Gary David Paige, M.D., Ph.D.

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Research:

Multisensory Interaction and Adaptive Plasticity in Spatial Localization and Orientation.

The sensori-neural processes underlying our abilities to localize, track, and interact with a cluttered environment are crucial attributes of daily life, and are among the most fundamental tasks of the nervous system. The integration of multiple sensory inputs are required to guide spatial behaviors, ranging from mundane tasks such as reaching for objects to complex ones such as navigating to and from the workplace. These functions are also among the first (and often most subtle) to register problems after head trauma, neurological disease, and aging. The goal of our research is to understand how the brain integrates sensory inputs from the outside world (location and motion of visual and auditory targets) with those of the internal senses (vestibular and somatosensory depictions of orientation and motion of the body and its parts,) to achieve meaningful spatial perceptions and behaviors (eye, head and postural movements and reflexes). An equally important interest is how plastic neural mechanisms register errors and adaptively adjust performance in order to maintain proper spatial calibration across sensory modalities, or analogously, recover normal function after suffering pathologic loss. Finally, an important translational concern is how the neural degeneration of natural aging affects spatial behavior and plasticity.

Current experiments address two intriguing areas of interest. One is understanding how the brain utilizes auditory and visual information about target location and motion in order to maintain accurate and congruent spatial calibration across modalities, as assessed through different forms of orienting movements ("pointing"). These include visually-guided manual pointing by laser joystick, and more natural gaze (eye and head) pointing. Since gaze shifts activate vestibular reflexes (vestibulo-ocular and –collic reflexes: VOR and VCR) as well as somatosensory feedback from the neck, we are studying how the senses interact with each other and with volitional and reflex motor control. We are also investigating the important challenges of spatial memory when targets are transient, as occurs frequently in nature. Finally, we are interested in how spatial sensory modalities are plastically co-calibrated by cross-sensory experience--an essential feature normal spatial behavior over a lifetime.

A second focus is how vestibular inputs during both angular (from the semicircular canals) and linear (from the otoliths) head motion interact with each other, despite an intriguing limitation in the physics of the linear form (Einstein's "equivalency principle"). As biological linear accelerometers, the otolith organs cannot readily distinguish accelerations due to head tilt (relative to gravity) from those arising during translational (as opposed to angular) motion, and yet relevant behaviors and perceptions associated with these two forms of motion differ greatly. We are characterizing the compromised but fascinating solutions that have evolved to help resolve (albeit imperfectly) this sensory ambiguity.

Our research environment is unique in structure and instrumentation, as well as broad and translational in character. We benefit from a collegiate and multi-disciplinary group of faculty working on problems of common interest.

Current Appointments

• Chairman - Department of Neurobiology and Anatomy (SMD)
• Kilian J. and Caroline F. Schmitt Professorship in Neurobiology and Anatomy - Department of Neurobiology and Anatomy (SMD)
• Professor - Department of Neurobiology and Anatomy (SMD)
• Professor - Department of Center for Visual Science (RC)
• Professor - Department of Brain/Cognitive Sciences (RC)
• Professor - Department of Neurology (SMD)
• Professor - Department of Otolaryngology (SMD)
• Professor - Department of Biomedical Engineering (SMD)
• Professor - Department of Ophthalmology (SMD)

Education
MD Medicine	Univ Chicago Pritzker Sch Med	1981
PhD Neurophysiology	University of Chicago	1980
BS Biology	Univ of Cal Irvine	1974

Post-Doctoral Training & Residency
Resident University of California-san Francisco San Francisco, California 94143	1982 - 1985
Clinical Internship Dept. of Anesthesiology Michael Reese Hospital Chicago, Illinois	1981 - 1982

Lab Website

http://www.urmc.rochester.edu/labs/Paige-Lab/

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Recent Journal Articles
Showing the 5 most recent journal articles.
Cui QN; Bachus L; Knoth E; O'Neill WE; Paige GD. "Eye position and cross-sensory learning both contribute to prism adaptation of auditory space." Progress in brain research. 2008; 171():265-70.
Yong NA; Paige GD; Seidman SH. "Multiple sensory cues underlying the perception of translation and path." Journal of neurophysiology. 2007; 97(2):1100-13. Epub 2006 Nov 22.
Razavi B; O'Neill WE; Paige GD. "Auditory spatial perception dynamically realigns with changing eye position." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007; 27(38):10249-58.
Barnes GR; Paige GD. "Anticipatory VOR suppression induced by visual and nonvisual stimuli in humans." Journal of neurophysiology. 2004; 92(3):1501-11. Epub 2003 Dec 03.
Zwiers MP; Van Opstal AJ; Paige GD. "Plasticity in human sound localization induced by compressed spatial vision." Nature neuroscience. 2003; 6(2):175-81.