Jane Sottile, Ph.D.

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Research Overview

A precise balance between the deposition and degradation of extracellular matrix molecules, including collagen type I and fibronectin, is required for normal tissue function, and is a key component of normal tissue repair. The studies in my lab are focused on understanding the mechanisms that control extracellular matrix remodeling. Our data show that the extracellular matrix protein, fibronectin, plays a key role in controlling the deposition and stability of extracellular matrix proteins, including collagen I. Our data also demonstrate that the polymerization of fibronectin into the extracellular matrix regulates adhesion-dependent cell growth, cell contractility and cell migration. Agents that disrupt fibronectin polymerization trigger enhanced fibronectin and collagen I turnover; these agents also induce turnover of fibronectin in tissues. These data indicate that extracellular matrix turnover is regulated by fibronectin polymerization. Hence, agents that regulate fibronectin polymerization are likely to be crucial in controlling cell proliferation, migration, and extracellular matrix remodeling, all of which are key events that occur during vascular remodeling, wound healing, and fibrosis. We are currently studying the mechanisms by which fibronectin polymerization regulates extracellular matrix remodeling, cell growth, and cell migration using in vitro, ex vivo and in vivo approaches. These studies will provide important insights into factors that contribute to the development of fibrosis, and into mechanisms that could prevent the progression of fibrosis. These studies will also provide important insights into the complex interplay between smooth muscle cells and extracellular matrix, which plays a critical role in the development and progression of vascular disease.

Current Appointments

• Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD)

Lab Website

http://www.urmc.rochester.edu/cvri/research/sottile-lab.cfm