Joseph M. Miano, Ph.D.
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Current Appointments
- Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD)
- Associate Professor - Department of Pathology and Laboratory Medicine (SMD)
| Journal Articles |
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| Showing 61 journal articles currently available. |
| Bell, R.D.; Deane Chow, N.; Long, X.; Sagare, A.; Streb, J.W.; Guo, H.; Rubio, A.; Van Nostrand, W.; Miano, J.M.,; and, R, Zlokovic, B.V. "SRF and myocardin repress LRP-mediated amyloid-beta clearance in brain vascular smooth muscle cells via SREBP2." Nature Cell Biology 11 (2009): 143-153. |
| Lee TH; Chen J; Miano JM. "Functional characterization of a putative serine carboxypeptidase in vascular smooth muscle cells." Circulation research. 2009; 105(3):271-8. Epub 2009 Jul 02. |
| Cordes KR; Sheehy NT; White MP; Berry EC; Morton SU; Muth AN; Lee TH; Miano JM; Ivey KN; Srivastava D. "miR-145 and miR-143 regulate smooth muscle cell fate and plasticity." Nature. 2009; 460(7256):705-10. Epub 2009 Jul 05. |
| Sun Q; Taurin S; Sethakorn N; Long X; Imamura M; Wang DZ; Zimmer WE; Dulin NO; Miano JM. "Myocardin-dependent activation of the CArG box-rich smooth muscle gamma actin gene: Preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein." The Journal of biological chemistry. 2009; Epub 2009 Sep 28. |
| Long X; Tharp DL; Georger MA; Slivano OJ; Lee MY; Wamhoff BR; Bowles DK; Miano JM. "The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin." The Journal of biological chemistry. 2009; Epub 2009 Oct 01. |
| Long, X.; Bell, R.D.; Gerthoffer, W.T.; Zlokovic, B.V.; Miano, J.M. "Myocardin is sufficient for a smooth muscle cell-like contractile phenotype." Arteriosclerosis Thrombosis & Vascular Biology 28 (2008): 1505-1510. |
| Davis JL; Long X; Georger MA; Scott IC; Rich A; Miano JM. "Expression and comparative genomics of two serum response factor genes in zebrafish." The International journal of developmental biology. 2008; 52(4):389-96. |
| Long X.; Creemers, E.E.; Wang, D-Z.; Olson, E.N; Miano, J.M. "Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation." Proceedings of the National Academy of Sciences, USA 104 (2007): 16570-16575. |
| Chow, N.; Bell, R.D.; Deane R., Streb, J.W.; Guo, H.; Chen, J.; Rubio, A.; Brooks, A.; Van Nostrand, W.; Miano, J.M.; Zlokovic, B.V. "Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype." Proceedings of the National Academy of Sciences, USA 104 (2007): 823-828. |
| Miano JM; Long X; Fujiwara K. "Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus." American journal of physiology. Cell physiology. 2007; 292(1):C70-81. Epub 2006 Aug 23. |
| Long X; Miano JM. "Remote control of gene expression." The Journal of biological chemistry. 2007; 282(22):15941-5. Epub 2007 Apr 02. |
| Miano, J.M.; Georger, M.A.; Rich, A.; de Mesy Bentley, K.L. "Ultrastructure of zebrafish dorsal aortic cells." Zebrafish 3 3 (2006): 455-463. |
| Lee, T-H.D.; Streb, J.W.; Georger, M.A.; Miano, J.M. "Tissue expression of the novel serine carboxypeptidase Scpep1." Journal of Histochemistry & Cytochemistry 54 (2006): 701-711. |
| Sun Q; Chen G; Streb JW; Long X; Yang Y; Stoeckert CJ; Miano JM. "Defining the mammalian CArGome." Genome research. 2006; 16(2):197-207. Epub 2005 Dec 19. |
| Rensen SS; Niessen PM; Long X; Doevendans PA; Miano JM; van Eys GJ. "Contribution of serum response factor and myocardin to transcriptional regulation of smoothelins." Cardiovascular research. 2006; 70(1):136-45. Epub 2006 Jan 31. |
| Nagel DJ; Aizawa T; Jeon KI; Liu W; Mohan A; Wei H; Miano JM; Florio VA; Gao P; Korshunov VA; Berk BC; Yan C. "Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival." Circulation research. 2006; 98(6):777-84. Epub 2006 Mar 02. |
| Streb JW; Miano JM. "AKAP12alpha, an atypical serum response factor-dependent target gene." The Journal of biological chemistry. 2005; 280(6):4125-34. Epub 2004 Dec 07. |
| Zlokovic BV; Deane R; Sallstrom J; Chow N; Miano JM. "Neurovascular pathways and Alzheimer amyloid beta-peptide." Brain pathology (Zurich, Switzerland). 2005; 15(1):78-83. |
| Streb JW; Miano JM. "Cross-species sequence analysis reveals multiple charged residue-rich domains that regulate nuclear/cytoplasmic partitioning and membrane localization of a kinase anchoring protein 12 (SSeCKS/Gravin)." The Journal of biological chemistry. 2005; 280(30):28007-14. Epub 2005 May 27. |
| Qiu P; Ritchie RP; Fu Z; Cao D; Cumming J; Miano JM; Wang DZ; Li HJ; Li L. "Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo." Circulation research. 2005; 97(10):983-91. Epub 2005 Oct 13. |
| Miano, J.M.; Ramanan, N.; Georger, M.A.; de Mesy Bentley, K.L.; Emerson, R.L.; Balza, R.O., Jr.; Xiao, Q.; Weiler, H., Ginty, D.D.; Misra, R.P. "Restricted inactivation of serum response factor to the cardiovascular system." Proceedings of the National Academy of Sciences, USA 101 (2004): 17132-17137. |
| Jiang M; Mezentsev A; Kemp R; Byun K; Falck JR; Miano JM; Nasjletti A; Abraham NG; Laniado-Schwartzman M. "Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels." Circulation research. 2004; 94(2):167-74. Epub 2003 Dec 11. |
| Zhang R; Al-Lamki R; Bai L; Streb JW; Miano JM; Bradley J; Min W. "Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner." Circulation research. 2004; 94(11):1483-91. Epub 2004 Apr 29. |
| Hogarth DK; Sandbo N; Taurin S; Kolenko V; Miano JM; Dulin NO. "Dual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATP." American journal of physiology. Cell physiology. 2004; 287(2):C449-56. Epub 2004 Apr 14. |
| Streb JW; Kitchen CM; Gelman IH; Miano JM. "Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles." The Journal of biological chemistry. 2004; 279(53):56014-23. Epub 2004 Oct 20. |
| Miano, J.M. "Serum response factor: toggling between disparate programs of gene expression." Journal of Molecular & Cellular Cardiology 35 (2003): 577-593. |
| Davis, A.; Hogarth, K.; Fernandes, D.; Solway, J.; Niu, J.; Kolenko, V.; Luttrell, L.; Browning, D.; Miano, J.M.; Orlov, S.; Dulin, N.O. "Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA." Cell Signaling 15 (2003): 597-604. |
| Chen J; Chada S; Mhashilkar A; Miano JM. "Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration." Molecular therapy : the journal of the American Society of Gene Therapy. 2003; 8(2):220-9. |
| Aizawa T; Wei H; Miano JM; Abe J; Berk BC; Yan C. "Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells." Circulation research. 2003; 93(5):406-13. Epub 2003 Aug 14. |
| Chen, J.; Kitchen, C.M.; Streb, J.W.; Miano, J.M. "Myocardin: a component of a molecular switch for smooth muscle cell differentiation." Journal of Molecular & Cellular Cardiology 34 (2002): 1345-1356. |
| Miano, J.M.; Kitchen, C.M.; Chen, J.; Maltby, K.M.; Kelly, L.A.; Weiler, H.; Krahe, R.; Ashworth, L.K.; Garcia, E. "Human smooth muscle calponin expression in transgenic mice revealed with a bacterial artificial chromosome." American Journal of Physiology Heart & Circulatory Physiology 282 (2002): H1793-1803. |
| Chen, J.; Maltby, K.M.; Miano, J.M. "A novel retinoid-response gene set in vascular smooth muscle cells." Biochemical Biophysical Research Communication 281 (2001): 475-482. |
| Miano JM; Thomas S; Disteche CM. "Expression and chromosomal mapping of the mouse smooth muscle calponin gene." Mammalian genome : official journal of the International Mammalian Genome Society. 2001; 12(3):187-91. |
| Dulin NO; Orlov SN; Kitchen CM; Voyno-Yasenetskaya TA; Miano JM. "G-protein-coupled-receptor activation of the smooth muscle calponin gene." The Biochemical journal. 2001; 357(Pt 2):587-92. |
| Chen J; Streb JW; Maltby KM; Kitchen CM; Miano JM. "Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells." The Journal of biological chemistry. 2001; 276(36):34175-81. Epub 2001 Jul 10. |
| Frame MD; Miano JM; Yang J; Rivers RJ. "Localized adenovirus-mediated gene transfer into vascular smooth muscle in the hamster cheek pouch." Microcirculation (New York, N.Y. : 1994). 2001; 8(6):403-13. |
| Molkentin JD; Antos C; Mercer B; Taigen T; Miano JM; Olson EN. "Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart." Developmental biology. 2000; 217(2):301-9. |
| Nobrega MA; Shiozawa M; Koike G; Jacob HJ; Miano JM. "Gene structure and chromosomal mapping of the rat smooth muscle calponin gene." Mammalian genome : official journal of the International Mammalian Genome Society. 2000; 11(2):115-9. |
| Miano JM; Carlson MJ; Spencer JA; Misra RP. "Serum response factor-dependent regulation of the smooth muscle calponin gene." The Journal of biological chemistry. 2000; 275(13):9814-22. |
| Camoretti-Mercado B; Liu HW; Halayko AJ; Forsythe SM; Kyle JW; Li B; Fu Y; McConville J; Kogut P; Vieira JE; Patel NM; Hershenson MB; Fuchs E; Sinha S; Miano JM; Parmacek MS; Burkhardt JK; Solway J. "Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor." The Journal of biological chemistry. 2000; 275(39):30387-93. |
| Miano JM; Berk BC. "Retinoids: versatile biological response modifiers of vascular smooth muscle phenotype." Circulation research. 2000; 87(5):355-62. |
| Ou H; Haendeler J; Aebly MR; Kelly LA; Cholewa BC; Koike G; Kwitek-Black A; Jacob HJ; Berk BC; Miano JM. "Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells." Circulation research. 2000; 87(10):881-7. |
| Kowal RC; Richardson JA; Miano JM; Olson EN. "EVEC, a novel epidermal growth factor-like repeat-containing protein upregulated in embryonic and diseased adult vasculature." Circulation research. 1999; 84(10):1166-76. |
| Koike G; Miano JM; Vanvooren P; Shiozawa M; Szpirer C; Jacob HJ. "Mapping of the rat SM22 gene to chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy." Mammalian genome : official journal of the International Mammalian Genome Society. 1998; 9(1):76-7. |
| Zilberman A; Dave V; Miano J; Olson EN; Periasamy M. "Evolutionarily conserved promoter region containing CArG*-like elements is crucial for smooth muscle myosin heavy chain gene expression." Circulation research. 1998; 82(5):566-75. |
| Firulli AB; Han D; Kelly-Roloff L; Koteliansky VE; Schwartz SM; Olson EN; Miano JM. "A comparative molecular analysis of four rat smooth muscle cell lines." In vitro cellular & developmental biology. Animal. 1998; 34(3):217-26. |
| Miano JM; Kelly LA; Artacho CA; Nuckolls TA; Piantedosi R; Blaner WS. "all-Trans-retinoic acid reduces neointimal formation and promotes favorable geometric remodeling of the rat carotid artery after balloon withdrawal injury." Circulation. 1998; 98(12):1219-27. |
| Miano JM; Krahe R; Garcia E; Elliott JM; Olson EN. "Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene." Gene. 1997; 197(1-2):215-24. |
| Rao RS; Miano JM; Olson EN; Seidel CL. "The A10 cell line: a model for neonatal, neointimal, or differentiated vascular smooth muscle cells?" Cardiovascular research. 1997; 36(1):118-26. |
| Miano, J.M.; Firulli, A.B.; Olson, E.N.; Hara, P.; Giachelli, C.M.; Schwartz, S.M. "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells." Proceedings of the National Academy of Sciences, USA 93 (1996): 900-905. |
| Li L; Miano JM; Cserjesi P; Olson EN. "SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis." Circulation research. 1996; 78(2):188-95. |
| Firulli AB; Miano JM; Bi W; Johnson AD; Casscells W; Olson EN; Schwarz JJ. "Myocyte enhancer binding factor-2 expression and activity in vascular smooth muscle cells. Association with the activated phenotype." Circulation research. 1996; 78(2):196-204. |
| Li L; Miano JM; Mercer B; Olson EN. "Expression of the SM22alpha promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells." The Journal of cell biology. 1996; 132(5):849-59. |
| Miano JM; Topouzis S; Majesky MW; Olson EN. "Retinoid receptor expression and all-trans retinoic acid-mediated growth inhibition in vascular smooth muscle cells." Circulation. 1996; 93(10):1886-95. |
| Miano JM; Olson EN. "Expression of the smooth muscle cell calponin gene marks the early cardiac and smooth muscle cell lineages during mouse embryogenesis." The Journal of biological chemistry. 1996; 271(12):7095-103. |
| Martin, J.F.; Miano, J.M.; Hustad, C.M.; Copeland, N.G.; Jenkins, N.A.; Olson, E.N. "A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing." Molecular & Cellular Biology 14 (1994): 1647-1656. |
| Miano JM; Cserjesi P; Ligon KL; Periasamy M; Olson EN. "Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis." Circulation research. 1994; 75(5):803-12. |
| Pritchard KA; O'Banion MK; Miano JM; Vlasic N; Bhatia UG; Young DA; Stemerman MB. "Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo." The Journal of biological chemistry. 1994; 269(11):8504-9. |
| Miano, J.M.; Vlasic, N.; Tota, R.R.; Stemerman, M.B. "Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury: A putative in vivo mechanism for autocrine growth." Arteriosclerosis & Thrombosis 13 (1993): 211-219. |
| Miano JM; Vlasic N; Tota RR; Stemerman MB. "Localization of Fos and Jun proteins in rat aortic smooth muscle cells after vascular injury." The American journal of pathology. 1993; 142(3):715-24. |
| Miano JM; Tota RR; Vlasic N; Danishefsky KJ; Stemerman MB. "Early proto-oncogene expression in rat aortic smooth muscle cells following endothelial removal." The American journal of pathology. 1990; 137(4):761-5. |
