Andrea J. Sant, Ph.D.
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Current Appointments
- Professor - Department of Microbiology and Immunology, Center for Vaccine Biology and Immunology (SMD)
| Journal Articles |
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| Showing 55 journal articles currently available. |
| Bandyopadhyay A; Arneson L; Beeson C; Sant AJ. "The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM function." Molecular immunology. 2008; 45(5):1248-57. Epub 2007 Nov 05. |
| Menges PR; Jenks SA; Bikoff EK; Friedmann DR; Knowlden ZA; Sant AJ. "An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice." Journal of immunology (Baltimore, Md. : 1950). 2008; 180(3):1619-33. |
| Larkin J; Rankin AL; Picca CC; Riley MP; Jenks SA; Sant AJ; Caton AJ. "CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen." Journal of immunology (Baltimore, Md. : 1950). 2008; 180(4):2149-57. |
| Huang S; Gilfillan S; Kim S; Thompson B; Wang X; Sant AJ; Fremont DH; Lantz O; Hansen TH. "MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells." The Journal of experimental medicine. 2008; 205(5):1201-11. Epub 2008 Apr 28. |
| Weaver JM; Lazarski CA; Richards KA; Chaves FA; Jenks SA; Menges PR; Sant AJ. "Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design." Journal of immunology (Baltimore, Md. : 1950). 2008; 181(5):3039-48. |
| Gardiner A; Richards KA; Sant AJ; Arneson LS. "Conformation of MHC class II I-A(g7) is sensitive to the P9 anchor amino acid in bound peptide." International immunology. 2007; 19(9):1103-13. |
| Chaves FA; Sant AJ. "Measurement of peptide dissociation from MHC class II molecules." Current protocols in immunology / edited by John E. Coligan ... [et al.]. 2007; Chapter 18():Unit 18.14. |
| Lazarski CA; Chaves FA; Sant AJ. "The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability." The Journal of experimental medicine. 2006; 203(5):1319-28. Epub 2006 May 08. |
| Chaves FA; Richards KA; Torelli A; Wedekind J; Sant AJ. "Peptide-binding motifs for the I-Ad MHC class II molecule: alternate pH-dependent binding behavior." Biochemistry. 2006; 45(20):6426-33. |
| Chaves FA; Hou P; Wu S; Sant AJ. "Replacement of the membrane proximal region of I-A(d) MHC class II molecule with I-E-derived sequences promotes production of an active and stable soluble heterodimer without altering peptide-binding specificity." Journal of immunological methods. 2005; 300(1-2):74-92. |
| McFarland BJ; Katz JF; Sant AJ; Beeson C. "Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein." Journal of molecular biology. 2005; 350(1):170-83. |
| Lazarski CA; Chaves FA; Jenks SA; Wu S; Richards KA; Weaver JM; Sant AJ. "The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance." Immunity. 2005; 23(1):29-40. |
| Sant AJ; Chaves FA; Jenks SA; Richards KA; Menges P; Weaver JM; Lazarski CA. "The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes." Immunological reviews. 2005; 207():261-78. |
| McFarland BJ; Katz JF; Beeson C; Sant AJ. "Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes." Proceedings of the National Academy of Sciences of the United States of America. 2001; 98(16):9231-6. Epub 2001 Jul 24. |
| Arneson LS; Katz JF; Liu M; Sant AJ. "Hydrogen bond integrity between MHC class II molecules and bound peptide determines the intracellular fate of MHC class II molecules." Journal of immunology (Baltimore, Md. : 1950). 2001; 167(12):6939-46. |
| Arneson LS; Peterson M; Sant AJ. "The MHC class II molecule I-Ag7 exists in alternate conformations that are peptide dependent." Journal of immunology (Baltimore, Md. : 1950). 2000; 165(4):2059-67. |
| Nanda NK; Sant AJ. "DM determines the cryptic and immunodominant fate of T cell epitopes." The Journal of experimental medicine. 2000; 192(6):781-8. |
| Siemasko K; Eisfelder BJ; Stebbins C; Kabak S; Sant AJ; Song W; Clark MR. "Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation." Journal of immunology (Baltimore, Md. : 1950). 1999; 162(11):6518-25. |
| McFarland BJ; Beeson C; Sant AJ. "Cutting edge: a single, essential hydrogen bond controls the stability of peptide-MHC class II complexes." Journal of immunology (Baltimore, Md. : 1950). 1999; 163(7):3567-71. |
| Bryant PW; Roos P; Ploegh HL; Sant AJ. "Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties." European journal of immunology. 1999; 29(9):2729-39. |
| McFarland BJ; Sant AJ; Lybrand TP; Beeson C. "Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers." Biochemistry. 1999; 38(50):16663-70. |
| Sant AJ; Beeson C; McFarland B; Cao J; Ceman S; Bryant PW; Wu S. "Individual hydrogen bonds play a critical role in MHC class II: peptide interactions: implications for the dynamic aspects of class II trafficking and DM-mediated peptide exchange." Immunological reviews. 1999; 172():239-53. |
| Peterson M; Sant AJ. "The inability of the nonobese diabetic class II molecule to form stable peptide complexes does not reflect a failure to interact productively with DM." Journal of immunology (Baltimore, Md. : 1950). 1998; 161(6):2961-7. |
| Ceman S; Wu S; Jardetzky TS; Sant AJ. "Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class II molecules after invariant chain removal." The Journal of experimental medicine. 1998; 188(11):2139-49. |
| Tan LJ; Ceman S; Chervonsky A; Rodriguez-Paris J; Steck TL; Sant AJ. "Late events in the intracellular sorting of major histocompatibility complex class II molecules are regulated by the 80-82 segment of the class II beta chain." European journal of immunology. 1997; 27(6):1479-88. |
| Katz JF; Stebbins C; Appella E; Sant AJ. "Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules." The Journal of experimental medicine. 1996; 184(5):1747-53. |
| Stebbins CC; Peterson ME; Suh WM; Sant AJ. "DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules." Journal of immunology (Baltimore, Md. : 1950). 1996; 157(11):4892-8. |
| Ceman, S. and Sant, A.J.. "The function of invariant chain in class II-restricted antigen presentation." Sem. Immunol. Sem. Immunol. 7 (1995): 373-387. |
| Zuckerman LA; Sant AJ; Miller J. "Identification of a unique costimulatory activity for murine T helper 1 T cell clones." Journal of immunology (Baltimore, Md. : 1950). 1995; 154(9):4503-12. |
| Chervonsky A; Sant AJ. "In the absence of major histocompatibility complex class II molecules, invariant chain is translocated to late endocytic compartments by autophagy." European journal of immunology. 1995; 25(4):911-8. |
| Stebbins CC; Loss GE; Elias CG; Chervonsky A; Sant AJ. "The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent." The Journal of experimental medicine. 1995; 181(1):223-34. |
| Ceman S; Sant AJ. "The function of invariant chain in class II-restricted antigen presentation." Seminars in immunology. 1995; 7(6):373-87. |
| Sant, A. J. "Endogenous antigen presentation by MHC class II molecule." Immunologic Research 13 (1994): 253-267. |
| Sant, A. J.; J. Miller. "MHC class II antigen processing:biology of invariant chain." Current Opinion in Immunol. 6 (1994): 57-63. |
| Sant AJ. "Endogenous antigen presentation by MHC class II molecules." Immunologic research. 1994; 13(4):253-67. |
| Katz JF; Sant AJ. "T cell receptor recognition of MHC class II alloantigens is highly cell type dependent." Journal of immunology (Baltimore, Md. : 1950). 1994; 152(4):1629-40. |
| Chervonsky AV; Gordon L; Sant AJ. "A segment of the MHC class II beta chain plays a critical role in targeting class II molecules to the endocytic pathway." International immunology. 1994; 6(7):973-82. |
| Sant AJ; Miller J. "MHC class II antigen processing: biology of invariant chain." Current opinion in immunology. 1994; 6(1):57-63. |
| Sant AJ. "Isotypic residues in the membrane proximal domain of MHC class II beta-chains control activation of CD4+ T cells." Journal of immunology (Baltimore, Md. : 1950). 1993; 150(12):5299-310. |
| Loss GE; Elias CG; Fields PE; Ribaudo RK; McKisic M; Sant AJ. "Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways." The Journal of experimental medicine. 1993; 178(1):73-85. |
| Loss GE; Sant AJ. "Invariant chain retains MHC class II molecules in the endocytic pathway." Journal of immunology (Baltimore, Md. : 1950). 1993; 150(8 Pt 1):3187-97. |
| McKisic MD; Sant AJ; Fitch FW. "Some cloned murine CD4+ T cells recognize H-2Ld class I MHC determinants directly. Other cloned CD4+ T cells recognize H-2Ld class I MHC determinants in the context of class II MHC molecules." Journal of immunology (Baltimore, Md. : 1950). 1991; 147(9):2868-74. |
| Sant AJ; Hendrix LR; Coligan JE; Maloy WL; Germain RN. "Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains." The Journal of experimental medicine. 1991; 174(4):799-808. |
| Lechler RI; Sant AJ; Braunstein NS; Sekaly R; Long E; Germain RN. "Cell surface expression of hybrid murine/human MHC class II beta alpha dimers. Key influence of residues in the amino-terminal portion of the beta 1 domain." Journal of immunology (Baltimore, Md. : 1950). 1990; 144(1):329-33. |
| Sant AJ; Germain RN. "Intracellular competition for component chains determines class II MHC cell surface phenotype." Cell. 1989; 57(5):797-805. |
| Germain, R.N.; Sant, A.J.; Braunstein, N.S.; Ronchese, F. ""The molecular basis of antigen presentation"." Princess Takamatsu Symp 19 (1988): 179-191. |
| Sant AJ; Zacheis M; Rumbarger T; Giacoletto KS; Schwartz BD. "Human Ia alpha- and beta-chains are sulfated." Journal of immunology (Baltimore, Md. : 1950). 1988; 140(1):155-60. |
| Germain RN; Sant AJ; Braunstein NS; Ronchese F. "The molecular basis of antigen presentation." Princess Takamatsu symposia. 1988; 19():179-91. |
| Sant AJ; Braunstein NS; Germain RN. "Predominant role of amino-terminal sequences in dictating efficiency of class II major histocompatibility complex alpha beta dimer expression." Proceedings of the National Academy of Sciences of the United States of America. 1987; 84(22):8065-9. |
| Giacoletto KS; Sant AJ; Bono C; Gorka J; O'Sullivan DM; Quaranta V; Schwartz BD. "The human invariant chain is the core protein of the human class II-associated proteoglycan." The Journal of experimental medicine. 1986; 164(5):1422-39. |
| Sant AJ; Cullen SE; Schwartz BD. "Biosynthetic relationships of the chondroitin sulfate proteoglycan with Ia and invariant chain glycoproteins." Journal of immunology (Baltimore, Md. : 1950). 1985; 135(1):416-22. |
| Sant AJ; Cullen SE; Giacoletto KS; Schwartz BD. "Invariant chain is the core protein of the Ia-associated chondroitin sulfate proteoglycan." The Journal of experimental medicine. 1985; 162(6):1916-34. |
| Sant AJ; Schwartz BD; Cullen SE. "Cellular distribution of the Ia-associated chondroitin sulfate proteoglycan." Journal of immunology (Baltimore, Md. : 1950). 1985; 135(1):408-15. |
| Sant AJ; Cullen SE; Schwartz BD. "Identification of a sulfate-bearing molecule associated with HLA class II antigens." Proceedings of the National Academy of Sciences of the United States of America. 1984; 81(5):1534-8. |
| Sant AJ; Schwartz BD; Cullen SE. "Identification of a new component in the murine Ia molecular complex." The Journal of experimental medicine. 1983; 158(6):1979-92. |
