haemostasis. 1996; 75(4):600-6.
Odrljin TM; Shainoff JR; Lawrence SO; Simpson-Haidaris PJ. "Thrombin cleavage enhances exposure of a heparin binding domain in the N-terminus of the fibrin beta chain." Blood. 1996; 88(6):2050-61.
Odrljin TM; Rybarczyk BJ; Francis CW; Lawrence SO; Hamaguchi M; Simpson-Haidaris PJ. "Calcium modulates plasmin cleavage of the fibrinogen D fragment gamma chain N-terminus: mapping of monoclonal antibody J88B to a plasmin sensitive domain of the gamma chain." Biochimica et biophysica acta. 1996; 1298(1):69-77.
Odrljin TM; Francis CW; Sporn LA; Bunce LA; Marder VJ; Simpson-Haidaris PJ. "Heparin-binding domain of fibrin mediates its binding to endothelial cells." Arteriosclerosis, thrombosis, and vascular biology. 1996; 16(12):1544-51.
Wright TW; Gigliotti F; Haidaris CG; Simpson-Haidaris PJ. "Cloning and characterization of a conserved region of human and rhesus macaque Pneumocystis carinii gpA." Gene. 1995; 167(1-2):185-9.
Simpson-Haidaris PJ; Wright TW; Earnest BJ; Hui Z; Neroni LA; Courtney MA. "Cloning and characterization of a lung-specific cDNA corresponding to the gamma chain of hepatic fibrinogen." Gene. 1995; 167(1-2):273-8.
Harbol AW; Liesveld JL; Simpson-Haidaris PJ; Abboud CN. "Mechanisms of cytopenia in human immunodeficiency virus infection." Blood reviews. 1994; 8(4):241-51.
Courtney MA; Bunce LA; Neroni LA; Simpson-Haidaris PJ. "Cloning of the complete coding sequence of rat fibrinogen B beta chain cDNA: interspecies conservation of fibrin beta 15-42 primary structure." Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 1994; 5(4):487-96.
Thertulien R; Simpson-Haidaris PJ; Haidaris CG. "Intracellular localization of a Trypanosoma cruzi kDNA minicircle transcript using RNA: RNA in situ hybridization." The Journal of eukaryotic microbiology. 1994; 41(4):402-7.
Wright TW; Simpson-Haidaris PJ; Gigliotti F; Harmsen AG; Haidaris CG. "Conserved sequence homology of cysteine-rich regions in genes encoding glycoprotein A in Pneumocystis carinii derived from different host species." Infection and immunity. 1994; 62(5):1513-9.
Grøn B; Filion-Myklebust C; Bjørnsen S; Haidaris P; Brosstad F. "Cross-linked alpha s gamma t-chain hybrids in plasma clots studied by 1D- and 2D electrophoresis and western blotting." Thrombosis and haemostasis. 1993; 70(3):438-42.
Mayadas T; Wagner DD; Simpson PJ. "von Willebrand factor biosynthesis and partitioning between constitutive and regulated pathways of secretion after thrombin stimulation." Blood. 1989; 73(3):706-11.
Francis CW, Muller E, Henschen A, Simpson PJ, Marder VJ. "Carboxy-terminal amino acid sequences of two large variant forms of the human plasma fibrinogen g chain." Proc Natl Acad Sci, USA 85 (1988): 3358-3362.
Simpson PJ; Chou WG; Whitbeck AA; Young FE; Zain S. "Evidence for prokaryotic transcription and translation control regions in the human factor IX gene." Gene. 1987; 61(3):373-83.
Simpson PJ. "An improved method for mRNA isolation and characterization of in vitro translation products by Western blotting." Gene. 1987; 56(2-3):161-71.
Chan SY, Simpson PJ. "Size exclusion HPLC as a rapid monitor for mRNA isolation." Biotechniques 3 (1985): 114-117.
Sahni A, Simpson-Haidaris PJ, Sahni SK, Vaday GG, Francis CW. "Fibrinogen augments the effect of FGF-2 on prostate cancer cell growth." Submitted.
Pereira M, Sahni SK, Hansen SH, Simpson-Haidaris PJ. "Matrix remodeling by fibrinogen and wounding triggers sustained p38MAPK activation and induces IL-1b-mediated transcriptional upregulation of RhoE/Rnd3." Submitted.
Simpson-Haidaris PJ, *Lawrence SO, ¶Odrljin TM, Sahni A, Francis CW. "Cell proliferation induced by fibrinogen matrix remodeling and wounding is dependent on endogenous FGF-2 signaling through FGF-receptor-1." Submitted.
Mosesson MW, I Hernandez I, Raife TJ, Medved L, Yakovlev S, Simpson-Haidaris PJ. "Plasma fibrinogen gamma prime chain content in the thrombotic microangiopathy syndrome." Submitted.