James Robert Campbell, M.D., M.P.H.

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Dr. Campbell's research focuses on childhood lead toxicity, with two major projects underway:

Lead exposure and bone development: Basic-science research and our own preliminary studies show that lead exposure can adversely affect the development of bone density. The current study, being conducted with the Department of Orthopedics, is investigating whether lead exposure is a risk factor for the development of osteoporosis. We are conducting cross-sectional studies on 8-9 year old children, 18-19 year-old adolescents and 60-65 year old adults. All subjects are having their bone density measured by DEXA, and their bone lead level measured by KXRF; the URMC is one of the few institutions in the country to have KXRF technology. This project is funded by the National Institute of Environmental Health Sciences of the NIH.

Lead exposure and humoral immunity: Basic-science research studies show that lead exposure can adversely affect the development of antibodies after an infection or immunization. The current study, being conducted with the Cancer Institute, is investigating whether lead exposure is associated with lowered humoral response after vaccination with the HPV vaccine. We will enroll 11-12 year old girls with a broad-range of past lead exposure based on blood lead levels obtained at ages 1-3 years. All will have blood drawn before the vaccine is administered and at 1, 2, and 6 months after the first vaccine. This project is funded by the National Institute of Environmental Health Sciences at NIH.

Specialty

General Pediatrics

Current Appointments

• Associate Professor - Department of Pediatrics (SMD)

Education
MPH Public Health	University of Rochester School of Medicine and Dentistry	1993
MD Medicine	Medical College Ohio	1985
BS Chemistry	University of Akron	1980

Post-Doctoral Training & Residency
General Pediatrics Academic Fellowship, Funded by Public Health Service, NIH, National Institute of Child Health and Human Development, University of Rochester School of Medicine and Dentistry, Rochester, NY	1988 - 1991
Residency in Pediatrics, Rainbow Babies and Children's Hospital, University Hospitals of Cleveland, Cleveland, OH	1985 - 1988
Pathology Student Fellowship, Department of Pathology, Medical College of Ohio, Toledo, OH	1982 - 1983

Board Certifications
American Board of Pediatrics	2004 - 2010

Recent Journal Articles
Showing the 5 most recent journal articles. (13 available)
Campbell JR, Rosier RN, Novotny L, Puzas JE. "The association between environmental lead exposure and bone density in children". Env Hlth Persp 112 (2004): 1200-1203.
Campbell JR, Toribara TY. "Hair-root lead to screen for lead toxicity". J Trace Elem Exp Med 14 (2001): 69-72.
Campbell J, Moss M, Raubertas R. "The association between caries and childhood lead exposure". Env Hlth Persp 108 (2000): 1099-1102.
Campbell JR, Schaffer SJ. "Predicting the outcome of the CaNa2EDTA challenge test in children with moderately elevated blood lead levels". Env Hlth Persp 107 (1999): 437-440.
Weitzman M, Campbell JR, Schaffer S. "Childhood lead poisoning and managed care". J Public Health Manage Pract 4 (1998): 73-81.