Bin Liu, M.D.
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Contact
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, ACVRI - 211 Bailey Road
Rochester, New York 14642
Lab: 585 276-9847
Fax: 585 276-9830
My research is focused on the regulation of mRNA stability of monocyte chemoattractant protein-1 (MCP-1) by PDGF and Angiotensin II (Ang II) in smooth muscle cells (SMC). MCP-1 promotes atherosclerosis and is a mediator of the response to arterial injury. MCP-1 level tracks its mRNA level under physiological or pathological conditions in animal models. MCP-1 mRNA is markedly elevated in response to PDGF-B or Ang II elevation largely due to increase of mRNA stability. Both PDGF-B and Ang II stabilize MCP-1 mRNA through a PKCd-dependent signaling pathway. Our ongoing research is to fully figure out the signaling pathways mediating the mRNA stabilizing effect, to isolate the MCP-1 mRNA stabilizing factor induced by PDGF-B and Ang II, and to reveal the RNases involved in PDGF-b and Ang II induced MCP-1 mRNA stabilization.
Current Appointments
- Research Assistant Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD)
| Education | ||
|---|---|---|
| MD Medicine | China-Bethune Med Univ, Changchun | 1982 |
| Post-Doctoral Training & Residency | |
|---|---|
| Senior Scientist Hamilton Thorne Biosciences, Inc., Beverly, MA | 2002 - 2003 |
| Research Fellow in Immunology Institute of Biological Products, Changchun, China | 1985 - 1987 |
| Junior Resident in Oral Surgery 4th Hospital of Bethune Medical School | 1984 - 1985 |
| Intern in Oral Surgery 4th Hospital of Bethune Medical School | 1983 - 1984 |
| Senior Resident in Oral Surgery 4th Hospital of Bethune Medical School | 1985 |
Lab Description
Regulation of MCP-1 mRNA stability
Lab Website
http://www.urmc.rochester.edu/cvri/research/taubman-lab.cfm
| Recent Journal Articles |
|---|
| Showing the 5 most recent journal articles. (9 available) |
| Dhawan L; Liu B; Blaxall BC; Taubman MB. "A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability." The Journal of biological chemistry. 2007; 282(14):10146-52. Epub 2007 Feb 02. |
| Liu, B.; Poon, M.; Taubman, MB. "PDGF-BB Enhances Monocyte chemoattractant protein-1 mRNA Stability in Smooth Muscle Cells by Downregulating ribonuclease Activity." Journal of Mol Cell Cardio 3 (2006): 426. |
| Liu B; Jiang S; Zhang W; Ye F; Wang YH; Wu J; Zhang DY. "Novel biodegradable HSAM nanoparticle for drug delivery." Oncology reports. 2006; 15(4):957-61. |
| Menzies K; Liu B; Kim WJ; Moschella MC; Taubman MB. "Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cells." Biochemical and biophysical research communications. 2004; 317(3):801-10. |
| Henderson C; Meyers B; Humayun Gultekin S; Liu B; Zhang DY. "Intracranial tuberculoma in a liver transplant patient: first reported case and review of the literature." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2003; 3(1):88-93. |
