Xinping Zhang, M.D., Ph.D.

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Contact

University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, New York 14642

Office: 585 275-7928

Lab: 585 273-4255

Portrait

Adult mesenchymal stem cells (MSCs) have enormous potential for bone tissue repair and regeneration. Our research has been focused on understanding the molecular and cellular mechanisms that control the activation, proliferation and differentiation of mesenchymal stem cells during skeletal repair. We are particularly interested in the periosteal stem cells that play key roles in repair and regeneration. Our current program has integrated the following topics:

1) Molecular signals that control mesenchymal stem cell differentiation.

2) Mechanism of skeletal repair and regeneration

3) Stem cell therapy and bone tissue engineering for repair and reconstruction of large segmental defects.

Current Appointments

Education
PhD, Biochemistry University of Rochester School of Medicine & Dentistry 1999
MS, Biochemistry China-Shanghai Medical University 1993
MD Medicine China-Shanghai Medical University 1990

Lab Description

The Center for Musculoskeletal Research houses nearly 70 MD and PhD researchers and graduate and post-doctoral students. This team has been the top orthopaedics lab in the United States since 2006.

Lab Website

http://www.urmc.rochester.edu/ortho/research/index.cfm

Recent Journal Articles
Showing the 5 most recent journal articles. (46 available)
Naik A; Xie, C; Kingsley, P; Zuscik, MJ; Schwarz, EM; Awad, H; Guldberg, R; Drissi, H; Puzas, E; Boyce, B; Zhang, X; O'Keefe, RJ. "Reduced COX-2 expression in aged mice is associated with impaired fracture healing". Journal of Bone & Mineral Research 24(2) (2009): 251-64.
Xie, C; Liang, B; Xue, M; Lin, ASP; Loiselle, A; Schwarz, EM; Guldberg, RE; O'Keefe, RJ; Zhang, X. "Rescue of Impaired Fracture Healing in Cox-2-/- mice via Activation of Prostaglandin E2 Receptor Subtype 4". The American Journal of Pathology 175(2) (2009): 772-85.
Clark, CA; Li, TF; Kim, KO; Drissi, H; Zuscik, MJ; Zhang, X; O'Keefe, RJ. "Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation". J. Orthop. Res. 27(6) (2009): 785-92.
Tsutsumi, R; Xie, C; Wei, X; Zhang, X; Flick, LM; Schwarz, EM; O'Keefe, RJ. "PGE2 Signaling Through the EP4 Receptor on Fibroblasts Upregulates RANKL and Stimulates Osteolysis". J Bone Miner Res 24(10) (2009): 1753-62.
Zhang, X., Awad, A.H., O'Keefe, R.J., Guldberg, R.J., Schwarz, E.M. "Periosteum is essential for the initiation of structural bone graft healing: implication for tissue engineering." Clinical Orthopaedics and Related Research. (2008).