Lianping Xing, M.D., Ph.D.

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The major focus of my research is to study the regulation of bone cell function in inflammatory bone loss using combinations of genetically modified animals, in vivo imaging technologies, histology and in vitro cellular and molecular approaches. I have two established research programs which are funded by NIH to investigate the molecular mechanisms mediating increased osteoclastic bone resorption and reduced osteoblastic bone formation in animal models of rheumatoid arthritis (RA). Patients with RA suffer from joint inflammation and bone erosion as well as systemic osteoporosis. In one program, we are investigating the mechanism by which pro-inflammatory cytokine TNF affects joint tissue injury in RA through the regulation of function of osteoclasts and precursors. In another program, we are investigating the role of ubiquitin-mediated proteasomal degradation in osteoblast function in RA. Currently, we are testing the hypothesis that an inflammatory bone marrow environment increases proteasome-mediated protein degradation in mesenchymal stem cells and inhibits their differentiation to osteoblast precursors, accounting for inflammation-mediated bone loss. The ultimate goal of our research is to provide pre-clinical information that is useful for developing agents that improve bone health in patients with chronic inflammatory disorders.

Current Appointments

• Associate Professor - Department of Pathology and Laboratory Medicine (SMD)

Education
PhD Physiology, All Other	Penn State Univ Coll Medicine	1994
MS Medicine	China - Free-Standing Inst	1985
MD Medicine	China - Free-Standing Inst	1977

Recent Journal Articles
Showing the 5 most recent journal articles. (68 available)
Guo R; Zhou Q; Proulx ST; Wood R; Ji RC; Ritchlin CT; Pytowski B; Zhu Z; Wang YJ; Schwarz EM; Xing L. "Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis." Arthritis and rheumatism. 2009; 60(9):2666-2676. Epub 2009 Aug 27.
Jonason JH; Xiao G; Zhang M; Xing L; Chen D. "Post-translational Regulation of Runx2 in Bone and Cartilage." Journal of dental research. 2009; 88(8):693-703.
Zhang M; Yan Y; Lim YB; Tang D; Xie R; Chen A; Tai P; Harris SE; Xing L; Qin YX; Chen D. "BMP-2 modulates beta-catenin signaling through stimulation of Lrp5 expression and inhibition of beta-TrCP expression in osteoblasts." Journal of cellular biochemistry. 2009; Epub 2009 Sep 30.
Usui M; Xing L; Drissi H; Zuscik M; O'Keefe R; Chen D; Boyce BF. "Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2008; 23(3):314-25.
Yao Z; Xing L; Qin C; Schwarz EM; Boyce BF. "Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism." The Journal of biological chemistry. 2008; 283(15):9917-24. Epub 2008 Feb 04.