Regis James O'Keefe, M.D., Ph.D.

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Dr. O'Keefe is an orthopaedic oncologist, or a surgeon who focuses his practice on people with tumors of bone, joints, and soft tissue. He also cares for patients with fragility fractures from osteoporosis, osteopenia, osteogenesis imperfecta, and low vitamin D. Because many patients entering Dr. O'Keefe's practice are experiencing the most challenging time of their life, his treatment goal is to provide the best quality of life possible and instill confidence in his patients that they are getting the best care possible.

Dr. O'Keefe earned his medical degree from Harvard Medical School and completed a residency in orthopaedic surgery at URMC. He then completed the Massachusetts General Hospital fellowship in orthopaedic oncology. Soon, he realized he could help more people if the causes of diseases of the skeleton were better understood. He earned a PhD in biochemistry at URMC while conducting research.

Dr. O'Keefe, a national leader in the field of orthopaedics, is the Chair of URMC's Department of Orthopaedics and Rehabilitation. He also serves as the Director of the Center for Musculoskeletal Research at URMC, a team of nearly 70 physicians, biomedical scientists, and graduate and post-doctoral students. This team remains the top orthopaedics research lab in the United States since 2006.

Specialties

Bone Health, Osteoporosis, Oncology, Metabolic Bone Disease, and Geriatric Care

Current Appointments

• Chairman - Department of Orthopaedics (SMD)
• Director - Center for Musculoskeletal Research (SMD)
• Marjorie Strong Wehle Professor in Orthopaedics - Department of Orthopaedics (SMD)
• Professor - Department of Orthopaedics (SMD)
• Professor - Department of Pathology and Laboratory Medicine (SMD)
• Professor - Department of Environmental Medicine (SMD)

Board Certifications
Board Certification- Orthopaedics	Present

Education
PhD Biochemistry	University of Rochester School of Medicine and Dentistry	2000
MD Medicine	Harvard Medical School	1985
BA Philosophy	Yale University	1981

Post-Doctoral Training & Residency
Massachusetts General Hospital Fellowship in Orthopaedic Oncology	1992 - 1993
The University of Rochester Medical Center, Rochester, NY Resident in Orthopaedics	1988 - 1992
University of Rochester School of Medicine and Dentistry, Instructor and Fellow in Research Orthopaedic Research Laboratories	1986 - 1988
University of Rochester School of Medicine and Dentistry, Instructor and Fellow in Research, Endocrinology Training Grant	1986 - 1988
New England Deaconess Hospital Harvard Medical School Surgical Internship	1985 - 1986

Awards and Honors
Best Doctors in America for Cancerous Tumor Surgery	2009
Fifth Annual Dr. Marvin J Hoffman Award in the Area of Faculty Mentoring to Medical Students, Awarded at the Annual Hoffman Awards Ceremony,	2003
Dean's Endowed Chair, Professor of Orthopaedics and Oncology, University of Rochester School of Medicine.	2000
American Orthopaedic Association ABC Traveling Fellowship,	1999
Dean's Endowed Chair, Associate Professor of Orthopaedics, University of Rochester School of Medicine.	1998
The Dane and Mary Louise Miller Endowed Research Grant, Orthopaedic Research and Educational Foundation,	1997
Kappa Delta Award, Orthopaedic Research & Education Foundation.	1995
AOA Resident Traveling Research Award, "Differential expression of transforming growth factor-ß receptors and biological effects in maturationally distinct subpopulations of growth plate chondrocytes.	1988