Lin Gan, Ph.D.
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Current Appointments
- Dean's Professorship - Department of Dean's Office, SMD (SMD)
- Professor - Department of Ophthalmology (SMD)
- Professor - Department of Center for Visual Science (RC)
- Professor - Department of Neurobiology and Anatomy (SMD)
| Journal Articles |
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| Showing 47 journal articles currently available. |
| Ding, Q., Chen, H., Xie, X., Libby, R., Tian, N., and Gan, L. "BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons." Journal of Neuroscience 29(13) (2009): 3992– 4003 (Cover Photograph). |
| Sakagami K; Gan L; Yang XJ. "Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(21):6932-44. |
| Pan L; Deng M; Xie X; Gan L. "ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells". Development (Cambridge, England) 135 (2008): 1981-90 (Cover Photograph). |
| Elshatory Y; Gan L. "The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008; 28(13):3291-7. |
| Joshi PS; Molyneaux BJ; Feng L; Xie X; Macklis JD; Gan L. "Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex." Neuron. 2008; 60(2):258-72. |
| Elshatory Y; Everhart D; Deng M; Xie X; Barlow RB; Gan L. "Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells". The Journal of neuroscience : the official journal of the Society for Neuroscience 27 (2007): 12707-20. |
| Shibasaki K; Takebayashi H; Ikenaka K; Feng L; Gan L. "Expression of the basic helix-loop-factor Olig2 in the developing retina: Olig2 as a new marker for retinal progenitors and late-born cells." Gene expression patterns : GEP. 2007; 7(1-2):57-65. Epub 2006 May 26. |
| Elshatory Y; Deng M; Xie X; Gan L. "Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina." The Journal of comparative neurology. 2007; 503(1):182-97. |
| Feng L; Xie X; Joshi PS; Yang Z; Shibasaki K; Chow RL; Gan L. "Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina". Development (Cambridge, England) 133 (2006): 4815-25. Epub 2006 Nov 08. (Cover Photograph). |
| Deng M; Pan L; Xie X; Gan L. "Differential expression of LIM domain-only (LMO) genes in the developing mouse inner ear." Gene expression patterns : GEP. 2006; 6(8):857-63. Epub 2006 Apr 04. |
| Pan L; Yang Z; Feng L; Gan L. "Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis". Development (Cambridge, England) 132(4) (2005): 703-12. Epub 2005 Jan 12. (Cover Photograph). |
| Xie J; Lü L; Deng M; Weng S; Zhu J; Wu Y; Gan L; Chan SM; He J. "Inhibition of reporter gene and Iridovirus-tiger frog virus in fish cell by RNA interference." Virology. 2005; 338(1):43-52. |
| Yan DH; Wen Y; Su LK; Xia W; Wang SC; Zhang S; Gan L; Lee DF; Spohn B; Frey JA; Hortobagyi GN; Hung MC. "A delayed chemically induced tumorigenesis in Brca2 mutant mice." Oncogene. 2004; 23(10):1896-901. |
| Radde-Gallwitz K; Pan L; Gan L; Lin X; Segil N; Chen P. "Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear." The Journal of comparative neurology. 2004; 477(4):412-21. |
| Yang Z; Ding K; Pan L; Deng M; Gan L. "Math5 determines the competence state of retinal ganglion cell progenitors." Developmental biology. 2003; 264(1):240-54. |
| Wang SW; Mu X; Bowers WJ; Kim DS; Plas DJ; Crair MC; Federoff HJ; Gan L; Klein WH. "Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth." Development (Cambridge, England). 2002; 129(2):467-77. |
| Guo Z; Clydesdale G; Cheng J; Kim K; Gan L; McConkey DJ; Ullrich SE; Zhuang Y; Su B. "Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction." Molecular and cellular biology. 2002; 22(16):5761-8. |
| Yeh S; Tsai MY; Xu Q; Mu XM; Lardy H; Huang KE; Lin H; Yeh SD; Altuwaijri S; Zhou X; Xing L; Boyce BF; Hung MC; Zhang S; Gan L; Chang C; Hung MC. "Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues." Proceedings of the National Academy of Sciences of the United States of America. 2002; 99(21):13498-503. Epub 2002 Oct 07. |
| Wee R; Castrucci AM; Provencio I; Gan L; Van Gelder RN. "Loss of photic entrainment and altered free-running circadian rhythms in math5-/- mice." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002; 22(23):10427-33. |
| Lu JR; Bassel-Duby R; Hawkins A; Chang P; Valdez R; Wu H; Gan L; Shelton JM; Richardson JA; Olson EN. "Control of facial muscle development by MyoR and capsulin." Science (New York, N.Y.). 2002; 298(5602):2378-81. |
| Wang SW; Kim BS; Ding K; Wang H; Sun D; Johnson RL; Klein WH; Gan L. "Requirement for math5 in the development of retinal ganglion cells." Genes & development. 2001; 15(1):24-9. |
| Eng SR; Gratwick K; Rhee JM; Fedtsova N; Gan L; Turner EE. "Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001; 21(2):541-9. |
| Kim BS; Savinova OV; Reedy MV; Martin J; Lun Y; Gan L; Smith RS; Tomarev SI; John SW; Johnson RL. "Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function." Molecular and cellular biology. 2001; 21(22):7707-13. |
| Mu X; Zhao S; Pershad R; Hsieh TF; Scarpa A; Wang SW; White RA; Beremand PD; Thomas TL; Gan L; Klein WH. "Gene expression in the developing mouse retina by EST sequencing and microarray analysis." Nucleic acids research. 2001; 29(24):4983-93. |
| Wang SW; Gan L; Martin SE; Klein WH. "Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU-domain transcription factor Brn-3b". Molecular and Cellular Neurosciences 16(2) (2000): 141-56. (Cover Photograph). |
| Lu J; Chang P; Richardson JA; Gan L; Weiler H; Olson EN. "The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis." Proceedings of the National Academy of Sciences of the United States of America. 2000; 97(17):9525-30. |
| Vivian JL; Gan L; Olson EN; Klein WH. "A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation." Developmental biology. 1999; 208(1):44-55. |
| Gan L; Wang SW; Huang Z; Klein WH. "POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification." Developmental biology. 1999; 210(2):469-80. |
| Wagner DS; Gan L; Klein WH. "Identification of a differentially expressed RNA helicase by gene trapping." Biochemical and biophysical research communications. 1999; 262(3):677-84. |
| Chen H; Lun Y; Ovchinnikov D; Kokubo H; Oberg KC; Pepicelli CV; Gan L; Lee B; Johnson RL. "Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome." Nature genetics. 1998; 19(1):51-5. |
| Evrard YA; Lun Y; Aulehla A; Gan L; Johnson RL. "lunatic fringe is an essential mediator of somite segmentation and patterning." Nature. 1998; 394(6691):377-81. |
| Lin X; Gan L; Klein WH; Wells D. "Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene." Biochemical and biophysical research communications. 1998; 248(3):738-43. |
| Wagner DS; Gan L; Klein WH. "Expression of a gene trap reporter construct in a subset of cells in embryonic sites of hematopoiesis: evidence for alternative rRNA production in hematopoietic cells." Biochemical and biophysical research communications. 1998; 250(3):674-81. |
| Klein, W.H., Mao, C-A., Gan, L., Chuang, C-K., and Wikramanayake, A.H. "Manipulating cell fates in the sea urchin embryo". Invertebrate Reproduction and Development 31 (1997): 21-29. |
| Xiang M; Gan L; Li D; Chen ZY; Zhou L; O'Malley BW; Klein W; Nathans J. "Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development." Proceedings of the National Academy of Sciences of the United States of America. 1997; 94(17):9445-50. |
| Xiang M; Gan L; Li D; Zhou L; Chen ZY; Wagner D; O'Malley BW; Klein W; Nathans J. "Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems." Cold Spring Harbor symposia on quantitative biology. 1997; 62():325-36. |
| Mao CA; Wikramanayake AH; Gan L; Chuang CK; Summers RG; Klein WH. "Altering cell fates in sea urchin embryos by overexpressing SpOtx, an orthodenticle-related protein." Development (Cambridge, England). 1996; 122(5):1489-98. |
| Gan L; Xiang M; Zhou L; Wagner DS; Klein WH; Nathans J. "POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells." Proceedings of the National Academy of Sciences of the United States of America. 1996; 93(9):3920-5. |
| Xiang M; Gan L; Zhou L; Klein WH; Nathans J. "Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling." Proceedings of the National Academy of Sciences of the United States of America. 1996; 93(21):11950-5. |
| Gan L; Mao CA; Wikramanayake A; Angerer LM; Angerer RC; Klein WH. "An orthodenticle-related protein from Strongylocentrotus purpuratus." Developmental biology. 1995; 167(2):517-28. |
| Mao CA; Gan L; Klein WH. "Multiple Otx binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene." Developmental biology. 1994; 165(1):229-42. |
| Gan L; Klein WH. "A positive cis-regulatory element with a bicoid target site lies within the sea urchin Spec2a enhancer." Developmental biology. 1993; 157(1):119-32. |
| Venuti JM; Gan L; Kozlowski MT; Klein WH. "Developmental potential of muscle cell progenitors and the myogenic factor SUM-1 in the sea urchin embryo." Mechanisms of development. 1993; 41(1):3-14. |
| Kozlowski MT; Gan L; Venuti JM; Sawadogo M; Klein WH. "Sea urchin USF: a helix-loop-helix protein active in embryonic ectoderm cells." Developmental biology. 1991; 148(2):625-30. |
| Klein, W.H., Tomlinson, C.R., Zhang, W., Xiang, M., Kozlowski, M.T., Gan, L., Nguyen, T., and Wessel, G.M. "Ectoderm differentiation and the Spec gene family of sea urchin. In Developmental biology". UCLA Symposium on Molecular and Cellular Biology, New Series 125 (1990): 123-134. |
| Gan L; Zhang W; Klein WH. "Repetitive DNA sequences linked to the sea urchin spec genes contain transcriptional enhancer-like elements". Developmental Biology 139(1) (1990): 186-96. (Cover Photograph). |
| Gan L; Wessel GM; Klein WH. "Regulatory elements from the related spec genes of Strongylocentrotus purpuratus yield different spatial patterns with a lacZ reporter gene." Developmental biology. 1990; 142(2):346-59. |
