Harris Andrew Gelbard, M.D., Ph.D.

See information for Patients. Viewing information for Researchers.

Contact

University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box 645
Rochester, New York 14642

Office: 585 275-2971

Fax: 585 275-3683

Dr. Gelbards laboratory is investigating the molecular and electrophysiologic mechanisms of synaptic plasticity and "synaptic apoptosis" during acute and chronic inflammation induced by viral gene products and cellular metabolites secreted from glial cells during human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS). Additionally, Dr. Gelbard is the principal investigator of a National Institutes of Mental Health-funded program project with a translational focus to investigate promising new neuroprotective strategies for individuals with neurologic disease associated with HIV-1 infection.

Selected References

Perry S, Norman J, Litzburg A, Dewhurst S, Gelbard HA. HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. J. Immunol., 174(7):4333-4344, 2005.

Dou, H, Ellison, B, Bradley, J, Kasiyanov, A, Xiong, H, Maggirwar, SB, Dewhurst, S, Gelbard, HA, Gendelman HE. Neuroprotective activities of lithium in murine HIV-1 encephalitis. J Neurosci, 25(37):8375-85, 2005.

Bellizzi MJ, Lu S-M, Masliah E, and Gelbard HA. Physiologic synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor. J. Clin. Inv., 115(11):3185-3192, 2005.

Current Appointments

Education
MD Medicine Northwestern Univ Medical Sch 1983
PhD Pharmacology Northwestern Univ-Chicago Cmp 1983
BS Arts & Sciences Northwestern Univ-Chicago Cmp 1976
Post-Doctoral Training & Residency
Clinical Fellow in Neurology, The Children's Hospital, Boston, MA 1988 - 1990
Dana Foundation Fellow in Developmental Neuropharmacology, McLean Hospital, Belmont, MA and Massachusetts General Hospital. Post-doctoral advisors: Ross J. Baldessarini, MD and Martin H. Teicher, MD, PhD 1988 - 1990
Neurology Chief Resident, The Children's Hospital, Boston, MA Director: Charles F. Barlow, MD 1987 - 1988
Neurology Resident, Longwood Program of Child Neurology, Boston, MA - Director: Charles E. Barlow, MD 1985 - 1987
Resident, Children's Memorial Hospital, Northwestern University, Chicago, IL 1984 - 1985
Internship, Children's Memorial Hospital, Northwestern University, Chicago, IL 1983 - 1984
Fellowship Awards
University of Rochester Medical Center, Department of Neurobiology and Anatomy 1989 - 1990
Postdoctoral Fellowship, Dana Foundation, Massachusetts General Hospital, Department of Psychiatry 1988 - 1989
Predoctoral Fellowship Grant, NIMH NRSA 1F31 MH08438, Northwestern University Graduate School, Department of Pharmacology 1980 - 1981
Predoctoral Fellowship, NIH Training Grant, Northwestern University Graduate School, Department of Pharmacology 1977 - 1980
Board Certifications
Diplomat in Neurology with Special Qualification in Child Neurology, American Board of Psychiatry and Neurology, 1989, certificate # 705
Recent Journal Articles
Showing the 5 most recent journal articles. (78 available)
Norman, J.P.; Perry, S.W.; Bentley, K.; Trejo, M.; Volsky, D.J.; Dewhurst, S.; Masliah, E. and Gelbard, H.A. "HIV-1 Tat Activities Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization." (2008): in review.
Dewhurst, S.; Maggirwar, S.B.; Schifitto, G.; Gendelman, H.E. and Gelbard, H.A. "Glycogen synthase kinase 3 beta (GSK-3B) as a therapeutic target in NeuroAIDS. J. Neuroimmune Pharm. 2007, 2:93-96." J. Neuroimmune Pharm. 2 (2007): 93-96.
Lu, S-M. and Gelbard, H.A. "The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation." J. Neuroimmune Pharm. (2007).
Norman JP; Perry SW; Kasischke KA; Volsky DJ; Gelbard HA. "HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons." Journal of immunology (Baltimore, Md. : 1950). 2007; 178(2):869-76.
Sui Z; Sniderhan LF; Schifitto G; Phipps RP; Gelbard HA; Dewhurst S; Maggirwar SB. "Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia." Journal of immunology (Baltimore, Md. : 1950). 2007; 178(5):3226-36.