Arshad Rahman, Ph.D.

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Dr. Rahman's research interests are:

1) Signaling Mechanisms of Endothelial ICAM-1 Expression

2) Neutrophil-mediated Lung Injury.

They want to know how pro-inflammatory mediators such as thrombin and tumor necrosis factor alpha (TNF) mediate neutrophils (PMN) sequestration and emigration in the lung and thus induce lung vascular injury. In particular, they are interested in defining the critical signaling pathways mediating expression of intercellular adhesion molecule (CAM-1; CD54), an inducible endothelial adhesive protein that serves as a counter-receptor for ²2-integrins (CD11/CD18) present on the surface of leukocytes. Interaction of ICAM-1 with ²2-integrins enables PMN to adhere firmly and stably to the vascular endothelium, and to migrate across the endothelial barrier. PMN binding to endothelial cells by this mechanism contributes to the development of lung vascular injury and tissue edema.

Dr. Rahman uses multidisciplinary approaches ranging from cultured endothelial cells and in vivo mouse models with targeted gene deletions to molecular biology and lung physiology to address these questions of fundamental importance.

Specialty

Neonatology

Current Appointments

• Associate Professor - Department of Pediatrics (SMD)
• Associate Professor - Department of Environmental Medicine (SMD)