Rashid Deane, B.Sc., Ph.D.

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Research interest includes the following:

1) Control of the brain microenvironment (Blood-brain barrier, choroid plexus and cerebrospinal fluid).

2) Metals in health and disease.

3) Aging and neurodegenerative diseases (e.g. Alzheimer's disease).

Current Appointments

• Research Professor - Department of Neurosurgery, Center for Neurodegenerative & Vascular Brain Disorders (SMD)

Education
PhD Medical Physiology	St. Thomas's Hospital Medical School	1983
BSc Physiology	Bedford College, University of London	1974

Post-Doctoral Training & Residency
Postdoctoral Research Fellow, King's College London, England	1984 - 1987
Postdoctoral Research Associate; University of Hull; Hull, UK	1982 - 1983

Lab Description

Research interest. 1) Blood-brain barrier/ choroid plexus/ CSF. 2) Metals in health and disease. 3) Aging and neurodegenerative diseases ( Alzheimer's disease)

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Recent Journal Articles
Showing the 5 most recent journal articles. (35 available)
Deane R; LaRue B; Sagare AP; Castellino FJ; Zhong Z; Zlokovic BV. "Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2009; 29(1):25-33. Epub 2008 Oct 08.
Bell RD; Deane R; Chow N; Long X; Sagare A; Singh I; Streb JW; Guo H; Rubio A; Van Nostrand W; Miano JM; Zlokovic BV. "SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells." Nature cell biology. 2009; 11(2):143-53. Epub 2008 Dec 21.
Guo H; Singh I; Wang Y; Deane R; Barrett T; Fernández JA; Chow N; Griffin JH; Zlokovic BV. "Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity." The European journal of neuroscience. 2009; 29(6):1119-30.
Zhong Z; Deane R; Ali Z; Parisi M; Shapovalov Y; O'Banion MK; Stojanovic K; Sagare A; Boillee S; Cleveland DW; Zlokovic BV. "ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration." Nature neuroscience. 2008; 11(4):420-2. Epub 2008 Mar 16.
Deane R; Sagare A; Hamm K; Parisi M; Lane S; Finn MB; Holtzman DM; Zlokovic BV. "apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain." The Journal of clinical investigation. 2008; Epub 2008 Nov 13.