Hulin Wu, Ph.D.

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My recent research interests include nonparametric regression methods and mixed-effects models for longitudinal data analysis, Bayesian and Monte Carlo filtering approaches for state-space models of biological systems, modeling HIV dynamics and AIDS clinical trials, pharmacokinetics and pharmacodynamics (PK/PD) modeling, and stochastic simulations and modeling of bioterrorist attacks. I am also expanding my research in the area of theoretical immunology.

I received my college education in engineering from the National University of Defense Technology, P.R. China (B.Sc., 1984; M.Sc., 1987). I earned my Ph.D. in statistics from Florida State University in 1994. After two years as a visiting Assistant Professor at the

University of Memphis (TN), I joined Frontier Science & Technology Research Foundation in 1996 as a Senior Statistician to work for Statistical Data Analysis Center (SDAC), currently Center for Biostatistics in AIDS Research (CBAR), Harvard School of Public Health, where I became involved in AIDS clinical trials and HIV dynamic modeling. I served as the Head of Pharmacology/Dynamic Modeling Section at SDAC, Adults AIDS Clinical Trials Group (AACTG) from 1999-2002. I also held an Adjunct Lecturership position at the Department of Biostatistics, Harvard University from 2000-2003. I joined the Department of Biostatistics and Computational Biology, University of Rochester as Professor in 2003.

Since 1998, I have been awarded four research grants to develop statistical methods and mathematical models for HIV dynamics and AIDS clinical trials by NIH. I have advised 9 postdoctoral research fellows from 1998-2005, and most of them obtained academic or research positions at major Universities or Research Institutes after completing their postdoctoral training. I am currently leading a group of faculty and postdoc fellows to work in several NIH-sponsored projects related to modeling of infectious diseases and immune response that include HIV/AIDS and influenza virus.

Recently I received a grant (contract) totaling $10 million over 5 years to establish a Center for Biodefense Immune Modeling (CBIM) where I serve as the Director. I also serve as Chief of the newly established Division of Biomedical Modeling and Informatics (DBMI) in the Department of Biostatistics and Computational Biology.

I received the First Prize Student Paper Award from the Statistics and the Environment Section, American Statistical Association in 1993; the ENAR Student Paper Award from the Eastern North American Region of the Biometrics Society (ENAR) in 1994; the Ralph A. Bradley Award from Department of Statistics, Florida State University in 1994; the Young Investigator Award from the Epidemiology Section, American Statistical Association in 1995; and the Young Scientist Scholarship Fund Award from the International Workshop on HIV Drug Resistance and Treatment Strategies in 1997 and 1998. I served as a grant review member for several AIDS and Related Research sections and special emphasis panels, National Institutes of Health (NIH). I also served as a consultant for other NIH grant review sections and the National Science Foundation (NSF).

Current Appointments

• Professor - Department of Biostatistics and Computational Biology (SMD)

Education
PhD Statistics	Florida State University	1994
MS Statistics	Florida State University	1991
BS Engineering	China - Non-Medical School	1984

Lab Website

http://www.urmc.rochester.edu/smd/biostat/people/faculty/WuSite/Index.htm

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Recent Journal Articles
Showing the 5 most recent journal articles. (50 available)
Huang, Y.; Wu, H. "A Bayesian Approach for Estimating Antiviral Efficacy in HIV Dynamic Models". Journal of Applied Statistics 33 (2006): 155-174.
Park, J.G.; Wu, H. "Backfitting and Local Likelihood Methods for Nonparametric Mixed-Effects Models with Longitudinal Data". JSPI (2006).
Huang, Y.; Liu, D.; Wu, H. "Hierarchical Bayesian Methods for Estimation of Parameters in a Longitudinal HIV Dynamic System". Biometrics (2006).
Liu, D.; Yu, J.; Reichman, R.; Chang, X.; Wu, H.; Jin, X. "Statistical Determination of Threshold for Cellular Division in the CFSE-Labeling Assay". Journal of Immunological Methods (2006).
Huang, Y.; Wu, H. "Bayesian Experimental Design for Long-Term Longitudinal HIV Dynamic Studies". JSPI (2006).