Edward M. Schwarz, Ph.D.

See information for Patients. Viewing information for Researchers.

Dr. Schwarz is Professor of Orthopaedics and Associate Director of the

Center for Musculoskeletal Research at URMC. His laboratory focuses on

finding solutions to bone loss due to conditions such as rheumatoid

arthritis, infections, tumors that spread to bone, and bone destruction near

the implants used in reconstructive surgery.

Several genes are known to turn on the healing process in bone. Dr.

Schwarz's group loads these genes into harmless virus particles. The

particles are coated onto experimental bone implants to deliver therapeutic

genes to the area of reconstruction, thus improving bone healing. The

cartilage that lines joints in mice can be encouraged to heal more

completely when virus particles deliver therapeutic genes too.

An additional interest of Dr. Schwarz's lab is the use of magnetic resonance

imaging (MRI) and high resolution computed tomography (CT) scans to

visualize the formation of new blood vessels as patients heal.

Current Appointments

• Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)
• Professor - Department of Biomedical Engineering (SMD)
• Professor - Department of Medicine (SMD)
• Professor - Department of Microbiology and Immunology (SMD)
• Professor - Department of Pathology and Laboratory Medicine (SMD)
• Professor - Department of Urology (SMD)

Education
PhD Immunology, All Other	Einstein College Medicine	1993
MA Immunology, All Other	Einstein College Medicine	1990
BS Biology	Worcester Polytech Inst	1988

Post-Doctoral Training & Residency
Laboratory of Inder M. Verma, Ph.D., Laboratory of Genetics The Salk Institute, La Jolla, California, Concentrations: Gene Therapy, NFkB Signal, Transduction, Transgenic Mice.	1993 - 1997
Training - Pre-doctoral Fellow, Laboratory of Barry R. Bloom, Ph.D., Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York	1988 - 1993
Training - Undergraduate Research Laboratory of Donald J. Tipper, Ph.D., Department of Microbiology & Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts	1987 - 1988
Training - Summer Student - Laboratory of Carl Shilkraut, Ph.D., Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York	1987
Training - Summer Student - Laboratory of Fritz Herz, Ph.D., Department of Pathology, Montefiore Medical Center, Bronx, New York	1986

Fellowship Awards
Postdoctoral Fellowships The Arthritis Foundation $76,500. Molecular Regulation of Lymphokine Profiles., Inder M. Verma, Mentor	1994 - 1997
The National Multiple Sclerosis Society $80,000. Molecular Regulation of Lymphokine Profiles., Inder M. Verma, Mentor	1994 - 1997

Lab Description

The Center for Musculoskeletal Research houses nearly 70 MD and PhD researchers and graduate and post-doctoral students. This team has been the top orthopaedics lab in the United States since 2006.

---

Lab Website

http://www.urmc.rochester.edu/ortho/research/index.cfm

---

Recent Journal Articles
Showing the 5 most recent journal articles. (104 available)
Eliseev,R. A.; Dong,Y. F.; Sampson,E.; Zuscik,M. J.; Schwarz,E. M.; O'Keefe,R. J.; Rosier,R. N.; Drissi,M. H.;. "Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis". Oncogene (2008).
Hasslund,S.; Jacobson,J. A.; Dadali,T.; Basile,P.; Ulrich-Vinther,M.; Soballe,K.; Schwarz,E. M.; O'Keefe,R. J.; Mitten,D. J.; Awad,H. A.;. "Adhesions in a murine flexor tendon graft model: Autograft versus allograft reconstruction". J.Orthop.Res. (2008).
Tsutsumi,R.; Hock,C.; Bechtold,C. D.; Proulx,S. T.; Bukata,S. V.; Ito,H.; A Awad,H.; Nakamura,T.; O'Keefe,R. J.; Schwarz,E. M.;. "Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT". J.Orthop.Res. (2008).
Kaback LA; Soung do Y; Naik A; Smith N; Schwarz EM; O'Keefe RJ; Drissi H. "Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification." Journal of cellular physiology. 2008; 214(1):173-82.
Li D; Gromov K; Søballe K; Puzas JE; O'Keefe RJ; Awad H; Drissi H; Schwarz EM. "Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity." Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2008; 26(1):96-105.