Patricia Rose Chess, M.D.

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Contact

University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester, New York 14642

Office: 585 275-2972 (primary)

Fax: 585 461-3614

Portrait

Dr Chess' research is on lung injury and repair in the neonate, focusing on mechanical forces in the lung. Mechanisms of cellular signaling in response to mechanical strain and nanoparticles are being investigated, concentrating on p42/44 MAP Kinase and ROS signal transduction pathways involved in the stimulation of proliferation induced by mechanical strain in alveolar epithelial cells and related cell lines. In vitro studies are complemented by a ventilated murine model. Also being examined are surfactant dysfunction and the inflammatory response in aspiration and ventilator-induced lung injury, and the additional effects of oxygen on these injury models. A porcine model of acute lung injury is being used to optimize conditions of gene delivery of ENaC and Na K-ATPase subunits during acute lung injury or acute respiratory distress syndrome (ALI/ ARDS) followed by testing efficacy in treating established ALI-ARDS from surfactant depletion or sepsis. Clinical areas of focus include use of extracorporeal membrane oxygenation (ECMO) in neonatal respiratory failure, surfactant replacement therapy, and optimal modes of ventilation. (funded by NIH and NYSDOH)

Specialty

Neonatology

Current Appointments

Education
MD Medicine Columbia University College of Physicians and Surgeons 1988
AB Mathematics/Chemistry Colgate University 1983
Post-Doctoral Training & Residency
Neonatology Fellowship, Strong Memorial Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY 1991 - 1994
Chief Resident in Pediatric Outpatient Department, Strong Memorial Hospital, Rochester, NY 1991
Residency in Pediatrics, Strong Memorial Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY 1988 - 1991
Fellowship Awards
Source: NIH T32-HL-07216-18 Title: Multidisciplinary training program in pulmonary research Amount : $35,300 annual direct costs 1992 - 1995
Sponsor: Strong Memorial Hospital Innovations in Patient Care Title: Indications for screening head ultrasounds to detect intraventricular hemorrhage in premature infants Role: Principal Investigator Amount: $12,800 TDC 1992 - 1994
Board Certifications
American Board of Pediatrics, Neonatology 1995 - Present
American Board of Pediatrics 1991 - Present
Recent Journal Articles
Showing the 5 most recent journal articles. (47 available)
Schwab U; Rohde KH; Wang Z; Chess PR; Notter RH; Russell DG. "Transcriptional responses of mycobacterium tuberculosis to lung surfactant." Microbial Pathogenesis 46(4) (2009): 185-93.
Min Yee, M.; Chess, PR.; McGrath-Morrow, S.; Wang, Z.; Gelein, R.; Zhou, R.; Dean, D.; Notter, R.; O'Reilly, M. "Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity." Am J Physiol Lung Cell Mol Physiol 297 (2009): 641-649.
Raghavendran K; Pryhuber GS; Chess PR; Davidson BA; Knight PR; and Notter RH. "Pharmacotherapy of Acute Lung Injury and Acute Respiratory Distress Syndrome". Current Medicinal Chemistry 15 (2008): 1991-1924.
Wang Z; Schwab U; Rhoades E; Chess PR; Russell DG; Notter RH. "Peripheral cell wall lipids of Mycobacterium tuberculosis are inhibitory to surfactant function." Tuberculosis (Edinburgh, Scotland). 2008; 88(3):178-86. Epub 2007 Dec 21.
Raghavendran K; Davidson BA; Knight PR; Wang Z; Helinski J; Chess PR; Notter RH. "Surfactant dysfunction in lung contusion with and without superimposed gastric aspiration in a rat model." Shock (Augusta, Ga.). 2008; 30(5):508-17.